Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis
Abstract Objectives The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic DM (CADM). Nevertheless, a subset of MDA5+ patients have a favourable prognosis. We aimed to determine the possibility of u...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2021-12, Vol.61 (1), p.430-439 |
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| container_title | Rheumatology (Oxford, England) |
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| creator | Chen, Mengya Zhao, Qian Diao, Licheng Xue, Ke Ruan, Yeping Xue, Feng Li, Jian Shi, Ruofei Pan, Meng Zheng, Jie Cao, Hua |
| description | Abstract
Objectives
The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic DM (CADM). Nevertheless, a subset of MDA5+ patients have a favourable prognosis. We aimed to determine the possibility of using anti-MDA5 antibody isotypes and IgG subclasses for evaluating ILD risk.
Methods
The isotypes (IgG, IgA and IgM) of anti-MDA5 were detected in serum samples of 36 anti-MDA5+ patients with DM/CADM using ELISA. IgG subclasses of anti-MDA5 antibodies were further investigated. Laboratory findings and cumulative survival were analysed based on the isotypes of anti-MDA5 and subclasses of anti-MDA5 IgG.
Results
Among the MDA5+ patients with DM/CADM, the positive rates of anti-MDA5 IgG, IgA and IgM were 100, 97 and 6%, respectively. The positive rates of anti-MDA5 IgG1, IgG2, IgG3 and IgG4 were 72, 25, 0 and 28%, respectively. The incidence of acute interstitial pneumonia, mortality rate and serum ferritin were significantly higher in anti-MDA5 IgG1+ patients than in anti-MDA5 IgG1− patients with DM/CADM (P = 0.0027, 0.015, 0.0011, respectively). The sensitivity and specificity of anti-MDA5 IgG1 for predicting mortality were 100 and 41.7%, respectively. A combination of anti-MDA5 IgG1 and IgG4 for predicting mortality yielded better specificity (87.5%).
Conclusion
IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD. |
| doi_str_mv | 10.1093/rheumatology/keab268 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2503440461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/rheumatology/keab268</oup_id><sourcerecordid>2503440461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2982-a8f05e1684b70c75b8577f43295ece2e8762b9155a11cb42bf20b987f11391873</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0E4v0HCHlZhEL9TJwlKk8JxAbWke2MiyGJi50s-vektFQsWc3o6sydmYvQGSVXlJR8Gt9haHUfmjBfTj9BG5arHXRIRc4ywjnb3fZMHKCjlD4IIZJytY8OOC8Ey3N2iLobn_rozdD70OHgsO56n7XQ6C60GtfeOYgwavoH0CkFO_ZQ4zl0gCWePN9cywv8OL_HaTC2GQlI2Hd4pV_iGuLqyHYZku99OkF7TjcJTjf1GL3d3b7OHrKnl_vH2fVTZlmpWKaVIxJoroQpiC2kUbIonOCslGCBgSpyZkoqpabUGsGMY8SUqnCU8pKqgh-jydp3EcPXAKmvWp8sNONbEIZUMUm4EETkdETFGrUxpBTBVYvoWx2XFSXVKunqb9LVJulx7HyzYTAt1Nuh32hHYLoGwrD4n-U3YfmO9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2503440461</pqid></control><display><type>article</type><title>Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Chen, Mengya ; Zhao, Qian ; Diao, Licheng ; Xue, Ke ; Ruan, Yeping ; Xue, Feng ; Li, Jian ; Shi, Ruofei ; Pan, Meng ; Zheng, Jie ; Cao, Hua</creator><creatorcontrib>Chen, Mengya ; Zhao, Qian ; Diao, Licheng ; Xue, Ke ; Ruan, Yeping ; Xue, Feng ; Li, Jian ; Shi, Ruofei ; Pan, Meng ; Zheng, Jie ; Cao, Hua</creatorcontrib><description>Abstract
Objectives
The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic DM (CADM). Nevertheless, a subset of MDA5+ patients have a favourable prognosis. We aimed to determine the possibility of using anti-MDA5 antibody isotypes and IgG subclasses for evaluating ILD risk.
Methods
The isotypes (IgG, IgA and IgM) of anti-MDA5 were detected in serum samples of 36 anti-MDA5+ patients with DM/CADM using ELISA. IgG subclasses of anti-MDA5 antibodies were further investigated. Laboratory findings and cumulative survival were analysed based on the isotypes of anti-MDA5 and subclasses of anti-MDA5 IgG.
