Role of pyroptosis in atherosclerosis and its therapeutic implications
Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflamma...
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| Veröffentlicht in: | Journal of cellular physiology 2021-10, Vol.236 (10), p.7159-7175 |
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| container_issue | 10 |
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| container_title | Journal of cellular physiology |
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| creator | He, Bin Nie, Qiangqiang Wang, Feng Han, Yongxin Yang, Bo Sun, Mingsheng Fan, Xueqiang Ye, Zhidong Liu, Peng Wen, Jianyan |
| description | Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.
Graphical
Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis. |
| doi_str_mv | 10.1002/jcp.30366 |
| format | Article |
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Graphical
Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30366</identifier><identifier>PMID: 33755211</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>anti‐inflammatory treatment ; Arteriosclerosis ; Atherosclerosis ; caspase‐1 ; Cell death ; Cell size ; Chemical compounds ; Cytokines ; GSDMD ; inflammation ; Inflammatory diseases ; Interleukins ; NLRP3 ; Pharmacology ; Pyroptosis</subject><ispartof>Journal of cellular physiology, 2021-10, Vol.236 (10), p.7159-7175</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-e5895452585294062d59337595225c83cdbe5c6db933a54adba3c72501038e0b3</citedby><cites>FETCH-LOGICAL-c3536-e5895452585294062d59337595225c83cdbe5c6db933a54adba3c72501038e0b3</cites><orcidid>0000-0002-1506-8206 ; 0000-0001-5762-6504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.30366$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.30366$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33755211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Bin</creatorcontrib><creatorcontrib>Nie, Qiangqiang</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Han, Yongxin</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Sun, Mingsheng</creatorcontrib><creatorcontrib>Fan, Xueqiang</creatorcontrib><creatorcontrib>Ye, Zhidong</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Wen, Jianyan</creatorcontrib><title>Role of pyroptosis in atherosclerosis and its therapeutic implications</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.
Graphical
Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.</description><subject>anti‐inflammatory treatment</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>caspase‐1</subject><subject>Cell death</subject><subject>Cell size</subject><subject>Chemical compounds</subject><subject>Cytokines</subject><subject>GSDMD</subject><subject>inflammation</subject><subject>Inflammatory diseases</subject><subject>Interleukins</subject><subject>NLRP3</subject><subject>Pharmacology</subject><subject>Pyroptosis</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLw0AUhQdRbK0u_AMScKOLtPO6k2QpxfqgoIiuh8lkilOSTMwkSP-9E1NdCG7uhXM_DucehM4JnhOM6WKrmznDTIgDNCU4S2IugB6iabiROANOJujE-y3GOMsYO0YTxhIASsgUrV5caSK3iZpd65rOeesjW0eqezet87ocZpBUXUS289Egq8b0ndWRrZrSatVZV_tTdLRRpTdn-z1Db6vb1-V9vH66e1jerGPNgInYQBriAIUUaMaxoAVkQ5YMKAWdMl3kBrQo8qAq4KrIFdMJBUwwSw3O2Qxdjb5N6z564ztZWa9NWarauN7LgHLGKRUsoJd_0K3r2zqkC5TgPLzPk0Bdj5QOj_rWbGTT2kq1O0mwHMqVoVz5XW5gL_aOfV6Z4pf8aTMAixH4tKXZ_e8kH5fPo-UXQCKBbw</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>He, Bin</creator><creator>Nie, Qiangqiang</creator><creator>Wang, Feng</creator><creator>Han, Yongxin</creator><creator>Yang, Bo</creator><creator>Sun, Mingsheng</creator><creator>Fan, Xueqiang</creator><creator>Ye, Zhidong</creator><creator>Liu, Peng</creator><creator>Wen, Jianyan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1506-8206</orcidid><orcidid>https://orcid.org/0000-0001-5762-6504</orcidid></search><sort><creationdate>202110</creationdate><title>Role of pyroptosis in atherosclerosis and its therapeutic implications</title><author>He, Bin ; Nie, Qiangqiang ; Wang, Feng ; Han, Yongxin ; Yang, Bo ; Sun, Mingsheng ; Fan, Xueqiang ; Ye, Zhidong ; Liu, Peng ; Wen, Jianyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-e5895452585294062d59337595225c83cdbe5c6db933a54adba3c72501038e0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>anti‐inflammatory treatment</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>caspase‐1</topic><topic>Cell death</topic><topic>Cell size</topic><topic>Chemical compounds</topic><topic>Cytokines</topic><topic>GSDMD</topic><topic>inflammation</topic><topic>Inflammatory diseases</topic><topic>Interleukins</topic><topic>NLRP3</topic><topic>Pharmacology</topic><topic>Pyroptosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Bin</creatorcontrib><creatorcontrib>Nie, Qiangqiang</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Han, Yongxin</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Sun, Mingsheng</creatorcontrib><creatorcontrib>Fan, Xueqiang</creatorcontrib><creatorcontrib>Ye, Zhidong</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Wen, Jianyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Bin</au><au>Nie, Qiangqiang</au><au>Wang, Feng</au><au>Han, Yongxin</au><au>Yang, Bo</au><au>Sun, Mingsheng</au><au>Fan, Xueqiang</au><au>Ye, Zhidong</au><au>Liu, Peng</au><au>Wen, Jianyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of pyroptosis in atherosclerosis and its therapeutic implications</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>236</volume><issue>10</issue><spage>7159</spage><epage>7175</epage><pages>7159-7175</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.
Graphical
Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33755211</pmid><doi>10.1002/jcp.30366</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-1506-8206</orcidid><orcidid>https://orcid.org/0000-0001-5762-6504</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | anti‐inflammatory treatment Arteriosclerosis Atherosclerosis caspase‐1 Cell death Cell size Chemical compounds Cytokines GSDMD inflammation Inflammatory diseases Interleukins NLRP3 Pharmacology Pyroptosis |
| title | Role of pyroptosis in atherosclerosis and its therapeutic implications |
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