In-hospital outcomes of late referrals for established bronchopulmonary dysplasia
Objective To determine the in-hospital outcomes for patients with established bronchopulmonary dysplasia (BPD) referred late for severe disease. Study design Retrospective cohort study of patients with established BPD referred to our center after 36 weeks PMA. Result Among 71 patients with BPD refer...
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| Veröffentlicht in: | Journal of perinatology 2021-08, Vol.41 (8), p.1972-1982 |
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| container_end_page | 1982 |
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| container_issue | 8 |
| container_start_page | 1972 |
| container_title | Journal of perinatology |
| container_volume | 41 |
| creator | Kielt, Matthew J. Logan, J. Wells Backes, Carl H. Reber, Kristina M. Nelin, Leif D. Shepherd, Edward G. |
| description | Objective
To determine the in-hospital outcomes for patients with established bronchopulmonary dysplasia (BPD) referred late for severe disease.
Study design
Retrospective cohort study of patients with established BPD referred to our center after 36 weeks PMA.
Result
Among 71 patients with BPD referred to our center after 36 weeks PMA between 2010 and 2018, the median PMA was 47 weeks (IQR, 42, 53) and the median respiratory severity score was 8.1 (IQR 4.5, 11.0) on admission. Survival in this cohort was 92%. Most survivors were discharged home without the need for positive pressure respiratory support (77%) or pulmonary vasodilators (89%). For survivors, we observed a significant improvement in median
z
-scores for length (−6.7 vs −3.3,
p
|
| doi_str_mv | 10.1038/s41372-021-01041-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2504775481</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A670901421</galeid><sourcerecordid>A670901421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-bd5fc5c6f131cd09cd9e9a5ab6d573ac77ce53d862730c27d23528ffbdce91023</originalsourceid><addsrcrecordid>eNp9kU1rFjEUhYNY7Gv1D7iQAaG4Sc13ZpalWC0UiqDrkMlHJyWTjMnMov_evL7VWhHJ4kLucw733gPAG4zOMKL9h8owlQQigiHCiGEonoEdZlJAzhl9DnZIMgp7ysQxeFnrHUL7pnwBjimVvKfDsANfrhKccl3CqmOXt9Xk2dUu-y7q1XXFeVeKjrXzuXSurnqMoU7OdmPJyUx52eKcky73nb2vS9Q16FfgyDeFe_1QT8C3y49fLz7D65tPVxfn19AwSVc4Wu4NN8Jjio1Fg7GDGzTXo7BcUm2kNI5T2wsiKTJEWkI56b0frXEDRoSegPcH36Xk71ubTc2hGhejTi5vVRGOmJSc9bih7_5C7_JWUpuuUbwngsuhf6RudXQqJJ_Xos3eVJ0LiYZ2PbL3OvsH1Z51czA5OR_a_xPB6R-Cyem4TjXHbQ051acgOYCm5Frb6dVSwtxuqzBS-8DVIXDVAlc_A1eiid4-rLaNs7O_Jb8SbgA9ALW10q0rj7v_x_YHh9u0Yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2558265798</pqid></control><display><type>article</type><title>In-hospital outcomes of late referrals for established bronchopulmonary dysplasia</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kielt, Matthew J. ; Logan, J. Wells ; Backes, Carl H. ; Reber, Kristina M. ; Nelin, Leif D. ; Shepherd, Edward G.</creator><creatorcontrib>Kielt, Matthew J. ; Logan, J. Wells ; Backes, Carl H. ; Reber, Kristina M. ; Nelin, Leif D. ; Shepherd, Edward G.</creatorcontrib><description>Objective
To determine the in-hospital outcomes for patients with established bronchopulmonary dysplasia (BPD) referred late for severe disease.
Study design
Retrospective cohort study of patients with established BPD referred to our center after 36 weeks PMA.
Result
Among 71 patients with BPD referred to our center after 36 weeks PMA between 2010 and 2018, the median PMA was 47 weeks (IQR, 42, 53) and the median respiratory severity score was 8.1 (IQR 4.5, 11.0) on admission. Survival in this cohort was 92%. Most survivors were discharged home without the need for positive pressure respiratory support (77%) or pulmonary vasodilators (89%). For survivors, we observed a significant improvement in median
z
-scores for length (−6.7 vs −3.3,
p
< 0.0001) between admission and discharge.
Conclusion
Despite presenting relatively late with a high degree of illness severity, nearly all patients in this cohort survived to hospital discharge with improvement in comorbidities.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-021-01041-6</identifier><identifier>PMID: 33758399</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/699/1785 ; Bronchopulmonary dysplasia ; Bronchopulmonary Dysplasia - epidemiology ; Bronchopulmonary Dysplasia - therapy ; Care and treatment ; Dysplasia ; Hospital patients ; Hospitals ; Humans ; Infant, Newborn ; Intermittent Positive-Pressure Ventilation ; Lung diseases ; Medical referral ; Medicine ; Medicine & Public Health ; Patient outcomes ; Patients ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Referral and Consultation ; Retrospective Studies ; Statistics ; Survival ; Vasodilators</subject><ispartof>Journal of perinatology, 2021-08, Vol.41 (8), p.1972-1982</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-bd5fc5c6f131cd09cd9e9a5ab6d573ac77ce53d862730c27d23528ffbdce91023</citedby><cites>FETCH-LOGICAL-c473t-bd5fc5c6f131cd09cd9e9a5ab6d573ac77ce53d862730c27d23528ffbdce91023</cites><orcidid>0000-0001-6816-7059 ; 0000-0001-5575-3112 ; 0000-0002-4568-9070 ; 0000-0001-6929-704X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-021-01041-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-021-01041-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33758399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kielt, Matthew J.</creatorcontrib><creatorcontrib>Logan, J. Wells</creatorcontrib><creatorcontrib>Backes, Carl H.</creatorcontrib><creatorcontrib>Reber, Kristina M.</creatorcontrib><creatorcontrib>Nelin, Leif D.</creatorcontrib><creatorcontrib>Shepherd, Edward G.</creatorcontrib><title>In-hospital outcomes of late referrals for established bronchopulmonary dysplasia</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To determine the in-hospital outcomes for patients with established bronchopulmonary dysplasia (BPD) referred late for severe disease.
