Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan
Aim The present study investigated the current situation regarding intrauterine blood transfusion (IUT) for fetal anemia in Japan. Methods We conducted a nationwide, multicenter, retrospective cohort questionnaire survey for cases that underwent IUT from 2011 to 2015. The questionnaire required peri...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-06, Vol.47 (6), p.2076-2081 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Mizuuchi, Masahito Murotsuki, Jun Ishii, Keisuke Yamamoto, Ryo Sasahara, Jun Wada, Seiji Takahashi, Yuichiro Nakata, Masahiko Murakoshi, Takeshi Sago, Haruhiko |
| description | Aim
The present study investigated the current situation regarding intrauterine blood transfusion (IUT) for fetal anemia in Japan.
Methods
We conducted a nationwide, multicenter, retrospective cohort questionnaire survey for cases that underwent IUT from 2011 to 2015. The questionnaire required perioperative information, indications, details of the procedure, procedure‐related complications, and neonatal morbidity.
Results
A total of 100 IUT procedures were performed in 66 cases at 19 institutions during the study period. The most frequent indication of IUT was complicated monochorionic diamniotic (MCDA) twins in 28 (42.4%) cases, followed by 16 (24.2%) cases of red‐cell alloimmunization, and 10 (15.2%) cases of parvovirus B19 infection. IUT was performed through the umbilical cord in the vast of majority cases (92%). Bleeding from the IUT site was the most common adverse event (40%). Two cases (2%) underwent emergency cesarean section after the procedure. There were no cases of rupture of membrane or intrauterine infection after IUT. The neonatal survival rate was 77.3% in the 66 total cases and 64% in the hydrops cases. The neonatal survival rates in MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection were 75%, 93.8%, and 70%, respectively.
Conclusions
IUT was performed for mainly three indications in Japan: MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection. The incidences of severe adverse events seemed very low. The outcomes after IUT were favorable with variations in survival rates according to indications. However, further studies with long‐term follow‐up will be required to assess the effectiveness of IUT, especially for complicated MCDA twins. |
| doi_str_mv | 10.1111/jog.14746 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2501850427</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2539691727</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3776-b84d4011f3af98a79eac55809e217a9d8a93e6cd306d751c9fff5dd7133de0ea3</originalsourceid><addsrcrecordid>eNp10EFLwzAYBuAgipvTg39AAl700C1p2qY5ytCpTHfRc8maLyOjbWbSOvbvjev0IJhLwseTl48XoUtKxjScydquxjThSXaEhjRJeER4mh2HN0tolBOeDdCZ92tCKBc0P0UDxnjMBBFD9PIqW2ObrVGAfec-YYetxqZpnexacKYBvKysVTgMGq87HzDW1mENraywbKA2Mnj8LDeyOUcnWlYeLg73CL0_3L9NH6P5YvY0vZtHJeM8i5Z5ohJCqWZSi1xyAbJM05wIiCmXQuVSMMhKxUimeEpLobVOleKUMQUEJBuhmz534-xHB74tauNLqKqwj-18EaeE5ilJYh7o9R-6tp1rwnZBMZEJyvfqtlels9470MXGmVq6XUFJ8d1x-LUq9h0He3VI7JY1qF_5U2oAkx5sTQW7_5OK58Wsj_wC3hSFjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2539691727</pqid></control><display><type>article</type><title>Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mizuuchi, Masahito ; Murotsuki, Jun ; Ishii, Keisuke ; Yamamoto, Ryo ; Sasahara, Jun ; Wada, Seiji ; Takahashi, Yuichiro ; Nakata, Masahiko ; Murakoshi, Takeshi ; Sago, Haruhiko</creator><creatorcontrib>Mizuuchi, Masahito ; Murotsuki, Jun ; Ishii, Keisuke ; Yamamoto, Ryo ; Sasahara, Jun ; Wada, Seiji ; Takahashi, Yuichiro ; Nakata, Masahiko ; Murakoshi, Takeshi ; Sago, Haruhiko</creatorcontrib><description>Aim
The present study investigated the current situation regarding intrauterine blood transfusion (IUT) for fetal anemia in Japan.
Methods
We conducted a nationwide, multicenter, retrospective cohort questionnaire survey for cases that underwent IUT from 2011 to 2015. The questionnaire required perioperative information, indications, details of the procedure, procedure‐related complications, and neonatal morbidity.
Results
A total of 100 IUT procedures were performed in 66 cases at 19 institutions during the study period. The most frequent indication of IUT was complicated monochorionic diamniotic (MCDA) twins in 28 (42.4%) cases, followed by 16 (24.2%) cases of red‐cell alloimmunization, and 10 (15.2%) cases of parvovirus B19 infection. IUT was performed through the umbilical cord in the vast of majority cases (92%). Bleeding from the IUT site was the most common adverse event (40%). Two cases (2%) underwent emergency cesarean section after the procedure. There were no cases of rupture of membrane or intrauterine infection after IUT. The neonatal survival rate was 77.3% in the 66 total cases and 64% in the hydrops cases. The neonatal survival rates in MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection were 75%, 93.8%, and 70%, respectively.
