Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease
Background The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor‐15 (GDF‐15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameter...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-07, Vol.75 (7), p.e14180-n/a |
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| creator | Yeh, Kuan‐Hung Chang, Yao‐Ting Juang, Jyh‐Ming Jimmy Chiang, Fu‐Tien Teng, Ming‐Sheng Wu, Semon Lin, Jeng‐Feng Ko, Yu‐Lin |
| description | Background
The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor‐15 (GDF‐15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.
Subjects and methods
This study included 487 patients with angiographically confirmed CAD. QTc was calculated using the Bazett formula. Multiple biochemistries and GDF‐15 levels were measured. The primary endpoint was total mortality, and the secondary endpoints comprised the combination of total mortality, myocardial infarction and hospitalisation for heart failure and stroke.
Results
The mean follow‐up period was 1029 ± 343 days (5‐1692 days), during which 21 patients died and 47 had secondary endpoints. ROC curve analysis for the optimal cut‐off value of primary endpoint is 1.12 ng/mL for GDF‐15 (AUC = 0.787, P = 9.0 × 10−6) and 438.5 msec for QTc (AUC = 0.698, P = .002). Utilising linear regression, QTc has a positive correlation with Log‐GDF‐15 (r = .216, P = 1.0 × 10−6). Utilising Kaplan‐Meier analysis, both QTc interval and GDF‐15 level are significant predictors for primary end point (P = .000194, P = 2.0 × 10−6, respectively) and secondary endpoint (P = .00028, P = 6.15 × 10−8, respectively). When combined these two parameters together, a significant synergistic predictive power was noted for primary and secondary endpoint (P = 2.31 × 10−7, P = 1.26 × 10−8, respectively). This combined strategy also showed significant correlation with the severity of CAD (P |
| doi_str_mv | 10.1111/ijcp.14180 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2504771666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2504771666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3160-5aeb7d9afd7061a6ef153bfe5cb0b127112884b7c26f9fcff26d4f38e64e03b53</originalsourceid><addsrcrecordid>eNp9kU1u1DAYhiMEoqWw4QDIEhuElGLHf5klGkEpqgRIZR05zueMR4492M5U2XGEnofjcBJcUliwwBt78XyPX_utqucEn5Oy3ti9PpwTRlr8oDolkjU1aRh5WM5UtDXHlJxUT1LaY9xw3uLH1Qmlkm8o3pxWP7Zh6q2HAekQI-hcTl-ukfUZ4lE5pPyAxhhu8g4N1hiI4LNV2QaPjNI5xJ_fbwlHDo7g0E4llBYPcbQpW40OEQarsz0CKq4ZkAkRueDHMlT8Ewpz1mECFEy5aLRhjOqws1o5t5Q83tg4rcmCV3FBKpappQRJoBI8rR4Z5RI8u9_Pqq_v311vP9RXny4ut2-vak2JwDVX0Mtho8wgsSBKgCGc9ga47nFPGklI07asl7oRZmO0MY0YmKEtCAaY9pyeVa9W7yGGbzOk3E02aXBOeQhz6hqOmZRECFHQl_-g-zBHX9IVirWSyaZlhXq9UjqGlCKY7hDtVB7YEdzdNdrdNdr9brTAL-6Vc18-4y_6p8ICkBW4sQ6W_6i6y4_bz6v0F1SwspI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2548747284</pqid></control><display><type>article</type><title>Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease</title><source>MEDLINE</source><source>Wiley Blackwell Journals</source><creator>Yeh, Kuan‐Hung ; Chang, Yao‐Ting ; Juang, Jyh‐Ming Jimmy ; Chiang, Fu‐Tien ; Teng, Ming‐Sheng ; Wu, Semon ; Lin, Jeng‐Feng ; Ko, Yu‐Lin</creator><creatorcontrib>Yeh, Kuan‐Hung ; Chang, Yao‐Ting ; Juang, Jyh‐Ming Jimmy ; Chiang, Fu‐Tien ; Teng, Ming‐Sheng ; Wu, Semon ; Lin, Jeng‐Feng ; Ko, Yu‐Lin</creatorcontrib><description>Background
The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor‐15 (GDF‐15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.
Subjects and methods
This study included 487 patients with angiographically confirmed CAD. QTc was calculated using the Bazett formula. Multiple biochemistries and GDF‐15 levels were measured. The primary endpoint was total mortality, and the secondary endpoints comprised the combination of total mortality, myocardial infarction and hospitalisation for heart failure and stroke.
Results
The mean follow‐up period was 1029 ± 343 days (5‐1692 days), during which 21 patients died and 47 had secondary endpoints. ROC curve analysis for the optimal cut‐off value of primary endpoint is 1.12 ng/mL for GDF‐15 (AUC = 0.787, P = 9.0 × 10−6) and 438.5 msec for QTc (AUC = 0.698, P = .002). Utilising linear regression, QTc has a positive correlation with Log‐GDF‐15 (r = .216, P = 1.0 × 10−6). Utilising Kaplan‐Meier analysis, both QTc interval and GDF‐15 level are significant predictors for primary end point (P = .000194, P = 2.0 × 10−6, respectively) and secondary endpoint (P = .00028, P = 6.15 × 10−8, respectively). When combined these two parameters together, a significant synergistic predictive power was noted for primary and secondary endpoint (P = 2.31 × 10−7, P = 1.26 × 10−8, respectively). This combined strategy also showed significant correlation with the severity of CAD (P < .001).
