Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Mesenchymal stem cells (MSCs) could inhibit the proliferation of lung cancer cells. The authors' study investigated the effects of immunologically activated human umbilical cord (HUC)-MSCs on A549 lung cancer cells. HUC-MSCs were separated from the umbilical cord using the adherence method. Sur...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2023-06, Vol.38 (5), p.322-335
Hauptverfasser:	Ye, Hong, Pan, Jiongwei, Gong, Enhui, Cai, Xiaoping, Xu, Cunlai, Li, Yuling, Zheng, Hao, Cao, Zhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis CD105 antigen CD29 antigen CD44 antigen CD73 antigen Cell Differentiation Cell migration Cell proliferation Cell viability Flow cytometry Humans Imiquimod Imiquimod - metabolism Imiquimod - pharmacology Immune response Inflammation Interleukin 6 Lung cancer Lung Neoplasms - metabolism Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Metastases Metastasis NF-kappa B - metabolism NF-κB protein Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism siRNA Stem cells Surface markers TLR7 protein Toll-Like Receptor 7 - metabolism Toll-like receptors Umbilical cord
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