Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler
•An experimental self-adhesive resin for direct pulp capping (SRD) was developed.•SRDs consisted of various monomers, silica, and S-PRG fillers of various contents.•The SRD containing silica filler without S-PRG filler formed orthodentin.•The SRDs containing high content of S-PRG filler formed ectop...
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| Veröffentlicht in: | Dental materials 2021-06, Vol.37 (6), p.972-982 |
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| creator | Sato, Fumiaki Suzuki, Masaya Shinkai, Koichi |
| description | •An experimental self-adhesive resin for direct pulp capping (SRD) was developed.•SRDs consisted of various monomers, silica, and S-PRG fillers of various contents.•The SRD containing silica filler without S-PRG filler formed orthodentin.•The SRDs containing high content of S-PRG filler formed ectopic osteodentin.•SRD may have the potential to be utilized clinically direct pulp capping material.
This study aimed to evaluate the effect of direct pulp capping using an experimental self-adhesive resin for direct pulp capping (SRD) containing silica and surface pre-reacted glass-ionomer (S-PRG) filler on pulpal healing and to monitor the dentin bridge formation in rat pulp 2–4 weeks after operation.
Five types of SRDs (SRD-0: S-PRG fillers 0 wt%; SRD-1: S-PRG fillers 9.1 wt%; SRD-2: S-PRG fillers 18.4 wt%; SRD-3: S-PRG fillers 27.8 wt%; and SRD-6: S-PRG fillers 57.4 wt%) were prepared, and mineral trioxide aggregate (MTA) was used as control (n = 8). Direct pulp capping was performed on rats that were sacrificed for further evaluation 2 or 4 weeks after the operation. The pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), and reparative dentin formation were histopathologically evaluated; the data were statistically analyzed using the Kruskal–Wallis and the Mann–Whitney U tests.
The histopathological evaluation of SRD-1-treated test animals 2 weeks post-operation revealed inferior PTD and ICI when compared with that of MTA. Even 4 weeks after the operation in SRD-1- and SRD-2-treated rats, the PTD and ICI were inferior when compared with those of MTA. The dental specimens of SRD-0 and MTA showed orthodentin formation, whereas SRD-treated test animals showed osteodentin formation at a position slightly deeper than the site of the pulpal exposure.
The reparative dentin formed by SRD-0 and MTA was genuine, whereas that formed by SRD-3 and SRD-6 was ossified and ectopic. SRD may have the potential to be utilized clinically as a direct pulp capping material. |
| doi_str_mv | 10.1016/j.dental.2021.02.014 |
| format | Article |
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This study aimed to evaluate the effect of direct pulp capping using an experimental self-adhesive resin for direct pulp capping (SRD) containing silica and surface pre-reacted glass-ionomer (S-PRG) filler on pulpal healing and to monitor the dentin bridge formation in rat pulp 2–4 weeks after operation.
Five types of SRDs (SRD-0: S-PRG fillers 0 wt%; SRD-1: S-PRG fillers 9.1 wt%; SRD-2: S-PRG fillers 18.4 wt%; SRD-3: S-PRG fillers 27.8 wt%; and SRD-6: S-PRG fillers 57.4 wt%) were prepared, and mineral trioxide aggregate (MTA) was used as control (n = 8). Direct pulp capping was performed on rats that were sacrificed for further evaluation 2 or 4 weeks after the operation. The pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), and reparative dentin formation were histopathologically evaluated; the data were statistically analyzed using the Kruskal–Wallis and the Mann–Whitney U tests.
The histopathological evaluation of SRD-1-treated test animals 2 weeks post-operation revealed inferior PTD and ICI when compared with that of MTA. Even 4 weeks after the operation in SRD-1- and SRD-2-treated rats, the PTD and ICI were inferior when compared with those of MTA. The dental specimens of SRD-0 and MTA showed orthodentin formation, whereas SRD-treated test animals showed osteodentin formation at a position slightly deeper than the site of the pulpal exposure.
