The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats
Rationale Obesity is considered one of the major global health problems and increases the risk of several medical complications, such as diabetes and mental illnesses. Objective The present study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on obesity parameters, behaviora...
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| Veröffentlicht in: | Psychopharmacology 2021-07, Vol.238 (7), p.1937-1951 |
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| creator | Rodrigues, Karline C. Bortolatto, Cristiani F. da Motta, Ketlyn P. de Oliveira, Renata L. Paltian, Jaini J. Krüger, Roberta Roman, Silvane S. Boeira, Silvana P. Alves, Diego Wilhelm, Ethel Antunes Luchese, Cristiane |
| description | Rationale
Obesity is considered one of the major global health problems and increases the risk of several medical complications, such as diabetes and mental illnesses.
Objective
The present study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on obesity parameters, behavioral and neurochemical alterations in hypothalamic obese rats. Methods: Male Wistar rats received subcutaneous neonatal injections of monosodium glutamate (MSG, 4g/kg) or saline. After the Lee Index evaluation, rats were divided into groups and treated with 4-PSQ (5 mg/kg, intragastric route) or canola oil once a day (post-natal days (PND) 60→76). Open-field, elevated plus-maze, forced swim task, object recognition/location memory, and stepdown inhibitory avoidance tasks were conducted from PND 66 to 74. On PND 76, rats were euthanized and epididymal fat, blood, cerebral cortex, andhippocampus were removed. Blood biochemical parameters and cortical/hippocampal acetylcholinesterase (AChE) and Na /K -ATPase activities were assessed.
Results
MSG increased the Lee Index characterizing the chemically induced hypothalamic obesity model. 4-PSQ reversed the increases of epididymal fat, blood glucose, and triglyceride levels caused by MSG exposure. 4-PSQ attenuated anxiety-like and depression-like behaviors induced by neonatal administrations of MSG. Memory deficits found in MSG-obese rats were reversed by treatment with 4-PSQ. Neurochemical alterations produced by MSG evidenced by stimulation ofNa
+
/K
+
-ATPase and AChE activities in the cerebral cortex and hippocampus of rats were normalized by 4-PSQ treatment.
Conclusions
In brief, 4-PSQ therapy improved hypothalamic obesity-related parameters, as well as psychiatric symptoms, cognitive impairment, and neurochemical alterations found in obese rats.
Graphical abstract |
| doi_str_mv | 10.1007/s00213-021-05821-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2503449279</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A666521110</galeid><sourcerecordid>A666521110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-f0708d469dc6608af892113ea42dc7490cec461a0c7ce7054499709fd5ecd0a03</originalsourceid><addsrcrecordid>eNp9kctuHCEQRVGUKJ44-YEsIqRssmmneHTTLC0rL8lSNs4qC4Tpag8WDWNoFuOvD5NxnooCUiHBPUVVXUJeMjhjAOptAeBMdC100I8t7h-RDZOCdxwUf0w2AEJ0gvXjCXlWyi20JUf5lJwIoSSAZhvy9WqLNGLNad1itjusq3c0p4A0zdTSggGjr0s31-hWn6IN_h4neld9TMFHpD7S7X7XcBvs0th0jQVptmt5Tp7MNhR88XCeki_v311dfOwuP3_4dHF-2Tkp-drNoGCc5KAnNwww2nnUnDGBVvLJKanBoZMDs-CUQwW9lFor0PPUo5vAgjglb455dzndVSyrWXxxGIKNmGoxvAfRIK50k77-S3qbam5NHVSyb_PR8jfVjQ1ofJzTmq07JDXnwzD0rTx2-PbsH6q2J2xzSBFn3-7_APgRcDmVknE2u-wXm_eGgTk4ao6OmhbMd0fNvkGvHiqu1wtOP5EfFjaBOApKe4o3mH-19J-03wCnR6qh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545004949</pqid></control><display><type>article</type><title>The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats</title><source>SpringerLink Journals - AutoHoldings</source><creator>Rodrigues, Karline C. ; Bortolatto, Cristiani F. ; da Motta, Ketlyn P. ; de Oliveira, Renata L. ; Paltian, Jaini J. ; Krüger, Roberta ; Roman, Silvane S. ; Boeira, Silvana P. ; Alves, Diego ; Wilhelm, Ethel Antunes ; Luchese, Cristiane</creator><creatorcontrib>Rodrigues, Karline C. ; Bortolatto, Cristiani F. ; da Motta, Ketlyn P. ; de Oliveira, Renata L. ; Paltian, Jaini J. ; Krüger, Roberta ; Roman, Silvane S. ; Boeira, Silvana P. ; Alves, Diego ; Wilhelm, Ethel Antunes ; Luchese, Cristiane</creatorcontrib><description>Rationale
Obesity is considered one of the major global health problems and increases the risk of several medical complications, such as diabetes and mental illnesses.
