Development of anti-acanthamoebic approaches
Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact...
Gespeichert in:
| Veröffentlicht in: | International microbiology 2021-08, Vol.24 (3), p.363-371 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 371 |
|---|---|
| container_issue | 3 |
| container_start_page | 363 |
| container_title | International microbiology |
| container_volume | 24 |
| creator | Mungroo, Mohammad Ridwane Tong, Tommy Khan, Naveed Ahmed Anuar, Tengku Shahrul Maciver, Sutherland K. Siddiqui, Ruqaiyyah |
| description | Acanthamoeba
keratitis is a sight-endangering eye infection, and causative organism
Acanthamoeba
presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate
Acanthamoeba
effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.
Graphical abstract |
| doi_str_mv | 10.1007/s10123-021-00171-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2504351986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2504351986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a8b962566f9cc07caec2bab60d089d9ec2023b7991c91ba04ab6978dc2bc4213</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxhQJRYGDHd2YscjKp9SJZbuluM4NFW-iBMk_n1dUkBiYDpb99x7p4eQc4QbBJC3HgEZp8CQAqBEyg_IFAUmFBXEh-GNXFEhQU3IifebHSQSOCYTzmUcMY5Tcn3vPlzZtJWr-3mTz03dF9TYUNamalxa2Llp264xdu38KTnKTend2b7OyOrxYbV4psvXp5fF3ZLakNtTk6RKsFiIXFkL0hpnWWpSARkkKlPhB4ynUim0ClMDUegpmWSBshFDPiNXY2zY-z443-uq8NaVpaldM3jNYoh4jCoRAb38g26aoavDcYFK4kgqkDxQbKRs13jfuVy3XVGZ7lMj6J1KParUQaX-Uql3Qxf76CGtXPYz8u0uAHwEfGjVb6773f1P7Bbd6Hzm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2585479073</pqid></control><display><type>article</type><title>Development of anti-acanthamoebic approaches</title><source>SpringerLink Journals</source><creator>Mungroo, Mohammad Ridwane ; Tong, Tommy ; Khan, Naveed Ahmed ; Anuar, Tengku Shahrul ; Maciver, Sutherland K. ; Siddiqui, Ruqaiyyah</creator><creatorcontrib>Mungroo, Mohammad Ridwane ; Tong, Tommy ; Khan, Naveed Ahmed ; Anuar, Tengku Shahrul ; Maciver, Sutherland K. ; Siddiqui, Ruqaiyyah</creatorcontrib><description>Acanthamoeba
keratitis is a sight-endangering eye infection, and causative organism
Acanthamoeba
presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate
Acanthamoeba
effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.
Graphical abstract</description><identifier>ISSN: 1139-6709</identifier><identifier>EISSN: 1618-1905</identifier><identifier>DOI: 10.1007/s10123-021-00171-3</identifier><identifier>PMID: 33754231</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acanthamoeba ; Acarbose ; Applied Microbiology ; Bioassays ; Biomedical and Life Sciences ; Cellulose ; Conjugation ; Contact lenses ; Disinfectants ; Eukaryotic Microbiology ; Inositol ; Ion channels ; Keratitis ; Life Sciences ; Medical Microbiology ; Microbial Ecology ; Microbiology ; Nanoparticles ; Original Article ; Public health ; Toxicity</subject><ispartof>International microbiology, 2021-08, Vol.24 (3), p.363-371</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021</rights><rights>Copyright Spanish Society for Microbiology Aug 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a8b962566f9cc07caec2bab60d089d9ec2023b7991c91ba04ab6978dc2bc4213</citedby><cites>FETCH-LOGICAL-c375t-a8b962566f9cc07caec2bab60d089d9ec2023b7991c91ba04ab6978dc2bc4213</cites><orcidid>0000-0001-7667-8553</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10123-021-00171-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10123-021-00171-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33754231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mungroo, Mohammad Ridwane</creatorcontrib><creatorcontrib>Tong, Tommy</creatorcontrib><creatorcontrib>Khan, Naveed Ahmed</creatorcontrib><creatorcontrib>Anuar, Tengku Shahrul</creatorcontrib><creatorcontrib>Maciver, Sutherland K.</creatorcontrib><creatorcontrib>Siddiqui, Ruqaiyyah</creatorcontrib><title>Development of anti-acanthamoebic approaches</title><title>International microbiology</title><addtitle>Int Microbiol</addtitle><addtitle>Int Microbiol</addtitle><description>Acanthamoeba
keratitis is a sight-endangering eye infection, and causative organism
Acanthamoeba
presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate
Acanthamoeba
effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.
