Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China

Apurinic/apyrimidinic endonuclease 1/redox-factor 1 ( APE1/Ref-1 ) gene encodes a multifunctional protein involved in the DNA base excision repair (BER) pathway, which initiates repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone. APE1/R...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2021-09, Vol.28 (9), p.2592-2601
Hauptverfasser:	Wang, Xiuwei, Yue, Huixuan, Li, Shen, Guo, Jin, Guan, Zhen, Zhu, Zhiqiang, Niu, Bo, Zhang, Ting, Wang, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asians - genetics Biomarkers - blood Case-Control Studies China - epidemiology DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics Embryology Female Folic Acid - blood Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Male Maternal Fetal Medicine/Biology: Original Article Medicine Medicine & Public Health Neural Tube Defects - blood Neural Tube Defects - diagnosis Neural Tube Defects - ethnology Neural Tube Defects - genetics Obstetrics/Perinatology/Midwifery Polymorphism, Single Nucleotide Reproductive Medicine Risk Assessment Risk Factors Young Adult
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