Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study
Purpose Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with n...
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| Veröffentlicht in: | Pituitary 2021-08, Vol.24 (4), p.600-610 |
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| creator | Hacioglu, Aysa Gundogdu, Aycan Nalbantoglu, Ufuk Karaca, Zuleyha Urhan, Muhammed Emre Sahin, Serdar Dokmetas, Hatice Sebile Kadioglu, Pinar Kelestimur, Fahrettin |
| description | Purpose
Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.
Method
Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.
Results
Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly.
Bifidobacterium
,
Collinsella
,
Bacteroides
,
Butyricimonas
,
Clostridium
,
Oscillospira
, and
Dialister
were predominating in the control group.
Conclusion
The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations. |
| doi_str_mv | 10.1007/s11102-021-01137-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2501852958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2501852958</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-cb38fed4f2552d42907afb88acebfd5138786f66737cba7ae6a1a7fc74b3c0e13</originalsourceid><addsrcrecordid>eNp9kEtLAzEYRYMotj7-gAsJuHETzZfHZOpOii8ouFHQVchkMjVlHnWSQfrvjW1VcOEqITn3Jt9B6AToBVCqLgMAUEYoA0IBuCJiB41BKk6UoHw37XmeES7gZYQOQlhQmmJc7KMR54oBKDlGr3dDxI23fVf4LhrsW7w00bs2Bvzh4xtu3Ue9wqU387YLrsQmoY2bm3p1hQ1e-rqLOB2FQIKz0XetqXGIQ7k6QnuVqYM73q6H6Pn25ml6T2aPdw_T6xmxXMlIbMHzypWiYlKyUrAJVaYq8txYV1SlTCOoPKuyTHFlC6OMywwYVVklCm6pA36Izje9y757H1yIuvHBuro2reuGoJmkkEs2kXlCz_6gi27o04-_KDHJ-QQymii2odZj9a7Sy943pl9poPpLvN6I10m8XovXIoVOt9VD0bjyJ_JtOgF8A4R01c5d__v2P7WfeZyO0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2549839160</pqid></control><display><type>article</type><title>Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Hacioglu, Aysa ; Gundogdu, Aycan ; Nalbantoglu, Ufuk ; Karaca, Zuleyha ; Urhan, Muhammed Emre ; Sahin, Serdar ; Dokmetas, Hatice Sebile ; Kadioglu, Pinar ; Kelestimur, Fahrettin</creator><creatorcontrib>Hacioglu, Aysa ; Gundogdu, Aycan ; Nalbantoglu, Ufuk ; Karaca, Zuleyha ; Urhan, Muhammed Emre ; Sahin, Serdar ; Dokmetas, Hatice Sebile ; Kadioglu, Pinar ; Kelestimur, Fahrettin ; Pituitary Microbiom Study Group (PITMIT-SG)</creatorcontrib><description>Purpose
Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.
Method
Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.
Results
Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly.
Bifidobacterium
,
Collinsella
,
Bacteroides
,
Butyricimonas
,
Clostridium
,
Oscillospira
, and
Dialister
were predominating in the control group.
Conclusion
The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-021-01137-4</identifier><identifier>PMID: 33721175</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acromegaly ; Bacteroidetes ; Body mass index ; Cross-sectional studies ; Endocrinology ; Human Physiology ; Intestinal microflora ; Medicine ; Medicine & Public Health ; Microbiota ; Patients ; Well being</subject><ispartof>Pituitary, 2021-08, Vol.24 (4), p.600-610</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cb38fed4f2552d42907afb88acebfd5138786f66737cba7ae6a1a7fc74b3c0e13</citedby><cites>FETCH-LOGICAL-c375t-cb38fed4f2552d42907afb88acebfd5138786f66737cba7ae6a1a7fc74b3c0e13</cites><orcidid>0000-0002-2861-4683</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-021-01137-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-021-01137-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33721175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hacioglu, Aysa</creatorcontrib><creatorcontrib>Gundogdu, Aycan</creatorcontrib><creatorcontrib>Nalbantoglu, Ufuk</creatorcontrib><creatorcontrib>Karaca, Zuleyha</creatorcontrib><creatorcontrib>Urhan, Muhammed Emre</creatorcontrib><creatorcontrib>Sahin, Serdar</creatorcontrib><creatorcontrib>Dokmetas, Hatice Sebile</creatorcontrib><creatorcontrib>Kadioglu, Pinar</creatorcontrib><creatorcontrib>Kelestimur, Fahrettin</creatorcontrib><creatorcontrib>Pituitary Microbiom Study Group (PITMIT-SG)</creatorcontrib><title>Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Purpose
Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.
Method
Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.
Results
Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly.