Graphical abstract</description><subject>Acanthamoeba</subject><subject>Acarbose</subject><subject>Applied Microbiology</subject><subject>Bioassays</subject><subject>Biomedical and Life Sciences</subject><subject>Cellulose</subject><subject>Conjugation</subject><subject>Contact lenses</subject><subject>Disinfectants</subject><subject>Eukaryotic Microbiology</subject><subject>Inositol</subject><subject>Ion channels</subject><subject>Keratitis</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Nanoparticles</subject><subject>Original Article</subject><subject>Public health</subject><subject>Toxicity</subject><issn>1139-6709</issn><issn>1618-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJRYGDHd2YscjKp9SJZbuluM4NFW-iBMk_n1dUkBiYDpb99x7p4eQc4QbBJC3HgEZp8CQAqBEyg_IFAUmFBXEh-GNXFEhQU3IifebHSQSOCYTzmUcMY5Tcn3vPlzZtJWr-3mTz03dF9TYUNamalxa2Llp264xdu38KTnKTend2b7OyOrxYbV4psvXp5fF3ZLakNtTk6RKsFiIXFkL0hpnWWpSARkkKlPhB4ynUim0ClMDUegpmWSBshFDPiNXY2zY-z443-uq8NaVpaldM3jNYoh4jCoRAb38g26aoavDcYFK4kgqkDxQbKRs13jfuVy3XVGZ7lMj6J1KParUQaX-Uql3Qxf76CGtXPYz8u0uAHwEfGjVb6773f1P7Bbd6Hzm</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Mungroo, Mohammad Ridwane</creator><creator>Tong, Tommy</creator><creator>Khan, Naveed Ahmed</creator><creator>Anuar, Tengku Shahrul</creator><creator>Maciver, Sutherland K.</creator><creator>Siddiqui, Ruqaiyyah</creator><general>Springer International Publishing</general><general>Spanish Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7667-8553</orcidid></search><sort><creationdate>20210801</creationdate><title>Development of anti-acanthamoebic approaches</title><author>Mungroo, Mohammad Ridwane ; Tong, Tommy ; Khan, Naveed Ahmed ; Anuar, Tengku Shahrul ; Maciver, Sutherland K. ; Siddiqui, Ruqaiyyah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a8b962566f9cc07caec2bab60d089d9ec2023b7991c91ba04ab6978dc2bc4213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acanthamoeba</topic><topic>Acarbose</topic><topic>Applied Microbiology</topic><topic>Bioassays</topic><topic>Biomedical and Life Sciences</topic><topic>Cellulose</topic><topic>Conjugation</topic><topic>Contact lenses</topic><topic>Disinfectants</topic><topic>Eukaryotic Microbiology</topic><topic>Inositol</topic><topic>Ion channels</topic><topic>Keratitis</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Nanoparticles</topic><topic>Original Article</topic><topic>Public health</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mungroo, Mohammad Ridwane</creatorcontrib><creatorcontrib>Tong, Tommy</creatorcontrib><creatorcontrib>Khan, Naveed Ahmed</creatorcontrib><creatorcontrib>Anuar, Tengku Shahrul</creatorcontrib><creatorcontrib>Maciver, Sutherland K.</creatorcontrib><creatorcontrib>Siddiqui, Ruqaiyyah</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>International microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mungroo, Mohammad Ridwane</au><au>Tong, Tommy</au><au>Khan, Naveed Ahmed</au><au>Anuar, Tengku Shahrul</au><au>Maciver, Sutherland K.</au><au>Siddiqui, Ruqaiyyah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of anti-acanthamoebic approaches</atitle><jtitle>International microbiology</jtitle><stitle>Int Microbiol</stitle><addtitle>Int Microbiol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>24</volume><issue>3</issue><spage>363</spage><epage>371</epage><pages>363-371</pages><issn>1139-6709</issn><eissn>1618-1905</eissn><abstract>Acanthamoeba
keratitis is a sight-endangering eye infection, and causative organism
Acanthamoeba
presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate
Acanthamoeba
effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.
Graphical abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33754231</pmid><doi>10.1007/s10123-021-00171-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7667-8553</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1139-6709 |
| ispartof | International microbiology, 2021-08, Vol.24 (3), p.363-371 |
| issn | 1139-6709 1618-1905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2504351986 |
| source | SpringerLink Journals |
| subjects | Acanthamoeba Acarbose Applied Microbiology Bioassays Biomedical and Life Sciences Cellulose Conjugation Contact lenses Disinfectants Eukaryotic Microbiology Inositol Ion channels Keratitis Life Sciences Medical Microbiology Microbial Ecology Microbiology Nanoparticles Original Article Public health Toxicity |
| title | Development of anti-acanthamoebic approaches |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A33%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20anti-acanthamoebic%20approaches&rft.jtitle=International%20microbiology&rft.au=Mungroo,%20Mohammad%20Ridwane&rft.date=2021-08-01&rft.volume=24&rft.issue=3&rft.spage=363&rft.epage=371&rft.pages=363-371&rft.issn=1139-6709&rft.eissn=1618-1905&rft_id=info:doi/10.1007/s10123-021-00171-3&rft_dat=%3Cproquest_cross%3E2504351986%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2585479073&rft_id=info:pmid/33754231&rfr_iscdi=true |