2-(2-Benzofuranyl)-2-Imidazoline Attenuates the Disruption of the Blood–Brain Barrier in EAE via NMDAR

Blood–brain barrier (BBB) disruption has been recognized as an early hallmark of multiple sclerosis (MS) pathology. Our previous studies have shown that 2-(2-Benzofuranyl)-2-imidazoline (2-BFI) protected against experimental autoimmune encephalomyelitis (EAE), a classic animal model of MS. However,...

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Veröffentlicht in:	Neurochemical research 2021-07, Vol.46 (7), p.1674-1685
Hauptverfasser:	Xia, Niange, Hua, Yingjie, Li, Jia, Chen, Yanyan, Li, Xueying, Lin, Jiahe, Xu, Huiqin, Xie, Chenglong, Wang, Xinshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Benzofurans - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Cell Biology Cell Line Context Disruption Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Female Glutamic acid receptors Imidazoles - therapeutic use Imidazoline Inflammation Membrane permeability Mice Mice, Inbred C57BL Multiple sclerosis N-Methyl-D-aspartic acid receptors Neurochemistry Neurological diseases Neurology Neurosciences Occludin - metabolism Original Paper Permeability Permeability - drug effects Phosphorylation Receptors, N-Methyl-D-Aspartate - metabolism Signal transduction Signal Transduction - drug effects Signaling Tumor necrosis factor-α
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