Objective
The present study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on obesity parameters, behavioral and neurochemical alterations in hypothalamic obese rats. Methods: Male Wistar rats received subcutaneous neonatal injections of monosodium glutamate (MSG, 4g/kg) or saline. After the Lee Index evaluation, rats were divided into groups and treated with 4-PSQ (5 mg/kg, intragastric route) or canola oil once a day (post-natal days (PND) 60→76). Open-field, elevated plus-maze, forced swim task, object recognition/location memory, and stepdown inhibitory avoidance tasks were conducted from PND 66 to 74. On PND 76, rats were euthanized and epididymal fat, blood, cerebral cortex, andhippocampus were removed. Blood biochemical parameters and cortical/hippocampal acetylcholinesterase (AChE) and Na /K -ATPase activities were assessed.
Results
MSG increased the Lee Index characterizing the chemically induced hypothalamic obesity model. 4-PSQ reversed the increases of epididymal fat, blood glucose, and triglyceride levels caused by MSG exposure. 4-PSQ attenuated anxiety-like and depression-like behaviors induced by neonatal administrations of MSG. Memory deficits found in MSG-obese rats were reversed by treatment with 4-PSQ. Neurochemical alterations produced by MSG evidenced by stimulation ofNa
+
/K
+
-ATPase and AChE activities in the cerebral cortex and hippocampus of rats were normalized by 4-PSQ treatment.
Conclusions
In brief, 4-PSQ therapy improved hypothalamic obesity-related parameters, as well as psychiatric symptoms, cognitive impairment, and neurochemical alterations found in obese rats.
Graphical abstract</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-021-05821-y</identifier><identifier>PMID: 33740091</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetylcholinesterase ; Analysis ; Animal models ; Anxiety ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood sugar ; Cerebral cortex ; Cognitive ability ; Diabetes mellitus ; Dosage and administration ; Hippocampus ; Hypothalamus ; Memory ; Mental task performance ; Monosodium glutamate ; Na+/K+-exchanging ATPase ; Neonates ; Neurosciences ; Obesity ; Original Investigation ; Pattern recognition ; Pharmacology/Toxicology ; Physiological aspects ; Psychiatry ; Psychological aspects ; Public health ; Quinoline ; Rodents ; Selenium</subject><ispartof>Psychopharmacology, 2021-07, Vol.238 (7), p.1937-1951</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-f0708d469dc6608af892113ea42dc7490cec461a0c7ce7054499709fd5ecd0a03</citedby><cites>FETCH-LOGICAL-c442t-f0708d469dc6608af892113ea42dc7490cec461a0c7ce7054499709fd5ecd0a03</cites><orcidid>0000-0001-6001-0532</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-021-05821-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-021-05821-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33740091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues, Karline C.</creatorcontrib><creatorcontrib>Bortolatto, Cristiani F.</creatorcontrib><creatorcontrib>da Motta, Ketlyn P.</creatorcontrib><creatorcontrib>de Oliveira, Renata L.</creatorcontrib><creatorcontrib>Paltian, Jaini J.</creatorcontrib><creatorcontrib>Krüger, Roberta</creatorcontrib><creatorcontrib>Roman, Silvane S.</creatorcontrib><creatorcontrib>Boeira, Silvana P.</creatorcontrib><creatorcontrib>Alves, Diego</creatorcontrib><creatorcontrib>Wilhelm, Ethel Antunes</creatorcontrib><creatorcontrib>Luchese, Cristiane</creatorcontrib><title>The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Obesity is considered one of the major global health problems and increases the risk of several medical complications, such as diabetes and mental illnesses.