Results
Among the MDA5+ patients with DM/CADM, the positive rates of anti-MDA5 IgG, IgA and IgM were 100, 97 and 6%, respectively. The positive rates of anti-MDA5 IgG1, IgG2, IgG3 and IgG4 were 72, 25, 0 and 28%, respectively. The incidence of acute interstitial pneumonia, mortality rate and serum ferritin were significantly higher in anti-MDA5 IgG1+ patients than in anti-MDA5 IgG1− patients with DM/CADM (P = 0.0027, 0.015, 0.0011, respectively). The sensitivity and specificity of anti-MDA5 IgG1 for predicting mortality were 100 and 41.7%, respectively. A combination of anti-MDA5 IgG1 and IgG4 for predicting mortality yielded better specificity (87.5%).
Conclusion
IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keab268</identifier><identifier>PMID: 33742662</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Biomarkers - blood ; China - epidemiology ; Dermatomyositis - diagnosis ; Dermatomyositis - immunology ; Dermatomyositis - mortality ; Female ; Humans ; Immunoglobulin Isotypes - blood ; Interferon-Induced Helicase, IFIH1 - immunology ; Lung Diseases, Interstitial - etiology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Young Adult</subject><ispartof>Rheumatology (Oxford, England), 2021-12, Vol.61 (1), p.430-439</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2982-a8f05e1684b70c75b8577f43295ece2e8762b9155a11cb42bf20b987f11391873</citedby><cites>FETCH-LOGICAL-c2982-a8f05e1684b70c75b8577f43295ece2e8762b9155a11cb42bf20b987f11391873</cites><orcidid>0000-0001-5908-6206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33742662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Mengya</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Diao, Licheng</creatorcontrib><creatorcontrib>Xue, Ke</creatorcontrib><creatorcontrib>Ruan, Yeping</creatorcontrib><creatorcontrib>Xue, Feng</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Shi, Ruofei</creatorcontrib><creatorcontrib>Pan, Meng</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><creatorcontrib>Cao, Hua</creatorcontrib><title>Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract
Objectives
The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic DM (CADM). Nevertheless, a subset of MDA5+ patients have a favourable prognosis. We aimed to determine the possibility of using anti-MDA5 antibody isotypes and IgG subclasses for evaluating ILD risk.
Methods
The isotypes (IgG, IgA and IgM) of anti-MDA5 were detected in serum samples of 36 anti-MDA5+ patients with DM/CADM using ELISA. IgG subclasses of anti-MDA5 antibodies were further investigated. Laboratory findings and cumulative survival were analysed based on the isotypes of anti-MDA5 and subclasses of anti-MDA5 IgG.
Results
Among the MDA5+ patients with DM/CADM, the positive rates of anti-MDA5 IgG, IgA and IgM were 100, 97 and 6%, respectively. The positive rates of anti-MDA5 IgG1, IgG2, IgG3 and IgG4 were 72, 25, 0 and 28%, respectively. The incidence of acute interstitial pneumonia, mortality rate and serum ferritin were significantly higher in anti-MDA5 IgG1+ patients than in anti-MDA5 IgG1− patients with DM/CADM (P = 0.0027, 0.015, 0.0011, respectively). The sensitivity and specificity of anti-MDA5 IgG1 for predicting mortality were 100 and 41.7%, respectively. A combination of anti-MDA5 IgG1 and IgG4 for predicting mortality yielded better specificity (87.5%).
