Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children

Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of autism and developmental disorders 2022-02, Vol.52 (2), p.483-489
Hauptverfasser:	Horinouchi, Tomoko, Maeyama, Kaori, Nagai, Masashi, Mizobuchi, Masami, Takagi, Yasuko, Okada, Yuka, Kato, Takeshi, Nishimura, Mio, Kawasaki, Yoko, Yoshioka, Mieko, Takada, Satoshi, Matsumoto, Hisayuki, Nakamachi, Yuji, Saegusa, Jun, Fukushima, Sachiyo, Fujioka, Kazumichi, Tomioka, Kazumi, Nagase, Hiroaki, Nozu, Kandai, Iijima, Kazumoto, Nishimura, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles At Risk Persons Autism Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Autistic children Behavioral Science and Psychology Biochemistry Child Child and School Psychology Children Complications and side effects Composition Deoxyribonucleic acid DNA Female Gene frequency Genetic analysis Genetic polymorphisms Genotypes Glucuronosyltransferase - genetics Health aspects Humans Infant, Newborn Jaundice Jaundice, Neonatal - complications Neonatal jaundice Neonates Neurosciences Newborn babies Original Paper Pediatric research Pediatrics Perinatal Pervasive Developmental Disorders Physiology Polymorphism, Genetic Population genetics Pregnancy Protection and preservation Psychology Public Health Risk Factors Symptoms (Individual Disorders) Tissues Umbilical Cord
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	489
container_issue	2
container_start_page	483
container_title	Journal of autism and developmental disorders
container_volume	52
creator	Horinouchi, Tomoko Maeyama, Kaori Nagai, Masashi Mizobuchi, Masami Takagi, Yasuko Okada, Yuka Kato, Takeshi Nishimura, Mio Kawasaki, Yoko Yoshioka, Mieko Takada, Satoshi Matsumoto, Hisayuki Nakamachi, Yuji Saegusa, Jun Fukushima, Sachiyo Fujioka, Kazumichi Tomioka, Kazumi Nagase, Hiroaki Nozu, Kandai Iijima, Kazumoto Nishimura, Noriyuki
description	Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A128 (c.-41-40dup) , UGT1A16 (c.211 G > A), and UGT1A127 (c.686 C > A). The allele frequency of UGT1A16 (OR = 1.34, p = 0.26) and UGT1A128 (OR = 0.80, p = 0.54) and the prevalence of UGT1A128/6 diplotypes did not differ significantly from those in the control population. No UGT1A127 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A128/6/27 genotypes or UGT1A128/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.
doi_str_mv	10.1007/s10803-021-04941-w
format	Article
fullrecord	<record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2502807387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A691808304</galeid><ericid>EJ1327237</ericid><sourcerecordid>A691808304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c602t-6c336d53a8813d31f69d8b440ff9b1d40abfdfbd369026e8d29393311d3d2a5d3</originalsourceid><addsrcrecordid>eNp9kt1uEzEQhVcIREvhBZBAlriBiy22Z7M_l1HahlYVVG1zvfLas4nLrh1sLyVvxuPhJKVVUIQs2ZbnO2ek8UmSt4weM0qLz57RkkJKOUtpVmUsvX-WHLJRASlkwJ8nh5TlPAU-Kg6SV97fUUqrkvOXyQFAARQ4O0x-T9Fg0JKMjehWXntiWzKb3rIxI1e2W_XWLRfa957MvDZzcuXQo_uJipw4HfdZ3-hOS9GRiXWKtNaRsffoN3BYYDQJaIKOQDT-itaIEO8XYjBKSyTCE0Gutf9OzoQMUb1xGEJsSW6WKIMbenKifTRHR7Qhk4XulEPzOnnRis7jm4fzKJmdnd5OvqSX36bnk_FlKnPKQ5pLgFyNQJQlAwWszStVNllG27ZqmMqoaFrVNgryivIcS8UrqAAYU6C4GCk4Sj5ufZfO_hjQh7rXXmLXCYN28DUfUV7SAsoioh_-Qe_s4OJcI5XzEeMZ5PyJmosOa21aG5yQa9N6nFespCXQLFLpHmoeP8uJzhpsdXze4Y_38HEp7LXcK_i0I4hMwF9hLgbv6_Ob612Wb1nprPcO23rpdC_cqma0Xkex3kaxjlGsN1Gs76Po_cM0hqZH9Sj5m70IvNsC6LR8LJ9eMOAFh_U4YVv3sWbm6J7G-Z-2fwA8DfFU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2625124362</pqid></control><display><type>article</type><title>Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Education