Triphenyl-sesquineolignan analogues derived from Illicium simonsii Maxim exhibit potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial membranes

[Display omitted] •Some triphenyl-sesquineolignan analogues from Illicium simonsii Maxim were prepared.•Compound 6 exhibited potent antibacterial activity against S. aureus and MRSA.•Compound 6 can kill bacteria more rapidly than tigecycline.•Compound 6 was unsusceptible to drug resistance developme...

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Veröffentlicht in:	Bioorganic chemistry 2021-05, Vol.110, p.104824-104824, Article 104824
Hauptverfasser:	Guo, Yong, Yang, Ruige, Chen, Fangfang, Yan, Tingting, Wen, Tingyu, Li, Fang, Su, Xiaoyu, Wang, Lei, Du, Juan, Liu, Jifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Antibacterial mechanism Illicium Methicillin-resistant Staphylococcus aureus Triphenyl-sesquineolignan
Online-Zugang:	Volltext
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