Investigating plasma volume expanders as novel macromolecular MRI‐CEST contrast agents for tumor contrast‐enhanced imaging

Purpose The aim of this study was to investigate two clinically approved plasma volume expanders (dextran 70 and voluven) as macromolecular MRI‐chemical exchange saturation transfer (CEST) contrast agents to assess tumor vascular properties. Methods CEST contrast efficiency of both molecules (6% w/v...

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Veröffentlicht in:	Magnetic resonance in medicine 2021-08, Vol.86 (2), p.995-1007
Hauptverfasser:	Consolino, Lorena, Irrera, Pietro, Romdhane, Feriel, Anemone, Annasofia, Longo, Dario Livio
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenocarcinoma Animals Blood chemical exchange saturation transfer Contrast agents Contrast Media Dextran Dextrans Expanders Foreign exchange rates Gadolinium In vivo methods and tests Irradiation macromolecular agent Macromolecules Magnetic Resonance Imaging Mice Neoplasms - diagnostic imaging Perfusion pH effects Plasma Substitutes plasma volume expander Protons Radiation Saturation Spatial analysis Tumors Vascularization
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