Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma

High-grade serous ovarian cancer (HGSOC) is characterized by chromosomal instability, DNA damage, oxidative stress, and high metabolic demand that exacerbate misfolded, unfolded, and damaged protein burden resulting in increased proteotoxicity. However, the underlying mechanisms that maintain protei...

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Veröffentlicht in:	Molecular cancer research 2021-07, Vol.19 (7), p.1168-1181
Hauptverfasser:	Tangri, Apoorva, Lighty, Kinzie, Loganathan, Jagadish, Mesmar, Fahmi, Podicheti, Ram, Zhang, Chi, Iwanicki, Marcin, Drapkin, Ronny, Nakshatri, Harikrishna, Mitra, Sumegha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - metabolism Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Indoles - pharmacology Kaplan-Meier Estimate Mice Mice, Nude Neoplasm Grading Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Oximes - pharmacology Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteostasis - genetics Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Xenograft Model Antitumor Assays - methods
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