Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors

The neuronal glycine transporter GlyT2 modulates inhibitory glycinergic neurotransmission and plays a key role in regulating nociceptive signal progression. The cholinergic system acting through muscarinic acetylcholine receptors (mAChRs) also mediates important regulations of nociceptive transmissi...

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Veröffentlicht in:	Neurochemical research 2022, Vol.47 (1), p.190-203
Hauptverfasser:	Jiménez, Esperanza, Fornés, Amparo, Felipe, Raquel, Núñez, Enrique, Aragón, Carmen, López-Corcuera, Beatriz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Animals Binding sites Biochemistry Biomedical and Life Sciences Biomedicine Calcium Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium homeostasis Carbachol Cell Biology Cholinergic transmission Cholinergics Depletion Down-regulation Endoplasmic reticulum Glycine Glycine Plasma Membrane Transport Proteins - metabolism Glycine transporter Homeostasis Membranes Mitochondria Na+/Ca2+ exchanger Neurochemistry Neurology Neurons - metabolism Neurosciences Neurotransmission Original Paper Pain Pain perception Rats Rats, Wistar Receptors Receptors, Muscarinic - metabolism Sodium Spinal cord Thapsigargin
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