Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 68

Treatment of hepatocellular carcinoma (HCC) is currently challenging. Cancer-associated fibroblasts (CAFs) promote the malignancy of HCC cells via production of cytokines. Conophylline (CnP), a vinca alkaloid obtained from leaves, has been reported to suppress activation of hepatic stellate cells an...

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Veröffentlicht in:	Molecular cancer therapeutics 2021-06, Vol.20 (6), p.1019-1028
Hauptverfasser:	Yamanaka, Takahiro, Harimoto, Norifumi, Yokobori, Takehiko, Muranushi, Ryo, Hoshino, Kouki, Hagiwara, Kei, Gantumur, Dolgormaa, Handa, Tadashi, Ishii, Norihiro, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Umezawa, Kazuo, Shirabe, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer-Associated Fibroblasts - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Mice Receptors, G-Protein-Coupled - metabolism Vinca Alkaloids - pharmacology Vinca Alkaloids - therapeutic use
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