Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased r...
Gespeichert in:
| Veröffentlicht in: | Gut microbes 2021-01, Vol.13 (1), p.1-9 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Gut microbes |
| container_volume | 13 |
| creator | Mullish, Benjamin H. Marchesi, Julian R. McDonald, Julie A.K. Pass, Daniel A. Masetti, Giulia Michael, Daryn R. Plummer, Sue Jack, Alison A. Davies, Thomas S. Hughes, Timothy R. Wang, Duolao |
| description | Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m
2
experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people. |
| doi_str_mv | 10.1080/19490976.2021.1900997 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_2506281624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_5bb02bdabf9048ef9a01c33ef8db5747</doaj_id><sourcerecordid>2506281624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-807cb2c72a0e29798353612bb3bac95227e0edfdd48153598e9fa0cbce923c4d3</originalsourceid><addsrcrecordid>eNp9ks1uEzEUhUcIRKvSRwB5ySapx_aMbRb8qKJQqRIsYG35507iamY82J5EeSTeEqdJA93gja-Oj797ZZ-qel3jZY0Fvqolk1jydkkwqZe1xFhK_qw63-sLLAV7fqp5e1ZdpnSPy2KM45a-rM4o5S0TDT6vfn-PwfiQvU0ogpstoAR9t4gwhZjBobQbphyGhEKH5mmCWGxp8lHnEHcoR20z8mMHNvswlgqFDcQt-NU6Iz06FAwkQNrNfU7vUFqHuXdoC8gAsmFM3kH04wpNf8dw84OyKT16NBUGDEX-8Kp60ek-weVxv6h-3nz-cf11cffty-31p7uFbSjLC4G5NcRyojEQyaWgDW1rYgw12sqGEA4YXOccE3VDGylAdhpbY0ESapmjF9XtgeuCvldT9IOOOxW0Vw9CiCulYxm0B9UYg4lx2nQSMwGd1Li2lEInnGk444X1_sCaZjOAszCWB-ufQJ-ejH6tVmGjBMa8ZrQA3h4BMfyaIWU1-GSh7_UIYU6KNLglom4JK9bmYLUxpBShO7WpsdqnRj2mRu1To46pKffe_Dvj6dZjRorh48FQvjnEQW9D7J3KeteH2EU9Wp8U_X-PPxqM17o</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2506281624</pqid></control><display><type>article</type><title>Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?</title><source>Taylor & Francis Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Mullish, Benjamin H. ; Marchesi, Julian R. ; McDonald, Julie A.K. ; Pass, Daniel A. ; Masetti, Giulia ; Michael, Daryn R. ; Plummer, Sue ; Jack, Alison A. ; Davies, Thomas S. ; Hughes, Timothy R. ; Wang, Duolao</creator><creatorcontrib>Mullish, Benjamin H. ; Marchesi, Julian R. ; McDonald, Julie A.K. ; Pass, Daniel A. ; Masetti, Giulia ; Michael, Daryn R. ; Plummer, Sue ; Jack, Alison A. ; Davies, Thomas S. ; Hughes, Timothy R. ; Wang, Duolao</creatorcontrib><description>Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m
2
experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people.</description><identifier>ISSN: 1949-0976</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2021.1900997</identifier><identifier>PMID: 33764850</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Addendum ; Adult ; Aged ; Double-Blind Method ; Gastrointestinal Microbiome ; gut microbiome ; gut-lung axis ; Humans ; Middle Aged ; obesity ; Obesity - complications ; Overweight - complications ; Pandemics ; Probiotics ; Probiotics - therapeutic use ; Respiratory Tract Infections - prevention & control ; Respiratory Tract Infections - therapy ; Self Report ; upper respiratory tract infection</subject><ispartof>Gut microbes, 2021-01, Vol.13 (1), p.1-9</ispartof><rights>2021 The Author(s). Published with license by Taylor & Francis Group, LLC. 2021</rights><rights>2021 The Author(s). Published with license by Taylor & Francis Group, LLC. 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-807cb2c72a0e29798353612bb3bac95227e0edfdd48153598e9fa0cbce923c4d3</citedby><cites>FETCH-LOGICAL-c534t-807cb2c72a0e29798353612bb3bac95227e0edfdd48153598e9fa0cbce923c4d3</cites><orcidid>0000-0002-8513-2509 ; 0000-0001-6300-3100 ; 0000-0003-2799-8432 ; 0000-0001-8546-1153 ; 0000-0002-3919-6173 ; 0000-0003-2348-3490 ; 0000-0003-0739-6047 ; 0000-0003-2788-2464 ; 0000-0002-7994-5239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007143/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007143/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33764850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullish, Benjamin H.