Conclusion
In Chinese patient with angiographically confirmed CAD, a combined strategy utilising an ECG parameter (QTc) and a circulating biomarker (GDF‐15) has good correlation with the severity of CAD, and improves the predictive power for total mortality.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14180</identifier><identifier>PMID: 33759309</identifier><language>eng</language><publisher>India: Hindawi Limited</publisher><subject>Biomarkers ; Cardiovascular disease ; Cerebral infarction ; Congestive heart failure ; Coronary artery ; Coronary Artery Disease - diagnostic imaging ; Coronary vessels ; EKG ; Electrocardiography ; Fibrosis ; Growth Differentiation Factor 15 ; Heart Failure ; Humans ; Mortality ; Myocardial Infarction ; Prognosis ; Ventricle</subject><ispartof>International journal of clinical practice (Esher), 2021-07, Vol.75 (7), p.e14180-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3160-5aeb7d9afd7061a6ef153bfe5cb0b127112884b7c26f9fcff26d4f38e64e03b53</cites><orcidid>0000-0002-8218-6827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14180$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14180$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33759309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Kuan‐Hung</creatorcontrib><creatorcontrib>Chang, Yao‐Ting</creatorcontrib><creatorcontrib>Juang, Jyh‐Ming Jimmy</creatorcontrib><creatorcontrib>Chiang, Fu‐Tien</creatorcontrib><creatorcontrib>Teng, Ming‐Sheng</creatorcontrib><creatorcontrib>Wu, Semon</creatorcontrib><creatorcontrib>Lin, Jeng‐Feng</creatorcontrib><creatorcontrib>Ko, Yu‐Lin</creatorcontrib><title>Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Background
The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor‐15 (GDF‐15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.
Subjects and methods
This study included 487 patients with angiographically confirmed CAD. QTc was calculated using the Bazett formula. Multiple biochemistries and GDF‐15 levels were measured. The primary endpoint was total mortality, and the secondary endpoints comprised the combination of total mortality, myocardial infarction and hospitalisation for heart failure and stroke.
Results
The mean follow‐up period was 1029 ± 343 days (5‐1692 days), during which 21 patients died and 47 had secondary endpoints. ROC curve analysis for the optimal cut‐off value of primary endpoint is 1.12 ng/mL for GDF‐15 (AUC = 0.787, P = 9.0 × 10−6) and 438.5 msec for QTc (AUC = 0.698, P = .002). Utilising linear regression, QTc has a positive correlation with Log‐GDF‐15 (r = .216, P = 1.0 × 10−6). Utilising Kaplan‐Meier analysis, both QTc interval and GDF‐15 level are significant predictors for primary end point (P = .000194, P = 2.0 × 10−6, respectively) and secondary endpoint (P = .00028, P = 6.15 × 10−8, respectively). When combined these two parameters together, a significant synergistic predictive power was noted for primary and secondary endpoint (P = 2.31 × 10−7, P = 1.26 × 10−8, respectively). This combined strategy also showed significant correlation with the severity of CAD (P < .001).
Conclusion
In Chinese patient with angiographically confirmed CAD, a combined strategy utilising an ECG parameter (QTc) and a circulating biomarker (GDF‐15) has good correlation with the severity of CAD, and improves the predictive power for total mortality.</description><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cerebral infarction</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary vessels</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Fibrosis</subject><subject>Growth Differentiation Factor 15</subject><subject>Heart Failure</subject><subject>Humans</subject><subject>Mortality</subject><subject>Myocardial Infarction</subject><subject>Prognosis</subject><subject>Ventricle</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1u1DAYhiMEoqWw4QDIEhuElGLHf5klGkEpqgRIZR05zueMR4492M5U2XGEnofjcBJcUliwwBt78XyPX_utqucEn5Oy3ti9PpwTRlr8oDolkjU1aRh5WM5UtDXHlJxUT1LaY9xw3uLH1Qmlkm8o3pxWP7Zh6q2HAekQI-hcTl-ukfUZ4lE5pPyAxhhu8g4N1hiI4LNV2QaPjNI5xJ_fbwlHDo7g0E4llBYPcbQpW40OEQarsz0CKq4ZkAkRueDHMlT8Ewpz1mECFEy5aLRhjOqws1o5t5Q83tg4rcmCV3FBKpappQRJoBI8rR4Z5RI8u9_Pqq_v311vP9RXny4ut2-vak2JwDVX0Mtho8wgsSBKgCGc9ga47nFPGklI07asl7oRZmO0MY0YmKEtCAaY9pyeVa9W7yGGbzOk3E02aXBOeQhz6hqOmZRECFHQl_-g-zBHX9IVirWSyaZlhXq9UjqGlCKY7hDtVB7YEdzdNdrdNdr9brTAL-6Vc18-4y_6p8ICkBW4sQ6W_6i6y4_bz6v0F1SwspI</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Yeh, Kuan‐Hung</creator><creator>Chang, Yao‐Ting</creator><creator>Juang, Jyh‐Ming