Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival and protecting them from immunotherapy and chemotherapy-induced death. It remains largely unknown how the specific signaling pathway exerts the tumor microenvironment in head and neck squa...
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| Veröffentlicht in: | Cancer letters 2021-06, Vol.507, p.55-69 |
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| container_title | Cancer letters |
| container_volume | 507 |
| creator | Wang, Ganping Zhang, Ming Cheng, Maosheng Wang, Xiaochen Li, Kang Chen, Jianwen Chen, Zhi Chen, Shuang Chen, Jie Xiong, Gan Xu, Xiuyun Wang, Cheng Chen, Demeng |
| description | The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival and protecting them from immunotherapy and chemotherapy-induced death. It remains largely unknown how the specific signaling pathway exerts the tumor microenvironment in head and neck squamous cell carcinoma though previous studies have elucidated the regulatory mechanisms involve in tumor immune microenvironment, stromal cells, tumor angiogenesis and cancer stem cell. These components are responsible for tumor progression as well as anti-cancer therapy resistance, leading to rapid tumor growth and treatment failure. In this review, we focus on discussing the interaction between tumor cells and the surrounding components for better understanding of anti-cancer treatment ineffectiveness and its underlying molecular mechanisms.
•The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival, promoting tumor recurrence and anti-cancer treatment resistance.•It remains largely unknown the molecular mechanism of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though previous studies have proved some factors involve in tumor immune microenvironment, such as stromal cells, tumor angiogenesis and cancer stem cell.•Here, we discuss the recent research about the interaction between tumor cells and the surrounding components for better understanding of regulatory network driven by the tumor microenvironment in HNSCC. |
| doi_str_mv | 10.1016/j.canlet.2021.03.009 |
| format | Article |
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•The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival, promoting tumor recurrence and anti-cancer treatment resistance.•It remains largely unknown the molecular mechanism of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though previous studies have proved some factors involve in tumor immune microenvironment, such as stromal cells, tumor angiogenesis and cancer stem cell.•Here, we discuss the recent research about the interaction between tumor cells and the surrounding components for better understanding of regulatory network driven by the tumor microenvironment in HNSCC.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2021.03.009</identifier><identifier>PMID: 33741424</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Angiogenesis ; Antibodies ; Antigens ; Cancer stem cells ; Cancer therapies ; Chemotherapy ; Cytokines ; Cytotoxicity ; Head & neck cancer ; HNSCC ; Immune cells ; Immunotherapy ; Lymphocytes ; Medical prognosis ; Metastasis ; Molecular modelling ; Mutation ; Peptides ; Signal transduction ; Squamous cell carcinoma ; Stem cells ; Stromal cells ; T cell receptors ; Tumor angiogenesis ; Tumor cells ; Tumor microenvironment ; Tumors</subject><ispartof>Cancer letters, 2021-06, Vol.507, p.55-69</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.</rights><rights>2021. The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-5ab807f7ec4a437dd337fc84f1f2baed2f0c9cdf80ff41346c23bf7b5abc623</citedby><cites>FETCH-LOGICAL-c487t-5ab807f7ec4a437dd337fc84f1f2baed2f0c9cdf80ff41346c23bf7b5abc623</cites><orcidid>0000-0003-3308-686X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2021.03.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33741424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Ganping</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Cheng, Maosheng</creatorcontrib><creatorcontrib>Wang, Xiaochen</creatorcontrib><creatorcontrib>Li, Kang</creatorcontrib><creatorcontrib>Chen, Jianwen</creatorcontrib><creatorcontrib>Chen, Zhi</creatorcontrib><creatorcontrib>Chen, Shuang</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Xiong, Gan</creatorcontrib><creatorcontrib>Xu, Xiuyun</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Chen, Demeng</creatorcontrib><title>Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival and protecting them from immunotherapy and chemotherapy-induced death. It remains largely unknown how the specific signaling pathway exerts the tumor microenvironment in head and neck squamous cell carcinoma though previous studies have elucidated the regulatory mechanisms involve in tumor immune microenvironment, stromal cells, tumor angiogenesis and cancer stem cell. These components are responsible for tumor progression as well as anti-cancer therapy resistance, leading to rapid tumor growth and treatment failure. In this review, we focus on discussing the interaction between tumor cells and the surrounding components for better understanding of anti-cancer treatment ineffectiveness and its underlying molecular mechanisms.