</creatorcontrib><creatorcontrib>Marchesi, Julian R.</creatorcontrib><creatorcontrib>McDonald, Julie A.K.</creatorcontrib><creatorcontrib>Pass, Daniel A.</creatorcontrib><creatorcontrib>Masetti, Giulia</creatorcontrib><creatorcontrib>Michael, Daryn R.</creatorcontrib><creatorcontrib>Plummer, Sue</creatorcontrib><creatorcontrib>Jack, Alison A.</creatorcontrib><creatorcontrib>Davies, Thomas S.</creatorcontrib><creatorcontrib>Hughes, Timothy R.</creatorcontrib><creatorcontrib>Wang, Duolao</creatorcontrib><title>Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?</title><title>Gut microbes</title><addtitle>Gut Microbes</addtitle><description>Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m
2
experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people.</description><subject>Addendum</subject><subject>Adult</subject><subject>Aged</subject><subject>Double-Blind Method</subject><subject>Gastrointestinal Microbiome</subject><subject>gut microbiome</subject><subject>gut-lung axis</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>Obesity - complications</subject><subject>Overweight - complications</subject><subject>Pandemics</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Respiratory Tract Infections - therapy</subject><subject>Self Report</subject><subject>upper respiratory tract infection</subject><issn>1949-0976</issn><issn>1949-0984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks1uEzEUhUcIRKvSRwB5ySapx_aMbRb8qKJQqRIsYG35507iamY82J5EeSTeEqdJA93gja-Oj797ZZ-qel3jZY0Fvqolk1jydkkwqZe1xFhK_qw63-sLLAV7fqp5e1ZdpnSPy2KM45a-rM4o5S0TDT6vfn-PwfiQvU0ogpstoAR9t4gwhZjBobQbphyGhEKH5mmCWGxp8lHnEHcoR20z8mMHNvswlgqFDcQt-NU6Iz06FAwkQNrNfU7vUFqHuXdoC8gAsmFM3kH04wpNf8dw84OyKT16NBUGDEX-8Kp60ek-weVxv6h-3nz-cf11cffty-31p7uFbSjLC4G5NcRyojEQyaWgDW1rYgw12sqGEA4YXOccE3VDGylAdhpbY0ESapmjF9XtgeuCvldT9IOOOxW0Vw9CiCulYxm0B9UYg4lx2nQSMwGd1Li2lEInnGk444X1_sCaZjOAszCWB-ufQJ-ejH6tVmGjBMa8ZrQA3h4BMfyaIWU1-GSh7_UIYU6KNLglom4JK9bmYLUxpBShO7WpsdqnRj2mRu1To46pKffe_Dvj6dZjRorh48FQvjnEQW9D7J3KeteH2EU9Wp8U_X-PPxqM17o</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Mullish, Benjamin H.</creator><creator>Marchesi, Julian R.</creator><creator>McDonald, Julie A.K.</creator><creator>Pass, Daniel A.</creator><creator>Masetti, Giulia</creator><creator>Michael, Daryn R.</creator><creator>Plummer, Sue</creator><creator>Jack, Alison A.</creator><creator>Davies, Thomas S.</creator><creator>Hughes, Timothy R.</creator><creator>Wang, Duolao</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8513-2509</orcidid><orcidid>https://orcid.org/0000-0001-6300-3100</orcidid><orcidid>https://orcid.org/0000-0003-2799-8432</orcidid><orcidid>https://orcid.org/0000-0001-8546-1153</orcidid><orcidid>https://orcid.org/0000-0002-3919-6173</orcidid><orcidid>https://orcid.org/0000-0003-2348-3490</orcidid><orcidid>https://orcid.org/0000-0003-0739-6047</orcidid><orcidid>https://orcid.org/0000-0003-2788-2464</orcidid><orcidid>https://orcid.org/0000-0002-7994-5239</orcidid></search><sort><creationdate>20210101</creationdate><title>Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?