Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020)
Objectives To review the clinical findings and outcome in dogs diagnosed with insulinoma, and to assess which factors are predictors of overall survival. Additionally, to describe the neurological manifestations of this population and their correlation with survival. Materials and Methods Retrospect...
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| Veröffentlicht in: | Journal of small animal practice 2021-07, Vol.62 (7), p.531-539 |
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| container_title | Journal of small animal practice |
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| creator | Ryan, D. Pérez‐Accino, J. Gonçalves, R. Czopowicz, M. Bertolani, C. Tabar, M. D. Puig, J. Ros, C. Suñol, A. |
| description | Objectives
To review the clinical findings and outcome in dogs diagnosed with insulinoma, and to assess which factors are predictors of overall survival. Additionally, to describe the neurological manifestations of this population and their correlation with survival.
Materials and Methods
Retrospective multicentric study of canine insulinoma cases (2009 to 2020). Signalment, clinical history, neurological examination, diagnostic findings, treatment and outcome were obtained from clinical records. Univariate and multivariate analyses were used to compare the overall survival.
Results
One hundred and sixteen cases were included. Median duration of clinical signs before presentation was 1.5 months. The most common presenting clinical signs were weakness (59.5%), epileptic seizures (33.6%) and changes in consciousness or behaviour (27.6%). Three dogs were suspected to have paroxysmal dyskinesia. Thirty‐two dogs had an abnormal neurological examination, most commonly showing obtundation (28.1%), decreased withdrawal reflexes (21.9%) and absent menace response (18.8%). Overall survival for dogs undergoing surgery (20 months) was significantly longer than in medically treated (8 months; adjusted hazard ratio: 0.33; 95% confidence interval: 0.18, 0.59). Presence of metastases was the only other variable associated with prognosis (adjusted hazard ratio 1.72; 95% confidence interval: 1.02, 2.91).
Clinical Significance
Clinical signs of canine insulinoma are vague and non‐specific. Weakness, epileptic seizures and changes in mentation or behaviour were the most commonly reported. Obtunded mentation and forebrain neurolocalisation were the main neurological manifestations. Dogs undergoing surgery had a longer overall survival compared to medically treated cases, and dogs with metastasis had a shorter overall survival regardless of treatment modality. Abnormalities in the neurological examination did not correlate with prognosis. |
| doi_str_mv | 10.1111/jsap.13318 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2501850964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2551572267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3938-a33e142716fceeff8f1be75786f32ec993c7bc4512433e3e82a5e8dcfd3ef8a33</originalsourceid><addsrcrecordid>eNp9kUtOwzAQhi0EglLYcABkiQ0gAn4kscMOVTyFBBKwjlxnXFwldombInYcgSNwFo7CSTAUWLDAm5E9nz-N_SO0Qck-jetgHNRkn3JO5QLqUZHKJJNMLKIeIYwlaUbJCloNYRy3eSrIMlrhXLA0LfIeaga1dVarGhvrKutGYQ876Fpf-9HXcaOcNRCmamq9C1i5CoeundlZ7HmDKz8K-NFO799erQtdlPlGHWJKc6xVgIC3GSHF-_MLI4zsrKElo-oA69-1j-5Ojm8HZ8nl1en54Ogy0bzgMlGcA02ZoLnRAMZIQ4cgMiFzwxnoouBaDHV8GEsjyUEylYGstKk4GBlv99H23Dtp_UMXpy8bGzTUtXLgu1CyjFCZkSJPI7r1Bx37rnVxukhlNBOM5SJSu3NKtz6EFkw5aW2j2qeSkvIzhPIzhPIrhAhvfiu7YQPVL_rz6xGgc-DR1vD0j6q8uDm6nks_AAbfkkc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2551572267</pqid></control><display><type>article</type><title>Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020)</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Ryan, D. ; Pérez‐Accino, J. ; Gonçalves, R. ; Czopowicz, M. ; Bertolani, C. ; Tabar, M. D. ; Puig, J. ; Ros, C. ; Suñol, A.</creator><creatorcontrib>Ryan, D. ; Pérez‐Accino, J. ; Gonçalves, R. ; Czopowicz, M. ; Bertolani, C. ; Tabar, M. D. ; Puig, J. ; Ros, C. ; Suñol, A.</creatorcontrib><description>Objectives
To review the clinical findings and outcome in dogs diagnosed with insulinoma, and to assess which factors are predictors of overall survival. Additionally, to describe the neurological manifestations of this population and their correlation with survival.
