The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis
Abstract Study Objectives This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA). Methods We conducted a systematic search through PubMed, Medline, the Cochr...
Gespeichert in:
| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2021-08, Vol.44 (8), p.1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 1 |
| container_title | Sleep (New York, N.Y.) |
| container_volume | 44 |
| creator | Wang, Donghao Tang, Yongkang Chen, Yanghang Zhang, Sun Ma, Danjie Luo, Yateng Li, Shiwei Su, Xiaofen Wang, Xinni Liu, Chunli Zhang, Nuofu |
| description | Abstract
Study Objectives
This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA).
Methods
We conducted a systematic search through PubMed, Medline, the Cochrane Library, EMBASE, Scopus and ClinicalTrials (all searched from inception to August 15, 2020). Publications were limited to articles, clinical conferences and letters, including randomized controlled trials and retrospective studies. We used a random-effects model to calculate the odds ratio (OR) and mean difference (MD) with corresponding confidence interval (CI). Subgroup analyses were conducted to analyze the sources of heterogeneity.
Results
Eight studies fulfilled the inclusion and exclusion criteria for patients newly diagnosed with obstructive sleep apnea. Overall, the use of NBSH was associated with increased use of CPAP per night (MD = 0.62 h; 95% CI = 0.26–0.98) and use for more nights (MD = 12.08%; 95% CI = 5.27–18.88). When a study seriously affecting heterogeneity was removed, more patients adhered well with CPAP use (pooled OR = 2.48; 95% CI = 1.75–3.52) with good adherence defined as CPAP use for >4 h/night on >70% of nights. Among prescribed NBSHs, eszopiclone showed the most significant effect on CPAP adherence.
Conclusion
CPAP adherence may increase in OSA patients treated with non-benzodiazepine sedative hypnotics especially eszopiclone. The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials. |
| doi_str_mv | 10.1093/sleep/zsab077 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2506277539</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A700265128</galeid><oup_id>10.1093/sleep/zsab077</oup_id><sourcerecordid>A700265128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-8d4de216fbb97c90c28036df4e75ce35976db309aca90354c785f47b89451e663</originalsourceid><addsrcrecordid>eNqFkc9rFDEUx4Modq0evUrAi5dpk8kkmXhbFn9BoQXrecgkL27KTDJOMi27N_9zs3a1KILkEPLe5335vnwReknJGSWKnacBYDrfJ90TKR-hFeWcVKq0HqMVoYJWLSX8BD1L6YaUd6PYU3TCmBSKN2qFvl9vAYNzYDKODocYqh7CPlqv9zD5ADiB1dnfAt7uphCzNwnHgDdX6yus7RZmCAawD3gqFISc8J3PW3z5ef0Wa5x2KcNYOgbPcOvhDutg8QhZVzroYZd8eo6eOD0keHG8T9GX9--uNx-ri8sPnzbri8o0guSqtY2FmgrX90oaRUzdEiasa0ByA4wrKWzPiNJGK8J4Y2TLXSP7VjWcghDsFL25153m-G2BlLvRJwPDoAPEJXU1J6KWkjNV0Nd_oTdxmYvfAyVrwmj56wfqqx6g88HFPGtzEO3WkpBacFq3hTr7B1WOhdGbGMD5Uv9joLofMHNMaQbXTbMf9bzrKOkOkXc_I--OkRf-1dHs0o9gf9O_Mn5YPC7Tf7R-AKObtdQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2572031077</pqid></control><display><type>article</type><title>The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Wang, Donghao ; Tang, Yongkang ; Chen, Yanghang ; Zhang, Sun ; Ma, Danjie ; Luo, Yateng ; Li, Shiwei ; Su, Xiaofen ; Wang, Xinni ; Liu, Chunli ; Zhang, Nuofu</creator><creatorcontrib>Wang, Donghao ; Tang, Yongkang ; Chen, Yanghang ; Zhang, Sun ; Ma, Danjie ; Luo, Yateng ; Li, Shiwei ; Su, Xiaofen ; Wang, Xinni ; Liu, Chunli ; Zhang, Nuofu</creatorcontrib><description>Abstract
Study Objectives
This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA).
Methods
We conducted a systematic search through PubMed, Medline, the Cochrane Library, EMBASE, Scopus and ClinicalTrials (all searched from inception to August 15, 2020). Publications were limited to articles, clinical conferences and letters, including randomized controlled trials and retrospective studies. We used a random-effects model to calculate the odds ratio (OR) and mean difference (MD) with corresponding confidence interval (CI). Subgroup analyses were conducted to analyze the sources of heterogeneity.