Source</source><source>Springer Nature - Complete Springer Journals</source><creator>Horinouchi, Tomoko ; Maeyama, Kaori ; Nagai, Masashi ; Mizobuchi, Masami ; Takagi, Yasuko ; Okada, Yuka ; Kato, Takeshi ; Nishimura, Mio ; Kawasaki, Yoko ; Yoshioka, Mieko ; Takada, Satoshi ; Matsumoto, Hisayuki ; Nakamachi, Yuji ; Saegusa, Jun ; Fukushima, Sachiyo ; Fujioka, Kazumichi ; Tomioka, Kazumi ; Nagase, Hiroaki ; Nozu, Kandai ; Iijima, Kazumoto ; Nishimura, Noriyuki</creator><creatorcontrib>Horinouchi, Tomoko ; Maeyama, Kaori ; Nagai, Masashi ; Mizobuchi, Masami ; Takagi, Yasuko ; Okada, Yuka ; Kato, Takeshi ; Nishimura, Mio ; Kawasaki, Yoko ; Yoshioka, Mieko ; Takada, Satoshi ; Matsumoto, Hisayuki ; Nakamachi, Yuji ; Saegusa, Jun ; Fukushima, Sachiyo ; Fujioka, Kazumichi ; Tomioka, Kazumi ; Nagase, Hiroaki ; Nozu, Kandai ; Iijima, Kazumoto ; Nishimura, Noriyuki</creatorcontrib><description>Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A128 (c.-41-40dup) , UGT1A16 (c.211 G > A), and UGT1A127 (c.686 C > A). The allele frequency of UGT1A16 (OR = 1.34, p = 0.26) and UGT1A128 (OR = 0.80, p = 0.54) and the prevalence of UGT1A128/6 diplotypes did not differ significantly from those in the control population. No UGT1A127 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A128/6/27 genotypes or UGT1A128/6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.</description><identifier>ISSN: 0162-3257</identifier><identifier>EISSN: 1573-3432</identifier><identifier>DOI: 10.1007/s10803-021-04941-w</identifier><identifier>PMID: 33730321</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alleles ; At Risk Persons ; Autism ; Autism Spectrum Disorder - diagnosis ; Autism Spectrum Disorder - genetics ; Autistic children ; Behavioral Science and Psychology ; Biochemistry ; Child ; Child and School Psychology ; Children ; Complications and side effects ; Composition ; Deoxyribonucleic acid ; DNA ; Female ; Gene frequency ; Genetic analysis ; Genetic polymorphisms ; Genotypes ; Glucuronosyltransferase - genetics ; Health aspects ; Humans ; Infant, Newborn ; Jaundice ; Jaundice, Neonatal - complications ; Neonatal jaundice ; Neonates ; Neurosciences ; Newborn babies ; Original Paper ; Pediatric research ; Pediatrics ; Perinatal ; Pervasive Developmental Disorders ; Physiology ; Polymorphism, Genetic ; Population genetics ; Pregnancy ; Protection and preservation ; Psychology ; Public Health ; Risk Factors ; Symptoms (Individual Disorders) ; Tissues ; Umbilical Cord</subject><ispartof>Journal of autism and developmental disorders, 2022-02, Vol.52 (2), p.483-489</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-6c336d53a8813d31f69d8b440ff9b1d40abfdfbd369026e8d29393311d3d2a5d3</citedby><cites>FETCH-LOGICAL-c602t-6c336d53a8813d31f69d8b440ff9b1d40abfdfbd369026e8d29393311d3d2a5d3</cites><orcidid>0000-0002-9000-4341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10803-021-04941-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10803-021-04941-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,12826,27903,27904,30978,41467,42536,51298</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ1327237$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33730321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horinouchi, Tomoko</creatorcontrib><creatorcontrib>Maeyama, Kaori</creatorcontrib><creatorcontrib>Nagai, Masashi</creatorcontrib><creatorcontrib>Mizobuchi, Masami</creatorcontrib><creatorcontrib>Takagi, Yasuko</creatorcontrib><creatorcontrib>Okada, Yuka</creatorcontrib><creatorcontrib>Kato, Takeshi</creatorcontrib><creatorcontrib>Nishimura, Mio</creatorcontrib><creatorcontrib>Kawasaki, Yoko</creatorcontrib><creatorcontrib>Yoshioka, Mieko</creatorcontrib><creatorcontrib>Takada, Satoshi</creatorcontrib><creatorcontrib>Matsumoto, Hisayuki</creatorcontrib><creatorcontrib>Nakamachi, Yuji</creatorcontrib><creatorcontrib>Saegusa, Jun</creatorcontrib><creatorcontrib>Fukushima, Sachiyo</creatorcontrib><creatorcontrib>Fujioka, Kazumichi</creatorcontrib><creatorcontrib>Tomioka, Kazumi</creatorcontrib><creatorcontrib>Nagase, Hiroaki</creatorcontrib><creatorcontrib>Nozu, Kandai</creatorcontrib><creatorcontrib>Iijima, Kazumoto</creatorcontrib><creatorcontrib>Nishimura, Noriyuki</creatorcontrib><title>Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children</title><title>Journal of autism and developmental disorders</title><addtitle>J Autism Dev Disord</addtitle><addtitle>J Autism Dev Disord</addtitle><description>Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A128 (c.-41-40dup) , UGT1A16 (c.211 G > A), and UGT1A127 (c.686 C > A). The allele frequency of UGT1A16 (OR = 1.34, p = 0.26) and UGT1A128 (OR = 0.80, p = 0.54) and the prevalence of UGT1A128/6 diplotypes did not differ significantly from those in the control population. No UGT1A127 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A128/6/27 genotypes or UGT1A128/6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.</description><subject>Alleles</subject><subject>At Risk Persons</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - diagnosis</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Autistic children</subject><subject>Behavioral Science and Psychology</subject><subject>Biochemistry</subject><subject>Child</subject><subject>Child and School Psychology</subject><subject>Children</subject><subject>Complications and side effects</subject><subject>Composition</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Gene frequency</subject><subject>Genetic analysis</subject><subject>Genetic polymorphisms</subject><subject>Genotypes</subject><subject>Glucuronosyltransferase - genetics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Jaundice</subject><subject>Jaundice, Neonatal - complications</subject><subject>Neonatal jaundice</subject><subject>Neonates</subject><subject>Neurosciences</subject><subject>Newborn babies</subject><subject>Original Paper</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Perinatal</subject><subject>Pervasive Developmental Disorders</subject><subject>Physiology</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Pregnancy</subject><subject>Protection and preservation</subject><subject>Psychology</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Symptoms (Individual Disorders)</subject><subject>Tissues</subject><subject>Umbilical Cord</subject><issn>0162-3257</issn><issn>1573-3432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kt1uEzEQhVcIREvhBZBAlriBiy22Z7M_l1HahlYVVG1zvfLas4nLrh1sLyVvxuPhJKVVUIQs2ZbnO2ek8UmSt4weM0qLz57RkkJKOUtpVmUsvX-WHLJRASlkwJ8nh5TlPAU-Kg6SV97fUUqrkvOXyQFAARQ4O0x-T9Fg0JKMjehWXntiWzKb3rIxI1e2W_XWLRfa957MvDZzcuXQo_uJipw4HfdZ3-hOS9GRiXWKtNaRsffoN3BYYDQJaIKOQDT-itaIEO8XYjBKSyTCE0Gutf9OzoQMUb1xGEJsSW6WKIMbenKifTRHR7Qhk4XulEPzOnnRis7jm4fzKJmdnd5OvqSX36bnk_FlKnPKQ5pLgFyNQJQlAwWszStVNllG27ZqmMqoaFrVNgryivIcS8UrqAAYU6C4GCk4Sj5ufZfO_hjQh7rXXmLXCYN28DUfUV7SAsoioh_-Qe_s4OJcI5XzEeMZ5PyJmosOa21aG5yQa9N6nFespCXQLFLpHmoeP8uJzhpsdXze4Y_38HEp7LXcK_i0I4hMwF9hLgbv6_Ob612Wb1nprPcO23rpdC_cqma0Xkex3kaxjlGsN1Gs76Po_cM0hqZH9Sj5m70IvNsC6LR8LJ9eMOAFh_U4YVv3sWbm6J7G-Z-2fwA8DfFU</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Horinouchi, Tomoko</creator><creator>Maeyama, Kaori</creator><creator>Nagai, Masashi</creator><creator>Mizobuchi, Masami</creator><creator>Takagi, Yasuko</creator><creator>Okada, Yuka</creator><creator>Kato, Takeshi</creator><creator>Nishimura, Mio</creator><creator>Kawasaki, Yoko</creator><creator>Yoshioka, Mieko</creator><creator>Takada, Satoshi</creator><creator>Matsumoto, Hisayuki</creator><creator>Nakamachi, Yuji</creator><creator>Saegusa, Jun</creator><creator>Fukushima, Sachiyo</creator><creator>Fujioka, Kazumichi</creator><creator>Tomioka, Kazumi</creator><creator>Nagase, Hiroaki</creator><creator>Nozu, Kandai</creator><creator>Iijima, Kazumoto</creator><creator>Nishimura, Noriyuki</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8A4</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9000-4341</orcidid></search><sort><creationdate>20220201</creationdate><title>Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children</title><author>Horinouchi, Tomoko ; Maeyama, Kaori ; Nagai, Masashi ; Mizobuchi, Masami ; Takagi, Yasuko ; Okada, Yuka ; Kato, Takeshi ; Nishimura, Mio ; Kawasaki, Yoko ; Yoshioka, Mieko ; Takada, Satoshi ; Matsumoto, Hisayuki ; Nakamachi, Yuji ; Saegusa, Jun ; Fukushima, Sachiyo ; Fujioka, Kazumichi ; Tomioka, Kazumi ; Nagase, Hiroaki ; Nozu, Kandai ; Iijima, Kazumoto ; Nishimura, Noriyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-6c336d53a8813d31f69d8b440ff9b1d40abfdfbd369026e8d29393311d3d2a5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alleles</topic><topic>At Risk Persons</topic><topic>Autism</topic><topic>Autism Spectrum Disorder - diagnosis</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Autistic children</topic><topic>Behavioral Science and Psychology</topic><topic>Biochemistry</topic><topic>Child</topic><topic>Child and School Psychology</topic><topic>Children</topic><topic>Complications and side effects</topic><topic>Composition</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Gene frequency</topic><topic>Genetic analysis</topic><topic>Genetic polymorphisms</topic><topic>Genotypes</topic><topic>Glucuronosyltransferase - genetics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Jaundice</topic><topic>Jaundice, Neonatal - complications</topic><topic>Neonatal jaundice</topic><topic>Neonates</topic><topic>Neurosciences</topic><topic>Newborn babies</topic><topic>Original Paper</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Perinatal</topic><topic>Pervasive Developmental Disorders</topic><topic>Physiology</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Pregnancy</topic><topic>Protection and preservation</topic><topic>Psychology</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Symptoms (Individual Disorders)</topic><topic>Tissues</topic><topic>Umbilical Cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horinouchi, Tomoko</creatorcontrib><creatorcontrib>Maeyama, Kaori</creatorcontrib><creatorcontrib>Nagai, Masashi</creatorcontrib><creatorcontrib>Mizobuchi, Masami</creatorcontrib><creatorcontrib>Takagi, Yasuko</creatorcontrib><creatorcontrib>Okada, Yuka</creatorcontrib><creatorcontrib>Kato, Takeshi</creatorcontrib><creatorcontrib>Nishimura, Mio</creatorcontrib><creatorcontrib>Kawasaki, Yoko</creatorcontrib><creatorcontrib>Yoshioka, Mieko</creatorcontrib><creatorcontrib>Takada, Satoshi</creatorcontrib><creatorcontrib>Matsumoto, Hisayuki</creatorcontrib><creatorcontrib>Nakamachi, Yuji</creatorcontrib><creatorcontrib>Saegusa, Jun</creatorcontrib><creatorcontrib>Fukushima, Sachiyo</creatorcontrib><creatorcontrib>Fujioka, Kazumichi</creatorcontrib><creatorcontrib>Tomioka, Kazumi</creatorcontrib><creatorcontrib>Nagase, Hiroaki</creatorcontrib><creatorcontrib>Nozu, Kandai</creatorcontrib><creatorcontrib>Iijima, Kazumoto</creatorcontrib><creatorcontrib>Nishimura, Noriyuki</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of