B7-H3, Negatively Regulated by miR-128, Promotes Colorectal Cancer Cell Proliferation and Migration

Background B7 homolog 3 (B7-H3), a member of the immunoregulatory ligand B7 family, is pivotal in T-cell-mediated immune response. It is widely expressed in diverse human tumors and its high expression indicates the poor prognosis of the patients. Nonetheless, B7-H3’s role in colorectal cancer (CRC)...

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Veröffentlicht in:	Cell biochemistry and biophysics 2021-06, Vol.79 (2), p.397-405
Hauptverfasser:	Hu, Xiaomao, Xu, Minxian, Hu, Yangzhi, Li, Na, Zhou, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagomirs - metabolism B7 antigen B7 Antigens - antagonists & inhibitors B7 Antigens - genetics B7 Antigens - metabolism Base Sequence Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cancer Cell Biology Cell culture Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cholecystokinin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Gene expression Homology Humans Immune response Immune response (cell-mediated) Immune system Immunohistochemistry Immunoregulation Life Sciences Lymph nodes Lymphocytes T Male Metastases MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Middle Aged mRNA Multiplication Neoplasm Staging Original Paper Pharmacology/Toxicology Polymerase chain reaction Reporter gene RNA Interference RNA, Small Interfering - metabolism Sequence Alignment Survival Rate Target recognition Tumors Western blotting Wound healing
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