HDAC3 protects against atherosclerosis through inhibition of inflammation via the microRNA-19b/PPARγ/NF-κB axis

Atherosclerosis (AS) is one of the leading causes of cardiovascular diseases. Studies have revealed critical roles of microRNAs (miRNAs) in the progression of AS. This study was conducted to elucidate the role and mechanism by which miR-19b influences AS. Human umbilical vein endothelial cells (HUVE...

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Veröffentlicht in:	Atherosclerosis 2021-04, Vol.323, p.1-12
Hauptverfasser:	Wang, Jinpeng, Xu, Xiaofei, Li, Ping, Zhang, Beilin, Zhang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - genetics Atherosclerosis - prevention & control Histone deacetylase 3 Histone Deacetylases Human Umbilical Vein Endothelial Cells Humans Inflammation Inflammation - genetics Lipoproteins, LDL Mice Mice, Knockout, ApoE microRNA-19b MicroRNAs - genetics NF-kappa B Nuclear factor κB/p65 Peroxisome proliferator-activated receptor γ PPAR gamma - genetics
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