The reparative dentin formed by SRD-0 and MTA was genuine, whereas that formed by SRD-3 and SRD-6 was ossified and ectopic. SRD may have the potential to be utilized clinically as a direct pulp capping material.</description><identifier>ISSN: 0109-5641</identifier><identifier>EISSN: 1879-0097</identifier><identifier>DOI: 10.1016/j.dental.2021.02.014</identifier><identifier>PMID: 33744000</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adhesives ; Animals ; Biomedical materials ; Capping ; Dental cement ; Dental materials ; Dental pulp ; Dentin ; Dentistry ; Direct pulp capping ; Filler contents ; Fillers ; Inflammation ; Ionomers ; Multi-ion release ; Resins ; Rodents ; Self-adhesive resin ; Silica ; Silicon dioxide ; Surface pre-reacted glass-ionomer filler ; Test animals</subject><ispartof>Dental materials, 2021-06, Vol.37 (6), p.972-982</ispartof><rights>2021 The Academy of Dental Materials</rights><rights>Copyright © 2021 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Jun 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-5cd740b74d258e7ab0078789539f62b294f5e393b8e18a72c342d8725eb269193</citedby><cites>FETCH-LOGICAL-c456t-5cd740b74d258e7ab0078789539f62b294f5e393b8e18a72c342d8725eb269193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dental.2021.02.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33744000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Fumiaki</creatorcontrib><creatorcontrib>Suzuki, Masaya</creatorcontrib><creatorcontrib>Shinkai, Koichi</creatorcontrib><title>Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler</title><title>Dental materials</title><addtitle>Dent Mater</addtitle><description>•An experimental self-adhesive resin for direct pulp capping (SRD) was developed.•SRDs consisted of various monomers, silica, and S-PRG fillers of various contents.•The SRD containing silica filler without S-PRG filler formed orthodentin.•The SRDs containing high content of S-PRG filler formed ectopic osteodentin.•SRD may have the potential to be utilized clinically direct pulp capping material.
This study aimed to evaluate the effect of direct pulp capping using an experimental self-adhesive resin for direct pulp capping (SRD) containing silica and surface pre-reacted glass-ionomer (S-PRG) filler on pulpal healing and to monitor the dentin bridge formation in rat pulp 2–4 weeks after operation.
Five types of SRDs (SRD-0: S-PRG fillers 0 wt%; SRD-1: S-PRG fillers 9.1 wt%; SRD-2: S-PRG fillers 18.4 wt%; SRD-3: S-PRG fillers 27.8 wt%; and SRD-6: S-PRG fillers 57.4 wt%) were prepared, and mineral trioxide aggregate (MTA) was used as control (n = 8). Direct pulp capping was performed on rats that were sacrificed for further evaluation 2 or 4 weeks after the operation. The pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), and reparative dentin formation were histopathologically evaluated; the data were statistically analyzed using the Kruskal–Wallis and the Mann–Whitney U tests.
The histopathological evaluation of SRD-1-treated test animals 2 weeks post-operation revealed inferior PTD and ICI when compared with that of MTA. Even 4 weeks after the operation in SRD-1- and SRD-2-treated rats, the PTD and ICI were inferior when compared with those of MTA. The dental specimens of SRD-0 and MTA showed orthodentin formation, whereas SRD-treated test animals showed osteodentin formation at a position slightly deeper than the site of the pulpal exposure.
The reparative dentin formed by SRD-0 and MTA was genuine, whereas that formed by SRD-3 and SRD-6 was ossified and ectopic. SRD may have the potential to be utilized clinically as a direct pulp capping material.</description><subject>Adhesives</subject><subject>Animals</subject><subject>Biomedical materials</subject><subject>Capping</subject><subject>Dental cement</subject><subject>Dental materials</subject><subject>Dental pulp</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Direct pulp capping</subject><subject>Filler contents</subject><subject>Fillers</subject><subject>Inflammation</subject><subject>Ionomers</subject><subject>Multi-ion release</subject><subject>Resins</subject><subject>Rodents</subject><subject>Self-adhesive resin</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Surface pre-reacted glass-ionomer filler</subject><subject>Test