Conclusions
IUT was performed for mainly three indications in Japan: MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection. The incidences of severe adverse events seemed very low. The outcomes after IUT were favorable with variations in survival rates according to indications. However, further studies with long‐term follow‐up will be required to assess the effectiveness of IUT, especially for complicated MCDA twins.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14746</identifier><identifier>PMID: 33723909</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Adverse events ; Anemia ; Blood transfusion ; Blood transfusions ; Cesarean section ; Edema ; fetal anemia ; Fetuses ; Infections ; intrauterine blood transfusion ; Isoimmunization ; monochorionic diamniotic twin pregnancy ; Morbidity ; Neonates ; parvovirus B19 infection ; Parvoviruses ; Performance evaluation ; Questionnaires ; red‐cell alloimmunization ; Twins ; Umbilical cord</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-06, Vol.47 (6), p.2076-2081</ispartof><rights>2021 Japan Society of Obstetrics and Gynecology</rights><rights>2021 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3776-b84d4011f3af98a79eac55809e217a9d8a93e6cd306d751c9fff5dd7133de0ea3</citedby><cites>FETCH-LOGICAL-c3776-b84d4011f3af98a79eac55809e217a9d8a93e6cd306d751c9fff5dd7133de0ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14746$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14746$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33723909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizuuchi, Masahito</creatorcontrib><creatorcontrib>Murotsuki, Jun</creatorcontrib><creatorcontrib>Ishii, Keisuke</creatorcontrib><creatorcontrib>Yamamoto, Ryo</creatorcontrib><creatorcontrib>Sasahara, Jun</creatorcontrib><creatorcontrib>Wada, Seiji</creatorcontrib><creatorcontrib>Takahashi, Yuichiro</creatorcontrib><creatorcontrib>Nakata, Masahiko</creatorcontrib><creatorcontrib>Murakoshi, Takeshi</creatorcontrib><creatorcontrib>Sago, Haruhiko</creatorcontrib><title>Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
The present study investigated the current situation regarding intrauterine blood transfusion (IUT) for fetal anemia in Japan.
Methods
We conducted a nationwide, multicenter, retrospective cohort questionnaire survey for cases that underwent IUT from 2011 to 2015. The questionnaire required perioperative information, indications, details of the procedure, procedure‐related complications, and neonatal morbidity.
Results
A total of 100 IUT procedures were performed in 66 cases at 19 institutions during the study period. The most frequent indication of IUT was complicated monochorionic diamniotic (MCDA) twins in 28 (42.4%) cases, followed by 16 (24.2%) cases of red‐cell alloimmunization, and 10 (15.2%) cases of parvovirus B19 infection. IUT was performed through the umbilical cord in the vast of majority cases (92%). Bleeding from the IUT site was the most common adverse event (40%). Two cases (2%) underwent emergency cesarean section after the procedure. There were no cases of rupture of membrane or intrauterine infection after IUT. The neonatal survival rate was 77.3% in the 66 total cases and 64% in the hydrops cases. The neonatal survival rates in MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection were 75%, 93.8%, and 70%, respectively.
Conclusions
IUT was performed for mainly three indications in Japan: MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection. The incidences of severe adverse events seemed very low. The outcomes after IUT were favorable with variations in survival rates according to indications. However, further studies with long‐term follow‐up will be required to assess the effectiveness of IUT, especially for complicated MCDA twins.</description><subject>Adverse events</subject><subject>Anemia</subject><subject>Blood transfusion</subject><subject>Blood transfusions</subject><subject>Cesarean section</subject><subject>Edema</subject><subject>fetal anemia</subject><subject>Fetuses</subject><subject>Infections</subject><subject>intrauterine blood transfusion</subject><subject>Isoimmunization</subject><subject>monochorionic diamniotic twin pregnancy</subject><subject>Morbidity</subject><subject>Neonates</subject><subject>parvovirus B19 infection</subject><subject>Parvoviruses</subject><subject>Performance evaluation</subject><subject>Questionnaires</subject><subject>red‐cell alloimmunization</subject><subject>Twins</subject><subject>Umbilical