autism and developmental disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horinouchi, Tomoko</au><au>Maeyama, Kaori</au><au>Nagai, Masashi</au><au>Mizobuchi, Masami</au><au>Takagi, Yasuko</au><au>Okada, Yuka</au><au>Kato, Takeshi</au><au>Nishimura, Mio</au><au>Kawasaki, Yoko</au><au>Yoshioka, Mieko</au><au>Takada, Satoshi</au><au>Matsumoto, Hisayuki</au><au>Nakamachi, Yuji</au><au>Saegusa, Jun</au><au>Fukushima, Sachiyo</au><au>Fujioka, Kazumichi</au><au>Tomioka, Kazumi</au><au>Nagase, Hiroaki</au><au>Nozu, Kandai</au><au>Iijima, Kazumoto</au><au>Nishimura, Noriyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ1327237</ericid><atitle>Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children</atitle><jtitle>Journal of autism and developmental disorders</jtitle><stitle>J Autism Dev Disord</stitle><addtitle>J Autism Dev Disord</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>52</volume><issue>2</issue><spage>483</spage><epage>489</epage><pages>483-489</pages><issn>0162-3257</issn><eissn>1573-3432</eissn><abstract>Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A128 (c.-41-40dup) , UGT1A16 (c.211 G > A), and UGT1A127 (c.686 C > A). The allele frequency of UGT1A16 (OR = 1.34, p = 0.26) and UGT1A128 (OR = 0.80, p = 0.54) and the prevalence of UGT1A128/6 diplotypes did not differ significantly from those in the control population. No UGT1A127 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A128/6/27 genotypes or UGT1A128/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33730321</pmid><doi>10.1007/s10803-021-04941-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9000-4341</orcidid></addata></record>
fulltext	fulltext
identifier	ISSN: 0162-3257
ispartof	Journal of autism and developmental disorders, 2022-02, Vol.52 (2), p.483-489
issn	0162-3257 1573-3432
language	eng
recordid	cdi_proquest_miscellaneous_2502807387
source	MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Education Source; Springer Nature - Complete Springer Journals
subjects	Alleles At Risk Persons Autism Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Autistic children Behavioral Science and Psychology Biochemistry Child Child and School Psychology Children Complications and side effects Composition Deoxyribonucleic acid DNA Female Gene frequency Genetic analysis Genetic polymorphisms Genotypes Glucuronosyltransferase - genetics Health aspects Humans Infant, Newborn Jaundice Jaundice, Neonatal - complications Neonatal jaundice Neonates Neurosciences Newborn babies Original Paper Pediatric research Pediatrics Perinatal Pervasive Developmental Disorders Physiology Polymorphism, Genetic Population genetics Pregnancy Protection and preservation Psychology Public Health Risk Factors Symptoms (Individual Disorders) Tissues Umbilical Cord
title	Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T01%3A57%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Analysis%20of%20UGT1A1%20Polymorphisms%20Using%20Preserved%20Dried%20Umbilical%20Cord%20for%20Assessing%20the%20Potential%20of%20Neonatal%20Jaundice%20as%20a%20Risk%20Factor%20for%20Autism%20Spectrum%20Disorder%20in%20Children&rft.jtitle=Journal%20of%20autism%20and%20developmental%20disorders&rft.au=Horinouchi,%20Tomoko&rft.date=2022-02-01&rft.volume=52&rft.issue=2&rft.spage=483&rft.epage=489&rft.pages=483-489&rft.issn=0162-3257&rft.eissn=1573-3432&rft_id=info:doi/10.1007/s10803-021-04941-w&rft_dat=%3Cgale_proqu%3EA691808304%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2625124362&rft_id=info:pmid/33730321&rft_galeid=A691808304&rft_ericid=EJ1327237&rfr_iscdi=true