Bifidobacterium
,
Collinsella
,
Bacteroides
,
Butyricimonas
,
Clostridium
,
Oscillospira
, and
Dialister
were predominating in the control group.
Conclusion
The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.</description><subject>Acromegaly</subject><subject>Bacteroidetes</subject><subject>Body mass index</subject><subject>Cross-sectional studies</subject><subject>Endocrinology</subject><subject>Human Physiology</subject><subject>Intestinal microflora</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbiota</subject><subject>Patients</subject><subject>Well being</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtLAzEYRYMotj7-gAsJuHETzZfHZOpOii8ouFHQVchkMjVlHnWSQfrvjW1VcOEqITn3Jt9B6AToBVCqLgMAUEYoA0IBuCJiB41BKk6UoHw37XmeES7gZYQOQlhQmmJc7KMR54oBKDlGr3dDxI23fVf4LhrsW7w00bs2Bvzh4xtu3Ue9wqU387YLrsQmoY2bm3p1hQ1e-rqLOB2FQIKz0XetqXGIQ7k6QnuVqYM73q6H6Pn25ml6T2aPdw_T6xmxXMlIbMHzypWiYlKyUrAJVaYq8txYV1SlTCOoPKuyTHFlC6OMywwYVVklCm6pA36Izje9y757H1yIuvHBuro2reuGoJmkkEs2kXlCz_6gi27o04-_KDHJ-QQymii2odZj9a7Sy943pl9poPpLvN6I10m8XovXIoVOt9VD0bjyJ_JtOgF8A4R01c5d__v2P7WfeZyO0g</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Hacioglu, Aysa</creator><creator>Gundogdu, Aycan</creator><creator>Nalbantoglu, Ufuk</creator><creator>Karaca, Zuleyha</creator><creator>Urhan, Muhammed Emre</creator><creator>Sahin, Serdar</creator><creator>Dokmetas, Hatice Sebile</creator><creator>Kadioglu, Pinar</creator><creator>Kelestimur, Fahrettin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2861-4683</orcidid></search><sort><creationdate>20210801</creationdate><title>Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study</title><author>Hacioglu, Aysa ; Gundogdu, Aycan ; Nalbantoglu, Ufuk ; Karaca, Zuleyha ; Urhan, Muhammed Emre ; Sahin, Serdar ; Dokmetas, Hatice Sebile ; Kadioglu, Pinar ; Kelestimur, Fahrettin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cb38fed4f2552d42907afb88acebfd5138786f66737cba7ae6a1a7fc74b3c0e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acromegaly</topic><topic>Bacteroidetes</topic><topic>Body mass index</topic><topic>Cross-sectional studies</topic><topic>Endocrinology</topic><topic>Human Physiology</topic><topic>Intestinal microflora</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbiota</topic><topic>Patients</topic><topic>Well being</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hacioglu, Aysa</creatorcontrib><creatorcontrib>Gundogdu, Aycan</creatorcontrib><creatorcontrib>Nalbantoglu, Ufuk</creatorcontrib><creatorcontrib>Karaca, Zuleyha</creatorcontrib><creatorcontrib>Urhan, Muhammed Emre</creatorcontrib><creatorcontrib>Sahin, Serdar</creatorcontrib><creatorcontrib>Dokmetas, Hatice Sebile</creatorcontrib><creatorcontrib>Kadioglu, Pinar</creatorcontrib><creatorcontrib>Kelestimur, Fahrettin</creatorcontrib><creatorcontrib>Pituitary Microbiom Study Group (PITMIT-SG)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hacioglu, Aysa</au><au>Gundogdu, Aycan</au><au>Nalbantoglu, Ufuk</au><au>Karaca, Zuleyha</au><au>Urhan, Muhammed Emre</au><au>Sahin, Serdar</au><au>Dokmetas, Hatice Sebile</au><au>Kadioglu, Pinar</au><au>Kelestimur, Fahrettin</au><aucorp>Pituitary Microbiom Study Group (PITMIT-SG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>24</volume><issue>4</issue><spage>600</spage><epage>610</epage><pages>600-610</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Purpose
Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.
Method
Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.
Results
Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly.
Bifidobacterium
,
Collinsella
,
Bacteroides
,
Butyricimonas
,
Clostridium
,
Oscillospira
, and
Dialister
were predominating in the control group.
Conclusion
The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33721175</pmid><doi>10.1007/s11102-021-01137-4</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2861-4683</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-341X |
| ispartof | Pituitary, 2021-08, Vol.24 (4), p.600-610 |
| issn | 1386-341X 1573-7403 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acromegaly Bacteroidetes Body mass index Cross-sectional studies Endocrinology Human Physiology Intestinal microflora Medicine Medicine & Public Health Microbiota Patients Well being |
| title | Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study |
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