Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC‐1α activation

Mesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune‐mediated diseases. Our previous study had demonstrated that MSCs could elicit macrophages (Mφ) into anti‐inflammatory phenotypes, and alleviate kidney injury in diabetic nephropathy (DN) mice via improving mitochondr...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2021-07, Vol.39 (7), p.913-928
Hauptverfasser:	Yuan, Yujia, Yuan, Longhui, Li, Lan, Liu, Fei, Liu, Jingping, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animals Autophagy Biosynthesis Cell activation Diabetes Diabetes Mellitus Diabetic Nephropathies - therapy Diabetic nephropathy Inflammation Inflammation - metabolism Inflammatory response Injuries Kidney Kidneys Macrophages Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mice Microenvironments Mitochondria mitochondrial transfer Nephropathy PGC‐1α Phagocytosis Phenotypes Rotenone Stem cell transplantation Stem cells TFEB
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