Materials and Methods
Retrospective multicentric study of canine insulinoma cases (2009 to 2020). Signalment, clinical history, neurological examination, diagnostic findings, treatment and outcome were obtained from clinical records. Univariate and multivariate analyses were used to compare the overall survival.
Results
One hundred and sixteen cases were included. Median duration of clinical signs before presentation was 1.5 months. The most common presenting clinical signs were weakness (59.5%), epileptic seizures (33.6%) and changes in consciousness or behaviour (27.6%). Three dogs were suspected to have paroxysmal dyskinesia. Thirty‐two dogs had an abnormal neurological examination, most commonly showing obtundation (28.1%), decreased withdrawal reflexes (21.9%) and absent menace response (18.8%). Overall survival for dogs undergoing surgery (20 months) was significantly longer than in medically treated (8 months; adjusted hazard ratio: 0.33; 95% confidence interval: 0.18, 0.59). Presence of metastases was the only other variable associated with prognosis (adjusted hazard ratio 1.72; 95% confidence interval: 1.02, 2.91).
Clinical Significance
Clinical signs of canine insulinoma are vague and non‐specific. Weakness, epileptic seizures and changes in mentation or behaviour were the most commonly reported. Obtunded mentation and forebrain neurolocalisation were the main neurological manifestations. Dogs undergoing surgery had a longer overall survival compared to medically treated cases, and dogs with metastasis had a shorter overall survival regardless of treatment modality. Abnormalities in the neurological examination did not correlate with prognosis.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/jsap.13318</identifier><identifier>PMID: 33724496</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Confidence intervals ; Convulsions & seizures ; Dog Diseases - diagnosis ; Dogs ; Dyskinesia ; Epilepsy ; Forebrain ; Insulinoma ; Insulinoma - veterinary ; Medical prognosis ; Metastases ; Neuroendocrine tumors ; Pancreatic Neoplasms - veterinary ; Prognosis ; Reflexes ; Retrospective Studies ; Seizures ; Seizures - veterinary ; Surgery ; Survival</subject><ispartof>Journal of small animal practice, 2021-07, Vol.62 (7), p.531-539</ispartof><rights>2021 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association</rights><rights>2021 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3938-a33e142716fceeff8f1be75786f32ec993c7bc4512433e3e82a5e8dcfd3ef8a33</citedby><cites>FETCH-LOGICAL-c3938-a33e142716fceeff8f1be75786f32ec993c7bc4512433e3e82a5e8dcfd3ef8a33</cites><orcidid>0000-0002-2069-6450 ; 0000-0002-5540-9685 ; 0000-0003-0985-6959 ; 0000-0001-8632-4505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsap.13318$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsap.13318$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33724496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryan, D.</creatorcontrib><creatorcontrib>Pérez‐Accino, J.</creatorcontrib><creatorcontrib>Gonçalves, R.</creatorcontrib><creatorcontrib>Czopowicz, M.</creatorcontrib><creatorcontrib>Bertolani, C.</creatorcontrib><creatorcontrib>Tabar, M. D.</creatorcontrib><creatorcontrib>Puig, J.</creatorcontrib><creatorcontrib>Ros, C.</creatorcontrib><creatorcontrib>Suñol, A.</creatorcontrib><title>Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020)</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Objectives
To review the clinical findings and outcome in dogs diagnosed with insulinoma, and to assess which factors are predictors of overall survival. Additionally, to describe the neurological manifestations of this population and their correlation with survival.
Materials and Methods
Retrospective multicentric study of canine insulinoma cases (2009 to 2020). Signalment, clinical history, neurological examination, diagnostic findings, treatment and outcome were obtained from clinical records. Univariate and multivariate analyses were used to compare the overall survival.
