Immunodetection of Lung IgG and IgM Antibodies against SARS-CoV‑2 via Enzymatic Liquefaction of Respiratory Samples from COVID-19 Patients

Lung-secreted IgG and IgM antibodies are valuable biomarkers for monitoring the local immune response against respiratory infections. These biomarkers are found in lower airway secretions that need to be liquefied prior to analysis. Traditional methods for sample liquefaction rely on reducing disulf...

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Veröffentlicht in:	Analytical chemistry (Washington) 2021-03, Vol.93 (12), p.5259-5266
Hauptverfasser:	Clemente, Antonio, Alba-Patiño, Alejandra, Santopolo, Giulia, Rojo-Molinero, Estrella, Oliver, Antonio, Borges, Marcio, Aranda, María, del Castillo, Alberto, de la Rica, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Antibodies Antibodies, Viral - immunology Antigens Biomarkers Catalase Chemistry Coronaviruses COVID-19 COVID-19 - immunology Damage prevention Disulfide bonds Dithiothreitol Enzyme-Linked Immunosorbent Assay Humans Immune response Immune system Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - immunology Infections Limit of Detection Liquefaction Lung - immunology Lungs Recognition SARS-CoV-2 - immunology Secretions Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Structural damage
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