Objective
The present study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on obesity parameters, behavioral and neurochemical alterations in hypothalamic obese rats. Methods: Male Wistar rats received subcutaneous neonatal injections of monosodium glutamate (MSG, 4g/kg) or saline. After the Lee Index evaluation, rats were divided into groups and treated with 4-PSQ (5 mg/kg, intragastric route) or canola oil once a day (post-natal days (PND) 60→76). Open-field, elevated plus-maze, forced swim task, object recognition/location memory, and stepdown inhibitory avoidance tasks were conducted from PND 66 to 74. On PND 76, rats were euthanized and epididymal fat, blood, cerebral cortex, andhippocampus were removed. Blood biochemical parameters and cortical/hippocampal acetylcholinesterase (AChE) and Na /K -ATPase activities were assessed.
Results
MSG increased the Lee Index characterizing the chemically induced hypothalamic obesity model. 4-PSQ reversed the increases of epididymal fat, blood glucose, and triglyceride levels caused by MSG exposure. 4-PSQ attenuated anxiety-like and depression-like behaviors induced by neonatal administrations of MSG. Memory deficits found in MSG-obese rats were reversed by treatment with 4-PSQ. Neurochemical alterations produced by MSG evidenced by stimulation ofNa
+
/K
+
-ATPase and AChE activities in the cerebral cortex and hippocampus of rats were normalized by 4-PSQ treatment.
Conclusions
In brief, 4-PSQ therapy improved hypothalamic obesity-related parameters, as well as psychiatric symptoms, cognitive impairment, and neurochemical alterations found in obese rats.
Graphical abstract</description><subject>Acetylcholinesterase</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Anxiety</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood sugar</subject><subject>Cerebral cortex</subject><subject>Cognitive ability</subject><subject>Diabetes mellitus</subject><subject>Dosage and administration</subject><subject>Hippocampus</subject><subject>Hypothalamus</subject><subject>Memory</subject><subject>Mental task performance</subject><subject>Monosodium glutamate</subject><subject>Na+/K+-exchanging ATPase</subject><subject>Neonates</subject><subject>Neurosciences</subject><subject>Obesity</subject><subject>Original Investigation</subject><subject>Pattern recognition</subject><subject>Pharmacology/Toxicology</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Public health</subject><subject>Quinoline</subject><subject>Rodents</subject><subject>Selenium</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctuHCEQRVGUKJ44-YEsIqRssmmneHTTLC0rL8lSNs4qC4Tpag8WDWNoFuOvD5NxnooCUiHBPUVVXUJeMjhjAOptAeBMdC100I8t7h-RDZOCdxwUf0w2AEJ0gvXjCXlWyi20JUf5lJwIoSSAZhvy9WqLNGLNad1itjusq3c0p4A0zdTSggGjr0s31-hWn6IN_h4neld9TMFHpD7S7X7XcBvs0th0jQVptmt5Tp7MNhR88XCeki_v311dfOwuP3_4dHF-2Tkp-drNoGCc5KAnNwww2nnUnDGBVvLJKanBoZMDs-CUQwW9lFor0PPUo5vAgjglb455dzndVSyrWXxxGIKNmGoxvAfRIK50k77-S3qbam5NHVSyb_PR8jfVjQ1ofJzTmq07JDXnwzD0rTx2-PbsH6q2J2xzSBFn3-7_APgRcDmVknE2u-wXm_eGgTk4ao6OmhbMd0fNvkGvHiqu1wtOP5EfFjaBOApKe4o3mH-19J-03wCnR6qh</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Rodrigues, Karline C.</creator><creator>Bortolatto, Cristiani F.</creator><creator>da Motta, Ketlyn P.</creator><creator>de Oliveira, Renata L.</creator><creator>Paltian, Jaini J.</creator><creator>Krüger, Roberta</creator><creator>Roman, Silvane S.</creator><creator>Boeira, Silvana P.</creator><creator>Alves, Diego</creator><creator>Wilhelm, Ethel Antunes</creator><creator>Luchese, Cristiane</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6001-0532</orcidid></search><sort><creationdate>20210701</creationdate><title>The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats</title><author>Rodrigues, Karline C. ; Bortolatto, Cristiani F. ; da Motta, Ketlyn P. ; de Oliveira, Renata L. ; Paltian, Jaini J. ; Krüger, Roberta ; Roman, Silvane S. ; Boeira, Silvana P. ; Alves, Diego ; Wilhelm, Ethel Antunes ; Luchese, Cristiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-f0708d469dc6608af892113ea42dc7490cec461a0c7ce7054499709fd5ecd0a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylcholinesterase</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Anxiety</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Blood sugar</topic><topic>Cerebral cortex</topic><topic>Cognitive ability</topic><topic>Diabetes mellitus</topic><topic>Dosage and administration</topic><topic>Hippocampus</topic><topic>Hypothalamus</topic><topic>Memory</topic><topic>Mental task performance</topic><topic>Monosodium glutamate</topic><topic>Na+/K+-exchanging ATPase</topic><topic>Neonates</topic><topic>Neurosciences</topic><topic>Obesity</topic><topic>Original Investigation</topic><topic>Pattern recognition</topic><topic>Pharmacology/Toxicology</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Public health</topic><topic>Quinoline</topic><topic>Rodents</topic><topic>Selenium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigues, Karline C.