•The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival, promoting tumor recurrence and anti-cancer treatment resistance.•It remains largely unknown the molecular mechanism of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though previous studies have proved some factors involve in tumor immune microenvironment, such as stromal cells, tumor angiogenesis and cancer stem cell.•Here, we discuss the recent research about the interaction between tumor cells and the surrounding components for better understanding of regulatory network driven by the tumor microenvironment in HNSCC.</description><subject>Angiogenesis</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Cancer stem cells</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Head & neck cancer</subject><subject>HNSCC</subject><subject>Immune cells</subject><subject>Immunotherapy</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Molecular modelling</subject><subject>Mutation</subject><subject>Peptides</subject><subject>Signal transduction</subject><subject>Squamous cell carcinoma</subject><subject>Stem cells</subject><subject>Stromal cells</subject><subject>T cell receptors</subject><subject>Tumor angiogenesis</subject><subject>Tumor cells</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kT9vFDEUxC0EIpfAN0DIEg3NLs9_dr1HgRRFJCBFoiC95bWfiY-zndi7kfLt8XGBgoLqNb-ZN5oh5A2DngEbP-x6a9Iel54DZz2IHmD7jGzYpHinthM8JxsQIDsxieGEnNa6A4BBquElORFCSSa53BB3s8ZcaAy2ZEwPoeQUMS00JHqLxlGTHE1of9J6v5qY10ot7vfUmmJDytF8pJdrskvIqf5mC_5Y92bJ5ZFGtLcmhRrrK_LCm33F10_3jHy__Hxz8aW7_nb19eL8urNyUks3mHkC5RVaaaRQzrWY3k7SM89ng457sFvr_ATeSybkaLmYvZqbzo5cnJH3R9e7ku9XrIuOoR7SmoQtuOYDCCknNm4b-u4fdJfXklq2A6XGYeBcNkoeqdZNrQW9vishmvKoGejDBnqnjxvowwYahG4bNNnbJ_N1juj-iv6U3oBPRwBbFw8Bi642YLLoQkG7aJfD_z_8AtGvm5Y</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Wang, Ganping</creator><creator>Zhang, Ming</creator><creator>Cheng, Maosheng</creator><creator>Wang, Xiaochen</creator><creator>Li, Kang</creator><creator>Chen, Jianwen</creator><creator>Chen, Zhi</creator><creator>Chen, Shuang</creator><creator>Chen, Jie</creator><creator>Xiong, Gan</creator><creator>Xu, Xiuyun</creator><creator>Wang, Cheng</creator><creator>Chen, Demeng</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3308-686X</orcidid></search><sort><creationdate>20210601</creationdate><title>Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms</title><author>Wang, Ganping ; Zhang, Ming ; Cheng, Maosheng ; Wang, Xiaochen ; Li, Kang ; Chen, Jianwen ; Chen, Zhi ; Chen, Shuang ; Chen, Jie ; Xiong, Gan ; Xu, Xiuyun ; Wang, Cheng ; Chen, Demeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-5ab807f7ec4a437dd337fc84f1f2baed2f0c9cdf80ff41346c23bf7b5abc623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiogenesis</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Cancer stem cells</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Head & neck cancer</topic><topic>HNSCC</topic><topic>Immune cells</topic><topic>Immunotherapy</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Molecular modelling</topic><topic>Mutation</topic><topic>Peptides</topic><topic>Signal transduction</topic><topic>Squamous cell carcinoma</topic><topic>Stem cells</topic><topic>Stromal cells</topic><topic>T cell receptors</topic><topic>Tumor angiogenesis</topic><topic>Tumor cells</topic><topic>Tumor microenvironment</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ganping</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Cheng, Maosheng</creatorcontrib><creatorcontrib>Wang, Xiaochen</creatorcontrib><creatorcontrib>Li, Kang</creatorcontrib><creatorcontrib>Chen, Jianwen</creatorcontrib><creatorcontrib>Chen, Zhi</creatorcontrib><creatorcontrib>Chen, Shuang</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Xiong, Gan</creatorcontrib><creatorcontrib>Xu, Xiuyun</creatorcontrib><creatorcontrib>Wang, Cheng</creatorcontrib><creatorcontrib>Chen, Demeng</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ganping</au><au>Zhang, Ming</au><au>Cheng, Maosheng</au><au>Wang, Xiaochen</au><au>Li, Kang</au><au>Chen, Jianwen</au><au>Chen, Zhi</au><au>Chen, Shuang</au><au>Chen, Jie</au><au>Xiong, Gan</au><au>Xu, Xiuyun</au><au>Wang, Cheng</au><au>Chen, Demeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>507</volume><spage>55</spage><epage>69</epage><pages>55-69</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival and protecting them from immunotherapy and chemotherapy-induced death. 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•The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival, promoting tumor recurrence and anti-cancer treatment resistance.•It remains largely unknown the molecular mechanism of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) though previous studies have proved some factors involve in tumor immune microenvironment, such as stromal cells, tumor angiogenesis and cancer stem cell.•Here, we discuss the recent research about the interaction between tumor cells and the surrounding components for better understanding of regulatory network driven by the tumor microenvironment in HNSCC.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33741424</pmid><doi>10.1016/j.canlet.2021.03.009</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-3308-686X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Antibodies Antigens Cancer stem cells Cancer therapies Chemotherapy Cytokines Cytotoxicity Head & neck cancer HNSCC Immune cells Immunotherapy Lymphocytes Medical prognosis Metastasis Molecular modelling Mutation Peptides Signal transduction Squamous cell carcinoma Stem cells Stromal cells T cell receptors Tumor angiogenesis Tumor cells Tumor microenvironment Tumors |
| title | Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms |
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