Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma
Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists bet...
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| Veröffentlicht in: | World neurosurgery 2021-07, Vol.151, p.e37-e46 |
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| creator | Ge, Xinqi Jiang, Shichen Wang, Ziheng Hu, Nan Jiang, Rui Cai, Zishu Wu, Bin Zhang, Yu Gong, Peipei |
| description | Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes.
Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.
According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.
Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases. |
| doi_str_mv | 10.1016/j.wneu.2021.03.064 |
| format | Article |
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Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.
According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.
Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2021.03.064</identifier><identifier>PMID: 33746099</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Algorithms ; Biomarkers, Tumor - blood ; Brain Neoplasms - blood ; Brain Neoplasms - diagnosis ; Brain Neoplasms - immunology ; CGGA ; CIBERSORT ; Databases, Genetic ; DNA-Binding Proteins - blood ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; GEPIA ; Glioma ; Glioma - blood ; Glioma - diagnosis ; Glioma - immunology ; Humans ; Isocitrate Dehydrogenase - blood ; Male ; Middle Aged ; Prognosis ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Survival Analysis ; Tumor Microenvironment ; ZNF311</subject><ispartof>World neurosurgery, 2021-07, Vol.151, p.e37-e46</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1701b81eda94fcb5dbcdf0a31af8a9370bee459eb6111afdf4c15978a508acdc3</citedby><cites>FETCH-LOGICAL-c356t-1701b81eda94fcb5dbcdf0a31af8a9370bee459eb6111afdf4c15978a508acdc3</cites><orcidid>0000-0001-8873-732X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1878875021004344$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33746099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ge, Xinqi</creatorcontrib><creatorcontrib>Jiang, Shichen</creatorcontrib><creatorcontrib>Wang, Ziheng</creatorcontrib><creatorcontrib>Hu, Nan</creatorcontrib><creatorcontrib>Jiang, Rui</creatorcontrib><creatorcontrib>Cai, Zishu</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Gong, Peipei</creatorcontrib><title>Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes.
Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.
According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.
Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases.</description><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Biomarkers, Tumor - blood</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - immunology</subject><subject>CGGA</subject><subject>CIBERSORT</subject><subject>Databases, Genetic</subject><subject>DNA-Binding Proteins - blood</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>GEPIA</subject><subject>Glioma</subject><subject>Glioma - blood</subject><subject>Glioma - diagnosis</subject><subject>Glioma - immunology</subject><subject>Humans</subject><subject>Isocitrate Dehydrogenase - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Survival Analysis</subject><subject>Tumor Microenvironment</subject><subject>ZNF311</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaZYkf6CHomMu62gsf8jQS7LkYyE0PSQEehGyNN5qa0sbSU7pv6_d3eTYuWgYnvcFPYR8BpYBg-pim_12OGY5yyFjPGNV8YEsQNRiKeqqOXrfS3ZMzmLcsmk4FKLmn8gx53VRsaZZkM334DfOx2Q1vbJ-UOEXBvrj2w0HoMoZuk6RrnwI2KtkvaPPNv2kj-PgA52jAWOcz__QYRgd0rXrbJ-CShipdfS2n2tPycdO9RHPDu8Jebq5flzdLe8fbtery_ul5mWVllAzaAWgUU3R6bY0rTYdUxxUJ1TDa9YiFmWDbQUw3UxXaCibWqiSCaWN5ifkfN-7C_5lxJjkYKPGvlcO_RhlXjJelTnkYkLzPaqDjzFgJ3fBTgL-SGBydiy3cnYsZ8eScTk5nkJfDv1jO6B5j7wZnYCvewCnX75aDDJqi06jsQF1ksbb__X_BRBWjnU</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Ge, Xinqi</creator><creator>Jiang, Shichen</creator><creator>Wang, Ziheng</creator><creator>Hu, Nan</creator><creator>Jiang, Rui</creator><creator>Cai, Zishu</creator><creator>Wu, Bin</creator><creator>Zhang, Yu</creator><creator>Gong, Peipei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8873-732X</orcidid></search><sort><creationdate>202107</creationdate><title>Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma</title><author>Ge, Xinqi ; Jiang, Shichen ; Wang, Ziheng ; Hu, Nan ; Jiang, Rui ; Cai, Zishu ; Wu, Bin ; Zhang, Yu ; Gong, Peipei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-1701b81eda94fcb5dbcdf0a31af8a9370bee459eb6111afdf4c15978a508acdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Biomarkers, Tumor - blood</topic><topic>Brain Neoplasms - blood</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - immunology</topic><topic>CGGA</topic><topic>CIBERSORT</topic><topic>Databases, Genetic</topic><topic>DNA-Binding Proteins - blood</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>GEPIA</topic><topic>Glioma</topic><topic>Glioma - blood</topic><topic>Glioma - diagnosis</topic><topic>Glioma - immunology</topic><topic>Humans</topic><topic>Isocitrate Dehydrogenase - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Survival Analysis</topic><topic>Tumor Microenvironment</topic><topic>ZNF311</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ge, Xinqi</creatorcontrib><creatorcontrib>Jiang, Shichen</creatorcontrib><creatorcontrib>Wang, Ziheng</creatorcontrib><creatorcontrib>Hu, Nan</creatorcontrib><creatorcontrib>Jiang, Rui</creatorcontrib><creatorcontrib>Cai, Zishu</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Gong, Peipei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ge, Xinqi</au><au>Jiang, Shichen</au><au>Wang, Ziheng</au><au>Hu, Nan</au><au>Jiang, Rui</au><au>Cai, Zishu</au><au>Wu, Bin</au><au>Zhang, Yu</au><au>Gong, Peipei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2021-07</date><risdate>2021</risdate><volume>151</volume><spage>e37</spage><epage>e46</epage><pages>e37-e46</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Gliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes.
Validation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.
According to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.
Based on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33746099</pmid><doi>10.1016/j.wneu.2021.03.064</doi><orcidid>https://orcid.org/0000-0001-8873-732X</orcidid></addata></record> |
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| subjects | Adult Aged Algorithms Biomarkers, Tumor - blood Brain Neoplasms - blood Brain Neoplasms - diagnosis Brain Neoplasms - immunology CGGA CIBERSORT Databases, Genetic DNA-Binding Proteins - blood Female Gene Expression Profiling Gene Expression Regulation, Neoplastic GEPIA Glioma Glioma - blood Glioma - diagnosis Glioma - immunology Humans Isocitrate Dehydrogenase - blood Male Middle Aged Prognosis RNA, Messenger - biosynthesis RNA, Messenger - genetics Survival Analysis Tumor Microenvironment ZNF311 |
| title | Prognostic Biomarker ZNF311 and Its Correlation With Tumor Progression and Immune Infiltrates in Glioma |
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