Conclusion
IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>China - epidemiology</subject><subject>Dermatomyositis - diagnosis</subject><subject>Dermatomyositis - immunology</subject><subject>Dermatomyositis - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin Isotypes - blood</subject><subject>Interferon-Induced Helicase, IFIH1 - immunology</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0E4v0HCHlZhEL9TJwlKk8JxAbWke2MiyGJi50s-vektFQsWc3o6sydmYvQGSVXlJR8Gt9haHUfmjBfTj9BG5arHXRIRc4ywjnb3fZMHKCjlD4IIZJytY8OOC8Ey3N2iLobn_rozdD70OHgsO56n7XQ6C60GtfeOYgwavoH0CkFO_ZQ4zl0gCWePN9cywv8OL_HaTC2GQlI2Hd4pV_iGuLqyHYZku99OkF7TjcJTjf1GL3d3b7OHrKnl_vH2fVTZlmpWKaVIxJoroQpiC2kUbIonOCslGCBgSpyZkoqpabUGsGMY8SUqnCU8pKqgh-jydp3EcPXAKmvWp8sNONbEIZUMUm4EETkdETFGrUxpBTBVYvoWx2XFSXVKunqb9LVJulx7HyzYTAt1Nuh32hHYLoGwrD4n-U3YfmO9A</recordid><startdate>20211224</startdate><enddate>20211224</enddate><creator>Chen, Mengya</creator><creator>Zhao, Qian</creator><creator>Diao, Licheng</creator><creator>Xue, Ke</creator><creator>Ruan, Yeping</creator><creator>Xue, Feng</creator><creator>Li, Jian</creator><creator>Shi, Ruofei</creator><creator>Pan, Meng</creator><creator>Zheng, Jie</creator><creator>Cao, Hua</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5908-6206</orcidid></search><sort><creationdate>20211224</creationdate><title>Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis</title><author>Chen, Mengya ; Zhao, Qian ; Diao, Licheng ; Xue, Ke ; Ruan, Yeping ; Xue, Feng ; Li, Jian ; Shi, Ruofei ; Pan, Meng ; Zheng, Jie ; Cao, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2982-a8f05e1684b70c75b8577f43295ece2e8762b9155a11cb42bf20b987f11391873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>China - epidemiology</topic><topic>Dermatomyositis - diagnosis</topic><topic>Dermatomyositis - immunology</topic><topic>Dermatomyositis - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin Isotypes - blood</topic><topic>Interferon-Induced Helicase, IFIH1 - immunology</topic><topic>Lung Diseases, Interstitial - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Mengya</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Diao, Licheng</creatorcontrib><creatorcontrib>Xue, Ke</creatorcontrib><creatorcontrib>Ruan, Yeping</creatorcontrib><creatorcontrib>Xue, Feng</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Shi, Ruofei</creatorcontrib><creatorcontrib>Pan, Meng</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><creatorcontrib>Cao, Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Mengya</au><au>Zhao, Qian</au><au>Diao, Licheng</au><au>Xue, Ke</au><au>Ruan, Yeping</au><au>Xue, Feng</au><au>Li, Jian</au><au>Shi, Ruofei</au><au>Pan, Meng</au><au>Zheng, Jie</au><au>Cao, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2021-12-24</date><risdate>2021</risdate><volume>61</volume><issue>1</issue><spage>430</spage><epage>439</epage><pages>430-439</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract
Objectives
The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic DM (CADM). Nevertheless, a subset of MDA5+ patients have a favourable prognosis. We aimed to determine the possibility of using anti-MDA5 antibody isotypes and IgG subclasses for evaluating ILD risk.
Methods
The isotypes (IgG, IgA and IgM) of anti-MDA5 were detected in serum samples of 36 anti-MDA5+ patients with DM/CADM using ELISA. IgG subclasses of anti-MDA5 antibodies were further investigated. Laboratory findings and cumulative survival were analysed based on the isotypes of anti-MDA5 and subclasses of anti-MDA5 IgG.
Results
Among the MDA5+ patients with DM/CADM, the positive rates of anti-MDA5 IgG, IgA and IgM were 100, 97 and 6%, respectively. The positive rates of anti-MDA5 IgG1, IgG2, IgG3 and IgG4 were 72, 25, 0 and 28%, respectively. The incidence of acute interstitial pneumonia, mortality rate and serum ferritin were significantly higher in anti-MDA5 IgG1+ patients than in anti-MDA5 IgG1− patients with DM/CADM (P = 0.0027, 0.015, 0.0011, respectively). The sensitivity and specificity of anti-MDA5 IgG1 for predicting mortality were 100 and 41.7%, respectively. A combination of anti-MDA5 IgG1 and IgG4 for predicting mortality yielded better specificity (87.5%).
Conclusion
IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33742662</pmid><doi>10.1093/rheumatology/keab268</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5908-6206</orcidid></addata></record> |
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| ispartof | Rheumatology (Oxford, England), 2021-12, Vol.61 (1), p.430-439 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Biomarkers - blood China - epidemiology Dermatomyositis - diagnosis Dermatomyositis - immunology Dermatomyositis - mortality Female Humans Immunoglobulin Isotypes - blood Interferon-Induced Helicase, IFIH1 - immunology Lung Diseases, Interstitial - etiology Male Middle Aged Prognosis Retrospective Studies Young Adult |
| title | Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis |
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