Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis

Background. Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and anti-inflammatory activity. G. lucidum seeds inherit all its biological characteristics. G. lucidum spore polysaccharide (GLSP) is the main active ingredient to enhance these...

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Veröffentlicht in:	Journal of Immunology Research 2021-03, Vol.2021, p.6696606-14, Article 6696606
Hauptverfasser:	Song, Ming, Li, Zhen-hao, Gu, Hong-shun, Tang, Ru-ying, Zhang, Rui, Zhu, Ying-li, Liu, Jin-lian, Zhang, Jian-jun, Wang, Lin-yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Animals Anti-inflammatory agents Apoptosis BAX protein Bcl-2 protein Cancer therapies Carcinoma, Hepatocellular - therapy Caspase-9 Cell cycle Cell Differentiation Cell proliferation Cells, Cultured Chemokines Chemotherapy Chinese medicine Cytokines Cytokines - metabolism Cytotoxicity Drugs Flow cytometry Fungal Polysaccharides - metabolism Ganoderma lucidum Growth Growth factors Hepatocellular carcinoma Hepatoma Homeostasis IL-1β Immunology Inflammation Interleukin 6 Life Sciences & Biomedicine Liver cancer Liver Neoplasms - therapy Macrophage Activation Macrophages Macrophages - immunology Medical prognosis Mice Mice, Inbred BALB C Microorganisms Mitochondria Phosphatidylinositol 3-Kinases - metabolism Phytotherapy - trends Polarity Polarization Polysaccharides Reishi - immunology Science & Technology Scientific equipment and supplies industry Seeds Signal Transduction Spores, Fungal Th1 Cells - immunology Transforming growth factor-b1 Tumor cells Tumor microenvironment Tumor necrosis factor-α Tumors Western blotting
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