Effect of fluid resuscitation on acute lung injury in a rat model of sepsis
Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fluid therapy on ARDS caused by seps...
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| Veröffentlicht in: | Bratislava Medical Journal 2021, Vol.122 (4), p.280-286 |
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| creator | Erdogan, A Erdogan, M A Kara, A Y Bora, S Yigitturk, G Erbas, O |
| description | Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fluid therapy on ARDS caused by sepsis.
To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO2 were measured.
The scores of all histological parameters of the group treated with hypertonic saline were significantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO2 was significantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO2 was significantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of inflammatory markers were also significantly lower in hypertonic saline groups compared to other groups (p < 0.001).
Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab. 3, Fig. 4, Ref. 49). |
| doi_str_mv | 10.4149/BLL_2021_047 |
| format | Article |
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To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO2 were measured.
The scores of all histological parameters of the group treated with hypertonic saline were significantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO2 was significantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO2 was significantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of inflammatory markers were also significantly lower in hypertonic saline groups compared to other groups (p < 0.001).
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To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO2 were measured.
The scores of all histological parameters of the group treated with hypertonic saline were significantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO2 was significantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO2 was significantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of inflammatory markers were also significantly lower in hypertonic saline groups compared to other groups (p < 0.001).
Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab. 3, Fig. 4, Ref. 49).</description><subject>Acute Lung Injury - drug therapy</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Fluid Therapy</subject><subject>Lung</subject><subject>Rats</subject><subject>Saline Solution, Hypertonic - therapeutic use</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - therapy</subject><subject>Tumor Necrosis Factor-alpha</subject><issn>0006-9248</issn><issn>1336-0345</issn><issn>1336-0345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAUhS0EoqWwMSOPDASu7dhJRqjKQ0Rigdly3GvkKo9ix0P_PakoCOlIZ_nOGT5CLhnc5iyv7h7qWnPgTENeHJE5E0JlIHJ5TOYAoLKK5-WMnMW4AciFZOqUzIQoeFVyPievK-fQjnRw1LXJr2nAmKL1oxn90NMpxqYRaZv6T-r7TQq7qaihwYy0G9bY7qcRt9HHc3LiTBvx4tAL8vG4el8-Z_Xb08vyvs6s4NWYcWsRVSMF8pIVTqrGNKzCxgHLbVlI6RwzHBxHUEZVqATYqjHWSmUnrhALcv3zuw3DV8I46s5Hi21rehxS1FwCL0EqsUdvflAbhhgDOr0NvjNhpxnovT79X9-EXx2eU9Ph-g_-9SW-AaGCasU</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Erdogan, A</creator><creator>Erdogan, M A</creator><creator>Kara, A Y</creator><creator>Bora, S</creator><creator>Yigitturk, G</creator><creator>Erbas, O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2021</creationdate><title>Effect of fluid resuscitation on acute lung injury in a rat model of sepsis</title><author>Erdogan, A ; Erdogan, M A ; Kara, A Y ; Bora, S ; Yigitturk, G ; Erbas, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-2ccee6b53e2817f56bab19ebf014c8755ff1a20f2e06a69e630c9bacc56c19e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Lung Injury - drug therapy</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Fluid Therapy</topic><topic>Lung</topic><topic>Rats</topic><topic>Saline Solution, Hypertonic - therapeutic use</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis - therapy</topic><topic>Tumor Necrosis Factor-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdogan, A</creatorcontrib><creatorcontrib>Erdogan, M A</creatorcontrib><creatorcontrib>Kara, A Y</creatorcontrib><creatorcontrib>Bora, S</creatorcontrib><creatorcontrib>Yigitturk, G</creatorcontrib><creatorcontrib>Erbas, O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bratislava Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdogan, A</au><au>Erdogan, M A</au><au>Kara, A Y</au><au>Bora, S</au><au>Yigitturk, G</au><au>Erbas, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of fluid resuscitation on acute lung injury in a rat model of sepsis</atitle><jtitle>Bratislava Medical Journal</jtitle><addtitle>Bratisl Lek Listy</addtitle><date>2021</date><risdate>2021</risdate><volume>122</volume><issue>4</issue><spage>280</spage><epage>286</epage><pages>280-286</pages><issn>0006-9248</issn><issn>1336-0345</issn><eissn>1336-0345</eissn><abstract>Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fluid therapy on ARDS caused by sepsis.
To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO2 were measured.
The scores of all histological parameters of the group treated with hypertonic saline were significantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO2 was significantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO2 was significantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of inflammatory markers were also significantly lower in hypertonic saline groups compared to other groups (p < 0.001).
Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab. 3, Fig. 4, Ref. 49).</abstract><cop>Slovakia</cop><pmid>33729822</pmid><doi>10.4149/BLL_2021_047</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Lung Injury - drug therapy Animals Disease Models, Animal Fluid Therapy Lung Rats Saline Solution, Hypertonic - therapeutic use Sepsis - drug therapy Sepsis - therapy Tumor Necrosis Factor-alpha |
| title | Effect of fluid resuscitation on acute lung injury in a rat model of sepsis |
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