Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame

•A highly conserved short open reading frame (sORF) is present in exon 2 upstream of the angiotensin (Ang II) 1a receptor (AT1aR) coding region.•This sORF has no effect on rate of AT1aR internalization.•This sORF decreases ligand potency for Ang II activation of extracellular signal-related kinases...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2021-06, Vol.140, p.170529-170529, Article 170529
Hauptverfasser:	Kadam, Parnika S., Mueller, Susette C., Ji, Hong, Liu, Jun, Pai, Amrita V., Ma, Junfeng, Speth, Robert C., Sandberg, Kathryn
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Angiotensin II - pharmacology Animals Biased agonist Blood Pressure - physiology Cell Line Cell Survival - physiology Endocytosis Humans MAP Kinase Signaling System - drug effects Open Reading Frames - genetics PEP7 Phosphorylation Posttranscriptional regulation Rats Receptor internalization Receptor, Angiotensin, Type 1 - chemistry Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Signal Transduction Transfection - methods β-arrestin
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