Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Recent studies in both mice and humans have suggested that gut microbiota could modulate tumor responsiveness to chemo- or immunotherapies. However, the underlying mechanism is not clear yet. Here, we found that gut microbial metabolites, especially butyrate, could promote the efficacy of oxaliplati...

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Veröffentlicht in:	Cell metabolism 2021-05, Vol.33 (5), p.988-1000.e7
Hauptverfasser:	He, Yao, Fu, Liuhui, Li, Yiping, Wang, Wenyan, Gong, Mingli, Zhang, Jing, Dong, Xin, Huang, Jiaoyan, Wang, Quanbo, Mackay, Charles R., Fu, Yang-Xin, Chen, Yun, Guo, Xiaohuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antineoplastic Agents - therapeutic use antitumor therapy efficacy butyrate Butyrates - blood Butyrates - pharmacology CD8+ T cell CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Biology Cell Line, Tumor Endocrinology & Metabolism gut microbial metabolites Humans ID2 IL-12 Inhibitor of Differentiation Protein 2 - deficiency Inhibitor of Differentiation Protein 2 - genetics Inhibitor of Differentiation Protein 2 - metabolism Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-12 - metabolism Life Sciences & Biomedicine Lymphocytes, Tumor-Infiltrating - immunology Male Metabolome - drug effects Mice Mice, Inbred C57BL Mice, Knockout Neoplasms - drug therapy Oxaliplatin - therapeutic use Science & Technology Signal Transduction - drug effects Tumor Microenvironment
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