One-Pot In Vitro Ribosomal Synthesis of Macrocyclic Depsipeptides

Here, we report a method for the one-pot ribosomal synthesis of macrocyclic depsipeptides. This method is based on a Ser-Pro-Cys-Gly (SPCG) motif discovered by in vitro selection of peptides for the function of self-acylation in the presence of a thioester acyl donor, which forms an O-acyl isopeptid...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-03, Vol.143 (12), p.4741-4750
Hauptverfasser:	Nagano, Masanobu, Huang, Yichao, Obexer, Richard, Suga, Hiroaki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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