Study design
Retrospective cohort study of patients with established BPD referred to our center after 36 weeks PMA.
Result
Among 71 patients with BPD referred to our center after 36 weeks PMA between 2010 and 2018, the median PMA was 47 weeks (IQR, 42, 53) and the median respiratory severity score was 8.1 (IQR 4.5, 11.0) on admission. Survival in this cohort was 92%. Most survivors were discharged home without the need for positive pressure respiratory support (77%) or pulmonary vasodilators (89%). For survivors, we observed a significant improvement in median
z
-scores for length (−6.7 vs −3.3,
p
< 0.0001) between admission and discharge.
Conclusion
Despite presenting relatively late with a high degree of illness severity, nearly all patients in this cohort survived to hospital discharge with improvement in comorbidities.</description><subject>692/308/409</subject><subject>692/699/1785</subject><subject>Bronchopulmonary dysplasia</subject><subject>Bronchopulmonary Dysplasia - epidemiology</subject><subject>Bronchopulmonary Dysplasia - therapy</subject><subject>Care and treatment</subject><subject>Dysplasia</subject><subject>Hospital patients</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intermittent Positive-Pressure Ventilation</subject><subject>Lung diseases</subject><subject>Medical referral</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Referral and Consultation</subject><subject>Retrospective Studies</subject><subject>Statistics</subject><subject>Survival</subject><subject>Vasodilators</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFjEUhYNY7Gv1D7iQAaG4Sc13ZpalWC0UiqDrkMlHJyWTjMnMov_evL7VWhHJ4kLucw733gPAG4zOMKL9h8owlQQigiHCiGEonoEdZlJAzhl9DnZIMgp7ysQxeFnrHUL7pnwBjimVvKfDsANfrhKccl3CqmOXt9Xk2dUu-y7q1XXFeVeKjrXzuXSurnqMoU7OdmPJyUx52eKcky73nb2vS9Q16FfgyDeFe_1QT8C3y49fLz7D65tPVxfn19AwSVc4Wu4NN8Jjio1Fg7GDGzTXo7BcUm2kNI5T2wsiKTJEWkI56b0frXEDRoSegPcH36Xk71ubTc2hGhejTi5vVRGOmJSc9bih7_5C7_JWUpuuUbwngsuhf6RudXQqJJ_Xos3eVJ0LiYZ2PbL3OvsH1Z51czA5OR_a_xPB6R-Cyem4TjXHbQ051acgOYCm5Frb6dVSwtxuqzBS-8DVIXDVAlc_A1eiid4-rLaNs7O_Jb8SbgA9ALW10q0rj7v_x_YHh9u0Yg</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Kielt, Matthew J.</creator><creator>Logan, J. 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Wells</creatorcontrib><creatorcontrib>Backes, Carl H.</creatorcontrib><creatorcontrib>Reber, Kristina M.</creatorcontrib><creatorcontrib>Nelin, Leif D.</creatorcontrib><creatorcontrib>Shepherd, Edward G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kielt, Matthew J.</au><au>Logan, J. Wells</au><au>Backes, Carl H.</au><au>Reber, Kristina M.</au><au>Nelin, Leif D.</au><au>Shepherd, Edward G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-hospital outcomes of late referrals for established bronchopulmonary dysplasia</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>41</volume><issue>8</issue><spage>1972</spage><epage>1982</epage><pages>1972-1982</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To determine the in-hospital outcomes for patients with established bronchopulmonary dysplasia (BPD) referred late for severe disease.
Study design
Retrospective cohort study of patients with established BPD referred to our center after 36 weeks PMA.
Result
Among 71 patients with BPD referred to our center after 36 weeks PMA between 2010 and 2018, the median PMA was 47 weeks (IQR, 42, 53) and the median respiratory severity score was 8.1 (IQR 4.5, 11.0) on admission. Survival in this cohort was 92%. Most survivors were discharged home without the need for positive pressure respiratory support (77%) or pulmonary vasodilators (89%). For survivors, we observed a significant improvement in median
z
-scores for length (−6.7 vs −3.3,
p
< 0.0001) between admission and discharge.
Conclusion
Despite presenting relatively late with a high degree of illness severity, nearly all patients in this cohort survived to hospital discharge with improvement in comorbidities.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33758399</pmid><doi>10.1038/s41372-021-01041-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6816-7059</orcidid><orcidid>https://orcid.org/0000-0001-5575-3112</orcidid><orcidid>https://orcid.org/0000-0002-4568-9070</orcidid><orcidid>https://orcid.org/0000-0001-6929-704X</orcidid></addata></record> |
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| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2021-08, Vol.41 (8), p.1972-1982 |
| issn | 0743-8346 1476-5543 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 692/308/409 692/699/1785 Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - epidemiology Bronchopulmonary Dysplasia - therapy Care and treatment Dysplasia Hospital patients Hospitals Humans Infant, Newborn Intermittent Positive-Pressure Ventilation Lung diseases Medical referral Medicine Medicine & Public Health Patient outcomes Patients Pediatric research Pediatric Surgery Pediatrics Referral and Consultation Retrospective Studies Statistics Survival Vasodilators |
| title | In-hospital outcomes of late referrals for established bronchopulmonary dysplasia |
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