Recent advances in development of hetero-bivalent kinase inhibitors

Identifying a pharmacological agent that targets only one of more than 500 kinases present in humans is an important challenge. One potential solution to this problem is the development of bivalent kinase inhibitors, which consist of two connected fragments, each bind to a dissimilar binding site of...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-04, Vol.216, p.113318-113318, Article 113318
Hauptverfasser:	Lee, Seungbeom, Kim, Jisu, Jo, Jeyun, Chang, Jae Won, Sim, Jaehoon, Yun, Hwayoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Hetero-bivalent Humans Kinase inhibitor Protein kinase Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Receptor, EphA1 - antagonists & inhibitors Receptor, EphA1 - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Type V inhibitor
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