Results
One hundred and sixteen cases were included. Median duration of clinical signs before presentation was 1.5 months. The most common presenting clinical signs were weakness (59.5%), epileptic seizures (33.6%) and changes in consciousness or behaviour (27.6%). Three dogs were suspected to have paroxysmal dyskinesia. Thirty‐two dogs had an abnormal neurological examination, most commonly showing obtundation (28.1%), decreased withdrawal reflexes (21.9%) and absent menace response (18.8%). Overall survival for dogs undergoing surgery (20 months) was significantly longer than in medically treated (8 months; adjusted hazard ratio: 0.33; 95% confidence interval: 0.18, 0.59). Presence of metastases was the only other variable associated with prognosis (adjusted hazard ratio 1.72; 95% confidence interval: 1.02, 2.91).
Clinical Significance
Clinical signs of canine insulinoma are vague and non‐specific. Weakness, epileptic seizures and changes in mentation or behaviour were the most commonly reported. Obtunded mentation and forebrain neurolocalisation were the main neurological manifestations. Dogs undergoing surgery had a longer overall survival compared to medically treated cases, and dogs with metastasis had a shorter overall survival regardless of treatment modality. Abnormalities in the neurological examination did not correlate with prognosis.</description><subject>Animals</subject><subject>Confidence intervals</subject><subject>Convulsions & seizures</subject><subject>Dog Diseases - diagnosis</subject><subject>Dogs</subject><subject>Dyskinesia</subject><subject>Epilepsy</subject><subject>Forebrain</subject><subject>Insulinoma</subject><subject>Insulinoma - veterinary</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Neuroendocrine tumors</subject><subject>Pancreatic Neoplasms - veterinary</subject><subject>Prognosis</subject><subject>Reflexes</subject><subject>Retrospective Studies</subject><subject>Seizures</subject><subject>Seizures - veterinary</subject><subject>Surgery</subject><subject>Survival</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtOwzAQhi0EglLYcABkiQ0gAn4kscMOVTyFBBKwjlxnXFwldombInYcgSNwFo7CSTAUWLDAm5E9nz-N_SO0Qck-jetgHNRkn3JO5QLqUZHKJJNMLKIeIYwlaUbJCloNYRy3eSrIMlrhXLA0LfIeaga1dVarGhvrKutGYQ876Fpf-9HXcaOcNRCmamq9C1i5CoeundlZ7HmDKz8K-NFO799erQtdlPlGHWJKc6xVgIC3GSHF-_MLI4zsrKElo-oA69-1j-5Ojm8HZ8nl1en54Ogy0bzgMlGcA02ZoLnRAMZIQ4cgMiFzwxnoouBaDHV8GEsjyUEylYGstKk4GBlv99H23Dtp_UMXpy8bGzTUtXLgu1CyjFCZkSJPI7r1Bx37rnVxukhlNBOM5SJSu3NKtz6EFkw5aW2j2qeSkvIzhPIzhPIrhAhvfiu7YQPVL_rz6xGgc-DR1vD0j6q8uDm6nks_AAbfkkc</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Ryan, D.</creator><creator>Pérez‐Accino, J.</creator><creator>Gonçalves, R.</creator><creator>Czopowicz, M.</creator><creator>Bertolani, C.</creator><creator>Tabar, M. D.</creator><creator>Puig, J.</creator><creator>Ros, C.</creator><creator>Suñol, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2069-6450</orcidid><orcidid>https://orcid.org/0000-0002-5540-9685</orcidid><orcidid>https://orcid.org/0000-0003-0985-6959</orcidid><orcidid>https://orcid.org/0000-0001-8632-4505</orcidid></search><sort><creationdate>202107</creationdate><title>Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020)</title><author>Ryan, D. ; Pérez‐Accino, J. ; Gonçalves, R. ; Czopowicz, M. ; Bertolani, C. ; Tabar, M. D. ; Puig, J. ; Ros, C. ; Suñol, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-a33e142716fceeff8f1be75786f32ec993c7bc4512433e3e82a5e8dcfd3ef8a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Confidence intervals</topic><topic>Convulsions & seizures</topic><topic>Dog Diseases - diagnosis</topic><topic>Dogs</topic><topic>Dyskinesia</topic><topic>Epilepsy</topic><topic>Forebrain</topic><topic>Insulinoma</topic><topic>Insulinoma - veterinary</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Neuroendocrine tumors</topic><topic>Pancreatic Neoplasms - veterinary</topic><topic>Prognosis</topic><topic>Reflexes</topic><topic>Retrospective Studies</topic><topic>Seizures</topic><topic>Seizures - veterinary</topic><topic>Surgery</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryan, D.