</creatorcontrib><creatorcontrib>Bortolatto, Cristiani F.</creatorcontrib><creatorcontrib>da Motta, Ketlyn P.</creatorcontrib><creatorcontrib>de Oliveira, Renata L.</creatorcontrib><creatorcontrib>Paltian, Jaini J.</creatorcontrib><creatorcontrib>Krüger, Roberta</creatorcontrib><creatorcontrib>Roman, Silvane S.</creatorcontrib><creatorcontrib>Boeira, Silvana P.</creatorcontrib><creatorcontrib>Alves, Diego</creatorcontrib><creatorcontrib>Wilhelm, Ethel Antunes</creatorcontrib><creatorcontrib>Luchese, Cristiane</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues, Karline C.</au><au>Bortolatto, Cristiani F.</au><au>da Motta, Ketlyn P.</au><au>de Oliveira, Renata L.</au><au>Paltian, Jaini J.</au><au>Krüger, Roberta</au><au>Roman, Silvane S.</au><au>Boeira, Silvana P.</au><au>Alves, Diego</au><au>Wilhelm, Ethel Antunes</au><au>Luchese, Cristiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>238</volume><issue>7</issue><spage>1937</spage><epage>1951</epage><pages>1937-1951</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Obesity is considered one of the major global health problems and increases the risk of several medical complications, such as diabetes and mental illnesses.
Objective
The present study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on obesity parameters, behavioral and neurochemical alterations in hypothalamic obese rats. Methods: Male Wistar rats received subcutaneous neonatal injections of monosodium glutamate (MSG, 4g/kg) or saline. After the Lee Index evaluation, rats were divided into groups and treated with 4-PSQ (5 mg/kg, intragastric route) or canola oil once a day (post-natal days (PND) 60→76). Open-field, elevated plus-maze, forced swim task, object recognition/location memory, and stepdown inhibitory avoidance tasks were conducted from PND 66 to 74. On PND 76, rats were euthanized and epididymal fat, blood, cerebral cortex, andhippocampus were removed. Blood biochemical parameters and cortical/hippocampal acetylcholinesterase (AChE) and Na /K -ATPase activities were assessed.
Results
MSG increased the Lee Index characterizing the chemically induced hypothalamic obesity model. 4-PSQ reversed the increases of epididymal fat, blood glucose, and triglyceride levels caused by MSG exposure. 4-PSQ attenuated anxiety-like and depression-like behaviors induced by neonatal administrations of MSG. Memory deficits found in MSG-obese rats were reversed by treatment with 4-PSQ. Neurochemical alterations produced by MSG evidenced by stimulation ofNa
+
/K
+
-ATPase and AChE activities in the cerebral cortex and hippocampus of rats were normalized by 4-PSQ treatment.
Conclusions
In brief, 4-PSQ therapy improved hypothalamic obesity-related parameters, as well as psychiatric symptoms, cognitive impairment, and neurochemical alterations found in obese rats.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33740091</pmid><doi>10.1007/s00213-021-05821-y</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-6001-0532</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Psychopharmacology, 2021-07, Vol.238 (7), p.1937-1951 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acetylcholinesterase Analysis Animal models Anxiety Biomedical and Life Sciences Biomedicine Blood Blood sugar Cerebral cortex Cognitive ability Diabetes mellitus Dosage and administration Hippocampus Hypothalamus Memory Mental task performance Monosodium glutamate Na+/K+-exchanging ATPase Neonates Neurosciences Obesity Original Investigation Pattern recognition Pharmacology/Toxicology Physiological aspects Psychiatry Psychological aspects Public health Quinoline Rodents Selenium |
| title | The neurotherapeutic role of a selenium-functionalized quinoline in hypothalamic obese rats |
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