cord</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10EFLwzAYBuAgipvTg39AAl700C1p2qY5ytCpTHfRc8maLyOjbWbSOvbvjev0IJhLwseTl48XoUtKxjScydquxjThSXaEhjRJeER4mh2HN0tolBOeDdCZ92tCKBc0P0UDxnjMBBFD9PIqW2ObrVGAfec-YYetxqZpnexacKYBvKysVTgMGq87HzDW1mENraywbKA2Mnj8LDeyOUcnWlYeLg73CL0_3L9NH6P5YvY0vZtHJeM8i5Z5ohJCqWZSi1xyAbJM05wIiCmXQuVSMMhKxUimeEpLobVOleKUMQUEJBuhmz534-xHB74tauNLqKqwj-18EaeE5ilJYh7o9R-6tp1rwnZBMZEJyvfqtlels9470MXGmVq6XUFJ8d1x-LUq9h0He3VI7JY1qF_5U2oAkx5sTQW7_5OK58Wsj_wC3hSFjw</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Mizuuchi, Masahito</creator><creator>Murotsuki, Jun</creator><creator>Ishii, Keisuke</creator><creator>Yamamoto, Ryo</creator><creator>Sasahara, Jun</creator><creator>Wada, Seiji</creator><creator>Takahashi, Yuichiro</creator><creator>Nakata, Masahiko</creator><creator>Murakoshi, Takeshi</creator><creator>Sago, Haruhiko</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan</title><author>Mizuuchi, Masahito ; Murotsuki, Jun ; Ishii, Keisuke ; Yamamoto, Ryo ; Sasahara, Jun ; Wada, Seiji ; Takahashi, Yuichiro ; Nakata, Masahiko ; Murakoshi, Takeshi ; Sago, Haruhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3776-b84d4011f3af98a79eac55809e217a9d8a93e6cd306d751c9fff5dd7133de0ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adverse events</topic><topic>Anemia</topic><topic>Blood transfusion</topic><topic>Blood transfusions</topic><topic>Cesarean section</topic><topic>Edema</topic><topic>fetal anemia</topic><topic>Fetuses</topic><topic>Infections</topic><topic>intrauterine blood transfusion</topic><topic>Isoimmunization</topic><topic>monochorionic diamniotic twin pregnancy</topic><topic>Morbidity</topic><topic>Neonates</topic><topic>parvovirus B19 infection</topic><topic>Parvoviruses</topic><topic>Performance evaluation</topic><topic>Questionnaires</topic><topic>red‐cell alloimmunization</topic><topic>Twins</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuuchi, Masahito</creatorcontrib><creatorcontrib>Murotsuki, Jun</creatorcontrib><creatorcontrib>Ishii, Keisuke</creatorcontrib><creatorcontrib>Yamamoto, Ryo</creatorcontrib><creatorcontrib>Sasahara, Jun</creatorcontrib><creatorcontrib>Wada, Seiji</creatorcontrib><creatorcontrib>Takahashi, Yuichiro</creatorcontrib><creatorcontrib>Nakata, Masahiko</creatorcontrib><creatorcontrib>Murakoshi, Takeshi</creatorcontrib><creatorcontrib>Sago, Haruhiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuuchi, Masahito</au><au>Murotsuki, Jun</au><au>Ishii, Keisuke</au><au>Yamamoto, Ryo</au><au>Sasahara, Jun</au><au>Wada, Seiji</au><au>Takahashi, Yuichiro</au><au>Nakata, Masahiko</au><au>Murakoshi, Takeshi</au><au>Sago, Haruhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2021-06</date><risdate>2021</risdate><volume>47</volume><issue>6</issue><spage>2076</spage><epage>2081</epage><pages>2076-2081</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
The present study investigated the current situation regarding intrauterine blood transfusion (IUT) for fetal anemia in Japan.
Methods
We conducted a nationwide, multicenter, retrospective cohort questionnaire survey for cases that underwent IUT from 2011 to 2015. The questionnaire required perioperative information, indications, details of the procedure, procedure‐related complications, and neonatal morbidity.
Results
A total of 100 IUT procedures were performed in 66 cases at 19 institutions during the study period. The most frequent indication of IUT was complicated monochorionic diamniotic (MCDA) twins in 28 (42.4%) cases, followed by 16 (24.2%) cases of red‐cell alloimmunization, and 10 (15.2%) cases of parvovirus B19 infection. IUT was performed through the umbilical cord in the vast of majority cases (92%). Bleeding from the IUT site was the most common adverse event (40%). Two cases (2%) underwent emergency cesarean section after the procedure. There were no cases of rupture of membrane or intrauterine infection after IUT. The neonatal survival rate was 77.3% in the 66 total cases and 64% in the hydrops cases. The neonatal survival rates in MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection were 75%, 93.8%, and 70%, respectively.
Conclusions
IUT was performed for mainly three indications in Japan: MCDA twins, red‐cell alloimmunization, and parvovirus B19 infection. The incidences of severe adverse events seemed very low. The outcomes after IUT were favorable with variations in survival rates according to indications. However, further studies with long‐term follow‐up will be required to assess the effectiveness of IUT, especially for complicated MCDA twins.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33723909</pmid><doi>10.1111/jog.14746</doi><tpages>6</tpages></addata></record> |
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| subjects | Adverse events Anemia Blood transfusion Blood transfusions Cesarean section Edema fetal anemia Fetuses Infections intrauterine blood transfusion Isoimmunization monochorionic diamniotic twin pregnancy Morbidity Neonates parvovirus B19 infection Parvoviruses Performance evaluation Questionnaires red‐cell alloimmunization Twins Umbilical cord |
| title | Nationwide survey of intrauterine blood transfusion for fetal anemia in Japan |
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