</creatorcontrib><creatorcontrib>Pérez‐Accino, J.</creatorcontrib><creatorcontrib>Gonçalves, R.</creatorcontrib><creatorcontrib>Czopowicz, M.</creatorcontrib><creatorcontrib>Bertolani, C.</creatorcontrib><creatorcontrib>Tabar, M. D.</creatorcontrib><creatorcontrib>Puig, J.</creatorcontrib><creatorcontrib>Ros, C.</creatorcontrib><creatorcontrib>Suñol, A.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryan, D.</au><au>Pérez‐Accino, J.</au><au>Gonçalves, R.</au><au>Czopowicz, M.</au><au>Bertolani, C.</au><au>Tabar, M. D.</au><au>Puig, J.</au><au>Ros, C.</au><au>Suñol, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020)</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>2021-07</date><risdate>2021</risdate><volume>62</volume><issue>7</issue><spage>531</spage><epage>539</epage><pages>531-539</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Objectives
To review the clinical findings and outcome in dogs diagnosed with insulinoma, and to assess which factors are predictors of overall survival. Additionally, to describe the neurological manifestations of this population and their correlation with survival.
Materials and Methods
Retrospective multicentric study of canine insulinoma cases (2009 to 2020). Signalment, clinical history, neurological examination, diagnostic findings, treatment and outcome were obtained from clinical records. Univariate and multivariate analyses were used to compare the overall survival.
Results
One hundred and sixteen cases were included. Median duration of clinical signs before presentation was 1.5 months. The most common presenting clinical signs were weakness (59.5%), epileptic seizures (33.6%) and changes in consciousness or behaviour (27.6%). Three dogs were suspected to have paroxysmal dyskinesia. Thirty‐two dogs had an abnormal neurological examination, most commonly showing obtundation (28.1%), decreased withdrawal reflexes (21.9%) and absent menace response (18.8%). Overall survival for dogs undergoing surgery (20 months) was significantly longer than in medically treated (8 months; adjusted hazard ratio: 0.33; 95% confidence interval: 0.18, 0.59). Presence of metastases was the only other variable associated with prognosis (adjusted hazard ratio 1.72; 95% confidence interval: 1.02, 2.91).
Clinical Significance
Clinical signs of canine insulinoma are vague and non‐specific. Weakness, epileptic seizures and changes in mentation or behaviour were the most commonly reported. Obtunded mentation and forebrain neurolocalisation were the main neurological manifestations. Dogs undergoing surgery had a longer overall survival compared to medically treated cases, and dogs with metastasis had a shorter overall survival regardless of treatment modality. Abnormalities in the neurological examination did not correlate with prognosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>33724496</pmid><doi>10.1111/jsap.13318</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2069-6450</orcidid><orcidid>https://orcid.org/0000-0002-5540-9685</orcidid><orcidid>https://orcid.org/0000-0003-0985-6959</orcidid><orcidid>https://orcid.org/0000-0001-8632-4505</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Confidence intervals Convulsions & seizures Dog Diseases - diagnosis Dogs Dyskinesia Epilepsy Forebrain Insulinoma Insulinoma - veterinary Medical prognosis Metastases Neuroendocrine tumors Pancreatic Neoplasms - veterinary Prognosis Reflexes Retrospective Studies Seizures Seizures - veterinary Surgery Survival |
| title | Clinical findings, neurological manifestations and survival of dogs with insulinoma: 116 cases (2009‐2020) |
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