DPV UL41 gene encoding protein induces host shutoff activity and affects viral replication

•DPV pUL41 degrades RNA polymerase (Pol) II-transcribed translatable RNA and induces protein synthesis shutoff.•DPV CHv-BAC-ΔUL41 mutant virus exhibits a significant viral growth defect and plaque size reduction in DEF cells.•DPV pUL41 significantly affects the viral DNA replication and viral releas...

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Veröffentlicht in:	Veterinary microbiology 2021-04, Vol.255, p.108979-108979, Article 108979
Hauptverfasser:	He, Tianqiong, Wang, Mingshu, Cheng, Anchun, Yang, Qiao, Jia, Renyong, Wu, Ying, Huang, Juan, Tian, Bin, Liu, Mafeng, Chen, Shun, Zhao, Xin-Xin, Zhu, Dekang, Zhang, Shaqiu, Ou, Xuming, Mao, Sai, Gao, Qun, Sun, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA biosynthesis DNA-directed RNA polymerase DPV Duck plague Herpes simplex mRNA Plague Protein biosynthesis Proteins Replication RNA polymerase Transcription UL41 UL41 gene VHS Viral replication Virions Viruses
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