Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model

Purpose Advanced ovarian clear cell carcinoma (OCCC) is a recalcitrant disease, often resistant to the first-line platinum-based therapy. Using a novel patient-derived orthotopic xenograft (PDOX) nude-mouse model of OCCC, we tested whether oral-recombinant methioninase (o-rMETase) could enhance the...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2021-07, Vol.88 (1), p.61-67
Hauptverfasser:	Sugisawa, Norihiko, Higuchi, Takashi, Han, Qinghong, Hozumi, Chihiro, Yamamoto, Jun, Tashiro, Yoshihiko, Nishino, Hiroto, Kawaguchi, Kei, Bouvet, Michael, Murata, Takuya, Unno, Michiaki, Hoffman, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Cancer Cancer Research Health services Injection Medicine Medicine & Public Health Oncology Original Article Ovaries Paclitaxel Patients Pharmacology/Toxicology Platinum Therapy Tumors Xenografts Xenotransplantation
Online-Zugang:	Volltext
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