Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial

Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously been shown to extend progression-free survival versus placebo when given to patients with relapsed high-grade serous or endometrioid ovarian cancer who were platinum sensitive and who had a BRCA1 or BRCA2 (BRCA1/2) mutation, a...

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Veröffentlicht in:	The lancet oncology 2021-05, Vol.22 (5), p.620-631
Hauptverfasser:	Poveda, Andrés, Floquet, Anne, Ledermann, Jonathan A, Penson, Richard T, Oza, Amit M, Korach, Jacob, Huzarski, Tomasz, Pignata, Sandro, Friedlander, Michael, Baldoni, Alessandra, Park-Simon, Tjoung-Won, Tamura, Kenji, Lisyanskaya, Alla, Kim, Jae-Hoon, Filho, Elias Abdo, Milenkova, Tsveta, Lowe, Elizabeth S, Rowe, Phil, Pujade-Lauraine, Eric, Byrski, Tomasz, Pautier, Patricia, Harter, Philipp, Colombo, Nicoletta, Scambia, Giovanni, Nicoletto, Maria, Nussey, Fiona, Clamp, Andrew, Penson, Richard, Rodrigues, Manuel, Lotz, Jean-Pierre, Selle, Frédéric, Ray-Coquard, Isabelle, Provencher, Diane, Prat Aparicio, Aleix, Yunokawa, Mayu, Medioni, Jacques, Pécuchet, Nicolas, Dubot, Coraline, Kaminsky, Marie-Christine, Weber, Béatrice, Parkinson, Christine, Ledermann, Jonathan, Williams, Sarah, Banerjee, Susana, Cosin, Jonathan, Hoffman, James, Plante, Marie, Covens, Allan, Sonke, Gabe, Joly, Florence, Hirte, Holger, Amit, Amnon, Matsumoto, Koji, Tjulandin, Sergei, Gladieff, Laurence, Sabbatini, Roberto, O'Malley, David, Timmins, Patrick, Kredentser, Daniel, Laínez Milagro, Nuria, Tibau Martorell, Ariadna, Gómez De Liaño Lista, Alfonso, Ojeda González, Belén, Mandai, Masaki, Boere, Ingrid, Ottevanger, Petronella, Nam, Joo-Hyun, Filho, Elias, Hamizi, Salima, Cognetti, Francesco, Warshal, David, Dickson-Michelson, Elizabeth, Kamelle, Scott, Rodriguez, Gustavo, Celano, Paul, Behbakht, Kian, Davidson, Susan, Helpman, Limor, Fishman, Ami, Bruchim, Ilan, Sikorska, Magdalena, Słowińska, Anna, Rogowski, Wojciech, Śpiewankiewicz, Beata, Casado Herraez, Antonio, Mendiola Fernández, César, Saito, Toshiaki, Takehara, Kazuhiro, Enomoto, Takayuki, Watari, Hidemichi, Choi, Chel Hun, Kim, Byoung-Gie, Weon Kim, Jae, Hegg, Roberto, Vergote, Ignace
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adverse events BRCA1 protein BRCA2 protein Cancer therapies Chemotherapy Clinical medicine Dosage Double-Blind Method Double-blind studies Fallopian tube Female Genes, BRCA1 Genes, BRCA2 Genital cancers Hepatitis Humans Leukemia Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic syndromes Neoplasm Recurrence, Local - drug therapy Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Patients Peritoneum Phthalazines - adverse effects Phthalazines - therapeutic use Piperazines - adverse effects Piperazines - therapeutic use Placebos Platinum Poly(ADP-ribose) polymerase Ribose Survival Tablets
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