animals</subject><issn>0109-5641</issn><issn>1879-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcuKFTEQhoM4OMfRNxAJuJmFaXPtdDaCDOMFBnSh65BOqscc0heT7gEfwPeeHHt04cJVqNT3_1XUj9ALRhtGWfvm2ASYVpcaTjlrKG8ok4_QgXXaEEqNfowOlFFDVCvZOXpaypFSKrlhT9C5EFrKWh7Qry9bWvAaS9kAZ3B-jfOE1xk7XCANxIXvUOIdvK7NEifSuwIBh5jBr3g5ab1bljjd4tGtkKNL2M91rTid_sqWB-cBLxnIb_OqvU2uFFKnzCNkPMSUID9DZ4NLBZ4_vBfo2_vrr1cfyc3nD5-u3t0QL1W7EuWDlrTXMnDVgXY9pbrTnVHCDC3vuZGDAmFE3wHrnOZeSB46zRX0vDXMiAt0ufsuef6xQVntGIuHlNwE81YsV1S0yuhWVvTVP-hx3vJUt6uU5FrorhWVkjvl81xKhsEuOY4u_7SM2lNM9mj3mOwpJku5rTFV2csH860fIfwV_cmlAm93AOo17iJkW3yEycN-eRvm-P8J99jwpcI</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Sato, Fumiaki</creator><creator>Suzuki, Masaya</creator><creator>Shinkai, Koichi</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler</title><author>Sato, Fumiaki ; Suzuki, Masaya ; Shinkai, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-5cd740b74d258e7ab0078789539f62b294f5e393b8e18a72c342d8725eb269193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adhesives</topic><topic>Animals</topic><topic>Biomedical materials</topic><topic>Capping</topic><topic>Dental cement</topic><topic>Dental materials</topic><topic>Dental pulp</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Direct pulp capping</topic><topic>Filler contents</topic><topic>Fillers</topic><topic>Inflammation</topic><topic>Ionomers</topic><topic>Multi-ion release</topic><topic>Resins</topic><topic>Rodents</topic><topic>Self-adhesive resin</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Surface pre-reacted glass-ionomer filler</topic><topic>Test animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Fumiaki</creatorcontrib><creatorcontrib>Suzuki, Masaya</creatorcontrib><creatorcontrib>Shinkai, Koichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Dental materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Fumiaki</au><au>Suzuki, Masaya</au><au>Shinkai, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler</atitle><jtitle>Dental materials</jtitle><addtitle>Dent Mater</addtitle><date>2021-06</date><risdate>2021</risdate><volume>37</volume><issue>6</issue><spage>972</spage><epage>982</epage><pages>972-982</pages><issn>0109-5641</issn><eissn>1879-0097</eissn><abstract>•An experimental self-adhesive resin for direct pulp capping (SRD) was developed.•SRDs consisted of various monomers, silica, and S-PRG fillers of various contents.•The SRD containing silica filler without S-PRG filler formed orthodentin.•The SRDs containing high content of S-PRG filler formed ectopic osteodentin.•SRD may have the potential to be utilized clinically direct pulp capping material.
This study aimed to evaluate the effect of direct pulp capping using an experimental self-adhesive resin for direct pulp capping (SRD) containing silica and surface pre-reacted glass-ionomer (S-PRG) filler on pulpal healing and to monitor the dentin bridge formation in rat pulp 2–4 weeks after operation.
Five types of SRDs (SRD-0: S-PRG fillers 0 wt%; SRD-1: S-PRG fillers 9.1 wt%; SRD-2: S-PRG fillers 18.4 wt%; SRD-3: S-PRG fillers 27.8 wt%; and SRD-6: S-PRG fillers 57.4 wt%) were prepared, and mineral trioxide aggregate (MTA) was used as control (n = 8). Direct pulp capping was performed on rats that were sacrificed for further evaluation 2 or 4 weeks after the operation. The pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), and reparative dentin formation were histopathologically evaluated; the data were statistically analyzed using the Kruskal–Wallis and the Mann–Whitney U tests.
The histopathological evaluation of SRD-1-treated test animals 2 weeks post-operation revealed inferior PTD and ICI when compared with that of MTA. Even 4 weeks after the operation in SRD-1- and SRD-2-treated rats, the PTD and ICI were inferior when compared with those of MTA. The dental specimens of SRD-0 and MTA showed orthodentin formation, whereas SRD-treated test animals showed osteodentin formation at a position slightly deeper than the site of the pulpal exposure.
The reparative dentin formed by SRD-0 and MTA was genuine, whereas that formed by SRD-3 and SRD-6 was ossified and ectopic. SRD may have the potential to be utilized clinically as a direct pulp capping material.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>33744000</pmid><doi>10.1016/j.dental.2021.02.014</doi><tpages>11</tpages></addata></record> |
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| ispartof | Dental materials, 2021-06, Vol.37 (6), p.972-982 |
| issn | 0109-5641 1879-0097 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Adhesives Animals Biomedical materials Capping Dental cement Dental materials Dental pulp Dentin Dentistry Direct pulp capping Filler contents Fillers Inflammation Ionomers Multi-ion release Resins Rodents Self-adhesive resin Silica Silicon dioxide Surface pre-reacted glass-ionomer filler Test animals |
| title | Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler |
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