Jimmy</creator><creator>Chiang, Fu‐Tien</creator><creator>Teng, Ming‐Sheng</creator><creator>Wu, Semon</creator><creator>Lin, Jeng‐Feng</creator><creator>Ko, Yu‐Lin</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8218-6827</orcidid></search><sort><creationdate>202107</creationdate><title>Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease</title><author>Yeh, Kuan‐Hung ; Chang, Yao‐Ting ; Juang, Jyh‐Ming Jimmy ; Chiang, Fu‐Tien ; Teng, Ming‐Sheng ; Wu, Semon ; Lin, Jeng‐Feng ; Ko, Yu‐Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3160-5aeb7d9afd7061a6ef153bfe5cb0b127112884b7c26f9fcff26d4f38e64e03b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Cerebral infarction</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary vessels</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Fibrosis</topic><topic>Growth Differentiation Factor 15</topic><topic>Heart Failure</topic><topic>Humans</topic><topic>Mortality</topic><topic>Myocardial Infarction</topic><topic>Prognosis</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Kuan‐Hung</creatorcontrib><creatorcontrib>Chang, Yao‐Ting</creatorcontrib><creatorcontrib>Juang, Jyh‐Ming Jimmy</creatorcontrib><creatorcontrib>Chiang, Fu‐Tien</creatorcontrib><creatorcontrib>Teng, Ming‐Sheng</creatorcontrib><creatorcontrib>Wu, Semon</creatorcontrib><creatorcontrib>Lin, Jeng‐Feng</creatorcontrib><creatorcontrib>Ko, Yu‐Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Kuan‐Hung</au><au>Chang, Yao‐Ting</au><au>Juang, Jyh‐Ming Jimmy</au><au>Chiang, Fu‐Tien</au><au>Teng, Ming‐Sheng</au><au>Wu, Semon</au><au>Lin, Jeng‐Feng</au><au>Ko, Yu‐Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-07</date><risdate>2021</risdate><volume>75</volume><issue>7</issue><spage>e14180</spage><epage>n/a</epage><pages>e14180-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background
The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor‐15 (GDF‐15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.
Subjects and methods
This study included 487 patients with angiographically confirmed CAD. QTc was calculated using the Bazett formula. Multiple biochemistries and GDF‐15 levels were measured. The primary endpoint was total mortality, and the secondary endpoints comprised the combination of total mortality, myocardial infarction and hospitalisation for heart failure and stroke.
Results
The mean follow‐up period was 1029 ± 343 days (5‐1692 days), during which 21 patients died and 47 had secondary endpoints. ROC curve analysis for the optimal cut‐off value of primary endpoint is 1.12 ng/mL for GDF‐15 (AUC = 0.787, P = 9.0 × 10−6) and 438.5 msec for QTc (AUC = 0.698, P = .002). Utilising linear regression, QTc has a positive correlation with Log‐GDF‐15 (r = .216, P = 1.0 × 10−6). Utilising Kaplan‐Meier analysis, both QTc interval and GDF‐15 level are significant predictors for primary end point (P = .000194, P = 2.0 × 10−6, respectively) and secondary endpoint (P = .00028, P = 6.15 × 10−8, respectively). When combined these two parameters together, a significant synergistic predictive power was noted for primary and secondary endpoint (P = 2.31 × 10−7, P = 1.26 × 10−8, respectively). This combined strategy also showed significant correlation with the severity of CAD (P < .001).
Conclusion
In Chinese patient with angiographically confirmed CAD, a combined strategy utilising an ECG parameter (QTc) and a circulating biomarker (GDF‐15) has good correlation with the severity of CAD, and improves the predictive power for total mortality.</abstract><cop>India</cop><pub>Hindawi Limited</pub><pmid>33759309</pmid><doi>10.1111/ijcp.14180</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8218-6827</orcidid></addata></record> |
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| identifier | ISSN: 1368-5031 |
| ispartof | International journal of clinical practice (Esher), 2021-07, Vol.75 (7), p.e14180-n/a |
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| source | MEDLINE; Wiley Blackwell Journals |
| subjects | Biomarkers Cardiovascular disease Cerebral infarction Congestive heart failure Coronary artery Coronary Artery Disease - diagnostic imaging Coronary vessels EKG Electrocardiography Fibrosis Growth Differentiation Factor 15 Heart Failure Humans Mortality Myocardial Infarction Prognosis Ventricle |
| title | Combined corrected QT interval and growth differentiation factor‐15 level has synergistic predictive value for long‐term outcome of angiographically confirmed coronary artery disease |
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