</title><author>Mullish, Benjamin H. ; Marchesi, Julian R. ; McDonald, Julie A.K. ; Pass, Daniel A. ; Masetti, Giulia ; Michael, Daryn R. ; Plummer, Sue ; Jack, Alison A. ; Davies, Thomas S. ; Hughes, Timothy R. ; Wang, Duolao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-807cb2c72a0e29798353612bb3bac95227e0edfdd48153598e9fa0cbce923c4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Addendum</topic><topic>Adult</topic><topic>Aged</topic><topic>Double-Blind Method</topic><topic>Gastrointestinal Microbiome</topic><topic>gut microbiome</topic><topic>gut-lung axis</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>obesity</topic><topic>Obesity - complications</topic><topic>Overweight - complications</topic><topic>Pandemics</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Respiratory Tract Infections - therapy</topic><topic>Self Report</topic><topic>upper respiratory tract infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mullish, Benjamin H.</creatorcontrib><creatorcontrib>Marchesi, Julian R.</creatorcontrib><creatorcontrib>McDonald, Julie A.K.</creatorcontrib><creatorcontrib>Pass, Daniel A.</creatorcontrib><creatorcontrib>Masetti, Giulia</creatorcontrib><creatorcontrib>Michael, Daryn R.</creatorcontrib><creatorcontrib>Plummer, Sue</creatorcontrib><creatorcontrib>Jack, Alison A.</creatorcontrib><creatorcontrib>Davies, Thomas S.</creatorcontrib><creatorcontrib>Hughes, Timothy R.</creatorcontrib><creatorcontrib>Wang, Duolao</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gut microbes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mullish, Benjamin H.</au><au>Marchesi, Julian R.</au><au>McDonald, Julie A.K.</au><au>Pass, Daniel A.</au><au>Masetti, Giulia</au><au>Michael, Daryn R.</au><au>Plummer, Sue</au><au>Jack, Alison A.</au><au>Davies, Thomas S.</au><au>Hughes, Timothy R.</au><au>Wang, Duolao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?</atitle><jtitle>Gut microbes</jtitle><addtitle>Gut Microbes</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>13</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1949-0976</issn><eissn>1949-0984</eissn><abstract>Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m
2
experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>33764850</pmid><doi>10.1080/19490976.2021.1900997</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8513-2509</orcidid><orcidid>https://orcid.org/0000-0001-6300-3100</orcidid><orcidid>https://orcid.org/0000-0003-2799-8432</orcidid><orcidid>https://orcid.org/0000-0001-8546-1153</orcidid><orcidid>https://orcid.org/0000-0002-3919-6173</orcidid><orcidid>https://orcid.org/0000-0003-2348-3490</orcidid><orcidid>https://orcid.org/0000-0003-0739-6047</orcidid><orcidid>https://orcid.org/0000-0003-2788-2464</orcidid><orcidid>https://orcid.org/0000-0002-7994-5239</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1949-0976 |
| ispartof | Gut microbes, 2021-01, Vol.13 (1), p.1-9 |
| issn | 1949-0976 1949-0984 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2506281624 |
| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Addendum Adult Aged Double-Blind Method Gastrointestinal Microbiome gut microbiome gut-lung axis Humans Middle Aged obesity Obesity - complications Overweight - complications Pandemics Probiotics Probiotics - therapeutic use Respiratory Tract Infections - prevention & control Respiratory Tract Infections - therapy Self Report upper respiratory tract infection |
| title | Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T02%3A28%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Probiotics%20reduce%20self-reported%20symptoms%20of%20upper%20respiratory%20tract%20infection%20in%20overweight%20and%20obese%20adults:%20should%20we%20be%20considering%20probiotics%20during%20viral%20pandemics?&rft.jtitle=Gut%20microbes&rft.au=Mullish,%20Benjamin%20H.&rft.date=2021-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=1949-0976&rft.eissn=1949-0984&rft_id=info:doi/10.1080/19490976.2021.1900997&rft_dat=%3Cproquest_infor%3E2506281624%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2506281624&rft_id=info:pmid/33764850&rft_doaj_id=oai_doaj_org_article_5bb02bdabf9048ef9a01c33ef8db5747&rfr_iscdi=true |