Results
Eight studies fulfilled the inclusion and exclusion criteria for patients newly diagnosed with obstructive sleep apnea. Overall, the use of NBSH was associated with increased use of CPAP per night (MD = 0.62 h; 95% CI = 0.26–0.98) and use for more nights (MD = 12.08%; 95% CI = 5.27–18.88). When a study seriously affecting heterogeneity was removed, more patients adhered well with CPAP use (pooled OR = 2.48; 95% CI = 1.75–3.52) with good adherence defined as CPAP use for >4 h/night on >70% of nights. Among prescribed NBSHs, eszopiclone showed the most significant effect on CPAP adherence.
Conclusion
CPAP adherence may increase in OSA patients treated with non-benzodiazepine sedative hypnotics especially eszopiclone. The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsab077</identifier><identifier>PMID: 33769549</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Anesthesia ; Benzodiazepines ; Continuous positive airway pressure ; Eszopiclone ; Meta-analysis ; Patient compliance ; Sleep apnea ; Sleep apnea syndromes ; Systematic review ; Zaleplon</subject><ispartof>Sleep (New York, N.Y.), 2021-08, Vol.44 (8), p.1</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2021</rights><rights>Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-8d4de216fbb97c90c28036df4e75ce35976db309aca90354c785f47b89451e663</citedby><cites>FETCH-LOGICAL-c460t-8d4de216fbb97c90c28036df4e75ce35976db309aca90354c785f47b89451e663</cites><orcidid>0000-0003-2908-9865 ; 0000-0002-7219-2676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33769549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Donghao</creatorcontrib><creatorcontrib>Tang, Yongkang</creatorcontrib><creatorcontrib>Chen, Yanghang</creatorcontrib><creatorcontrib>Zhang, Sun</creatorcontrib><creatorcontrib>Ma, Danjie</creatorcontrib><creatorcontrib>Luo, Yateng</creatorcontrib><creatorcontrib>Li, Shiwei</creatorcontrib><creatorcontrib>Su, Xiaofen</creatorcontrib><creatorcontrib>Wang, Xinni</creatorcontrib><creatorcontrib>Liu, Chunli</creatorcontrib><creatorcontrib>Zhang, Nuofu</creatorcontrib><title>The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Abstract
Study Objectives
This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA).
Methods
We conducted a systematic search through PubMed, Medline, the Cochrane Library, EMBASE, Scopus and ClinicalTrials (all searched from inception to August 15, 2020). Publications were limited to articles, clinical conferences and letters, including randomized controlled trials and retrospective studies. We used a random-effects model to calculate the odds ratio (OR) and mean difference (MD) with corresponding confidence interval (CI). Subgroup analyses were conducted to analyze the sources of heterogeneity.
Results
Eight studies fulfilled the inclusion and exclusion criteria for patients newly diagnosed with obstructive sleep apnea. Overall, the use of NBSH was associated with increased use of CPAP per night (MD = 0.62 h; 95% CI = 0.26–0.98) and use for more nights (MD = 12.08%; 95% CI = 5.27–18.88). When a study seriously affecting heterogeneity was removed, more patients adhered well with CPAP use (pooled OR = 2.48; 95% CI = 1.75–3.52) with good adherence defined as CPAP use for >4 h/night on >70% of nights. Among prescribed NBSHs, eszopiclone showed the most significant effect on CPAP adherence.
Conclusion
CPAP adherence may increase in OSA patients treated with non-benzodiazepine sedative hypnotics especially eszopiclone. The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials.</description><subject>Analysis</subject><subject>Anesthesia</subject><subject>Benzodiazepines</subject><subject>Continuous positive airway pressure</subject><subject>Eszopiclone</subject><subject>Meta-analysis</subject><subject>Patient compliance</subject><subject>Sleep apnea</subject><subject>Sleep apnea syndromes</subject><subject>Systematic review</subject><subject>Zaleplon</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9rFDEUx4Modq0evUrAi5dpk8kkmXhbFn9BoQXrecgkL27KTDJOMi27N_9zs3a1KILkEPLe5335vnwReknJGSWKnacBYDrfJ90TKR-hFeWcVKq0HqMVoYJWLSX8BD1L6YaUd6PYU3TCmBSKN2qFvl9vAYNzYDKODocYqh7CPlqv9zD5ADiB1dnfAt7uphCzNwnHgDdX6yus7RZmCAawD3gqFISc8J3PW3z5ef0Wa5x2KcNYOgbPcOvhDutg8QhZVzroYZd8eo6eOD0keHG8T9GX9--uNx-ri8sPnzbri8o0guSqtY2FmgrX90oaRUzdEiasa0ByA4wrKWzPiNJGK8J4Y2TLXSP7VjWcghDsFL25153m-G2BlLvRJwPDoAPEJXU1J6KWkjNV0Nd_oTdxmYvfAyVrwmj56wfqqx6g88HFPGtzEO3WkpBacFq3hTr7B1WOhdGbGMD5Uv9joLofMHNMaQbXTbMf9bzrKOkOkXc_I--OkRf-1dHs0o9gf9O_Mn5YPC7Tf7R-AKObtdQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Wang, Donghao</creator><creator>Tang, Yongkang</creator><creator>Chen, Yanghang</creator><creator>Zhang, Sun</creator><creator>Ma, Danjie</creator><creator>Luo, Yateng</creator><creator>Li, Shiwei</creator><creator>Su, Xiaofen</creator><creator>Wang, Xinni</creator><creator>Liu, Chunli</creator><creator>Zhang, Nuofu</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2908-9865</orcidid><orcidid>https://orcid.org/0000-0002-7219-2676</orcidid></search><sort><creationdate>20210801</creationdate><title>The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis</title><author>Wang, Donghao ; Tang, Yongkang ; Chen, Yanghang ; Zhang, Sun ; Ma, Danjie ; Luo, Yateng ; Li, Shiwei ; Su, Xiaofen ; Wang, Xinni ; Liu, Chunli ; Zhang, Nuofu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-8d4de216fbb97c90c28036df4e75ce35976db309aca90354c785f47b89451e663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Anesthesia</topic><topic>Benzodiazepines</topic><topic>Continuous positive airway pressure</topic><topic>Eszopiclone</topic><topic>Meta-analysis</topic><topic>Patient compliance</topic><topic>Sleep apnea</topic><topic>Sleep apnea syndromes</topic><topic>Systematic review</topic><topic>Zaleplon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Donghao</creatorcontrib><creatorcontrib>Tang, Yongkang</creatorcontrib><creatorcontrib>Chen, Yanghang</creatorcontrib><creatorcontrib>Zhang, Sun</creatorcontrib><creatorcontrib>Ma, Danjie</creatorcontrib><creatorcontrib>Luo, Yateng</creatorcontrib><creatorcontrib>Li, Shiwei</creatorcontrib><creatorcontrib>Su, Xiaofen</creatorcontrib><creatorcontrib>Wang, Xinni</creatorcontrib><creatorcontrib>Liu, Chunli</creatorcontrib><creatorcontrib>Zhang, Nuofu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Donghao</au><au>Tang, Yongkang</au><au>Chen, Yanghang</au><au>Zhang, Sun</au><au>Ma, Danjie</au><au>Luo, Yateng</au><au>Li, Shiwei</au><au>Su, Xiaofen</au><au>Wang, Xinni</au><au>Liu, Chunli</au><au>Zhang, Nuofu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>44</volume><issue>8</issue><spage>1</spage><pages>1-</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Study Objectives
This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA).
Methods
We conducted a systematic search through PubMed, Medline, the Cochrane Library, EMBASE, Scopus and ClinicalTrials (all searched from inception to August 15, 2020). Publications were limited to articles, clinical conferences and letters, including randomized controlled trials and retrospective studies. We used a random-effects model to calculate the odds ratio (OR) and mean difference (MD) with corresponding confidence interval (CI). Subgroup analyses were conducted to analyze the sources of heterogeneity.
Results
Eight studies fulfilled the inclusion and exclusion criteria for patients newly diagnosed with obstructive sleep apnea. Overall, the use of NBSH was associated with increased use of CPAP per night (MD = 0.62 h; 95% CI = 0.26–0.98) and use for more nights (MD = 12.08%; 95% CI = 5.27–18.88). When a study seriously affecting heterogeneity was removed, more patients adhered well with CPAP use (pooled OR = 2.48; 95% CI = 1.75–3.52) with good adherence defined as CPAP use for >4 h/night on >70% of nights. Among prescribed NBSHs, eszopiclone showed the most significant effect on CPAP adherence.
Conclusion
CPAP adherence may increase in OSA patients treated with non-benzodiazepine sedative hypnotics especially eszopiclone. The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33769549</pmid><doi>10.1093/sleep/zsab077</doi><orcidid>https://orcid.org/0000-0003-2908-9865</orcidid><orcidid>https://orcid.org/0000-0002-7219-2676</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2021-08, Vol.44 (8), p.1 |
| issn | 0161-8105 1550-9109 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2506277539 |
| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Analysis Anesthesia Benzodiazepines Continuous positive airway pressure Eszopiclone Meta-analysis Patient compliance Sleep apnea Sleep apnea syndromes Systematic review Zaleplon |
| title | The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T14%3A37%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20non-benzodiazepine%20sedative%20hypnotics%20on%20CPAP%20adherence%20in%20patients%20with%20OSA:%20a%20systematic%20review%20and%20meta-analysis&rft.jtitle=Sleep%20(New%20York,%20N.Y.)&rft.au=Wang,%20Donghao&rft.date=2021-08-01&rft.volume=44&rft.issue=8&rft.spage=1&rft.pages=1-&rft.issn=0161-8105&rft.eissn=1550-9109&rft_id=info:doi/10.1093/sleep/zsab077&rft_dat=%3Cgale_proqu%3EA700265128%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2572031077&rft_id=info:pmid/33769549&rft_galeid=A700265128&rft_oup_id=10.1093/sleep/zsab077&rfr_iscdi=true |