circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway
Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this stud...
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| Veröffentlicht in: | Journal of cellular physiology 2021-10, Vol.236 (10), p.6793-6805 |
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| creator | Gao, Mengjin Li, Xue Yang, Zuojun Zhao, Shuo Ling, Xingxing Li, Jingjing Xing, Kai Qi, Xiaolong Wang, Xiangguo Xiao, Longfei Ni, Hemin Guo, Yong Sheng, Xihui |
| description | Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR‐7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.
miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. |
| doi_str_mv | 10.1002/jcp.30363 |
| format | Article |
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miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30363</identifier><identifier>PMID: 33748999</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biological activity ; Cell differentiation ; Cell growth ; Cell proliferation ; circHIPK3 ; Differentiation ; miRNA ; miR‐7 ; Muscles ; Musculoskeletal system ; myoblast proliferation and differentiation ; Myoblasts ; Skeletal muscle ; skeletal muscle development ; TCF12</subject><ispartof>Journal of cellular physiology, 2021-10, Vol.236 (10), p.6793-6805</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-15769d5e3a44407294c8ef953447342ce731f875049d6d1755d9551e80714d223</citedby><cites>FETCH-LOGICAL-c3533-15769d5e3a44407294c8ef953447342ce731f875049d6d1755d9551e80714d223</cites><orcidid>0000-0002-5001-7930 ; 0000-0002-2513-2021 ; 0000-0001-5790-6645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.30363$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.30363$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33748999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Mengjin</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><creatorcontrib>Yang, Zuojun</creatorcontrib><creatorcontrib>Zhao, Shuo</creatorcontrib><creatorcontrib>Ling, Xingxing</creatorcontrib><creatorcontrib>Li, Jingjing</creatorcontrib><creatorcontrib>Xing, Kai</creatorcontrib><creatorcontrib>Qi, Xiaolong</creatorcontrib><creatorcontrib>Wang, Xiangguo</creatorcontrib><creatorcontrib>Xiao, Longfei</creatorcontrib><creatorcontrib>Ni, Hemin</creatorcontrib><creatorcontrib>Guo, Yong</creatorcontrib><creatorcontrib>Sheng, Xihui</creatorcontrib><title>circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR‐7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.
miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression.</description><subject>Biological activity</subject><subject>Cell differentiation</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>circHIPK3</subject><subject>Differentiation</subject><subject>miRNA</subject><subject>miR‐7</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>myoblast proliferation and differentiation</subject><subject>Myoblasts</subject><subject>Skeletal muscle</subject><subject>skeletal muscle development</subject><subject>TCF12</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUQIMoWqsLf0AG3OhibJKbTJqlFB9VwSJ1PaSZTJsyj5rMULrzE_xGv8ToVBeCq0tyD4fLQeiE4EuCMR0s9eoSMCSwg3oESxGzhNNd1As7EkvOyAE69H6JMZYSYB8dAAg2lFL2kNbW6bvx5AEiZ-ZtoRrjo5WrC5sbpxpbV5GqsiizeXibqrHdX51H5aaeFco3UbNwdTtfhGmi0j5_vL2LwXR0Q2i0Us1irTZHaC9XhTfH29lHLzfX09Fd_Ph0Ox5dPcYaOEBMuEhkxg0oxhgWVDI9NLnkwJgARrURQPKh4JjJLMmI4DyTnBMzxIKwjFLoo_POG-5_bY1v0tJ6bYpCVaZufUp5aCQoC8o-OvuDLuvWVeG6QCWMUQJcBuqio7SrvXcmT1fOlsptUoLTr_JpKJ9-lw_s6dbYzkqT_ZI_qQMw6IC1Lczmf1N6P5p0yk9IVosi</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Gao, Mengjin</creator><creator>Li, Xue</creator><creator>Yang, Zuojun</creator><creator>Zhao, Shuo</creator><creator>Ling, Xingxing</creator><creator>Li, Jingjing</creator><creator>Xing, Kai</creator><creator>Qi, Xiaolong</creator><creator>Wang, Xiangguo</creator><creator>Xiao, Longfei</creator><creator>Ni, Hemin</creator><creator>Guo, Yong</creator><creator>Sheng, Xihui</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5001-7930</orcidid><orcidid>https://orcid.org/0000-0002-2513-2021</orcidid><orcidid>https://orcid.org/0000-0001-5790-6645</orcidid></search><sort><creationdate>202110</creationdate><title>circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway</title><author>Gao, Mengjin ; Li, Xue ; Yang, Zuojun ; Zhao, Shuo ; Ling, Xingxing ; Li, Jingjing ; Xing, Kai ; Qi, Xiaolong ; Wang, Xiangguo ; Xiao, Longfei ; Ni, Hemin ; Guo, Yong ; Sheng, Xihui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-15769d5e3a44407294c8ef953447342ce731f875049d6d1755d9551e80714d223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biological activity</topic><topic>Cell differentiation</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>circHIPK3</topic><topic>Differentiation</topic><topic>miRNA</topic><topic>miR‐7</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>myoblast proliferation and differentiation</topic><topic>Myoblasts</topic><topic>Skeletal muscle</topic><topic>skeletal muscle development</topic><topic>TCF12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Mengjin</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><creatorcontrib>Yang, Zuojun</creatorcontrib><creatorcontrib>Zhao, Shuo</creatorcontrib><creatorcontrib>Ling, Xingxing</creatorcontrib><creatorcontrib>Li, Jingjing</creatorcontrib><creatorcontrib>Xing, Kai</creatorcontrib><creatorcontrib>Qi, Xiaolong</creatorcontrib><creatorcontrib>Wang, Xiangguo</creatorcontrib><creatorcontrib>Xiao, Longfei</creatorcontrib><creatorcontrib>Ni, Hemin</creatorcontrib><creatorcontrib>Guo, Yong</creatorcontrib><creatorcontrib>Sheng, Xihui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Mengjin</au><au>Li, Xue</au><au>Yang, Zuojun</au><au>Zhao, Shuo</au><au>Ling, Xingxing</au><au>Li, Jingjing</au><au>Xing, Kai</au><au>Qi, Xiaolong</au><au>Wang, Xiangguo</au><au>Xiao, Longfei</au><au>Ni, Hemin</au><au>Guo, Yong</au><au>Sheng, Xihui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>236</volume><issue>10</issue><spage>6793</spage><epage>6805</epage><pages>6793-6805</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR‐7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.
miR‐7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR‐7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33748999</pmid><doi>10.1002/jcp.30363</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5001-7930</orcidid><orcidid>https://orcid.org/0000-0002-2513-2021</orcidid><orcidid>https://orcid.org/0000-0001-5790-6645</orcidid></addata></record> |
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| subjects | Biological activity Cell differentiation Cell growth Cell proliferation circHIPK3 Differentiation miRNA miR‐7 Muscles Musculoskeletal system myoblast proliferation and differentiation Myoblasts Skeletal muscle skeletal muscle development TCF12 |
| title | circHIPK3 regulates proliferation and differentiation of myoblast through the miR‐7/TCF12 pathway |
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