MicroRNA directly modulates cardiac ion channel

A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of K ir 2.1 to maintain cardiac homeostasis, and disruption to this relationship predisposes the heart to a greater risk of arrhythmogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews cardiology 2021-05, Vol.18 (5), p.308-308
1. Verfasser:	Fitzpatrick, Ciarán Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4019/592/75/29 692/420/2489/144 Action potentials (Electrophysiology) Arrhythmia Binding sites (Biochemistry) Biological control systems Cardiac Imaging Cardiac Surgery Cardiology Cardiovascular research Development and progression Health aspects Heart Humans Ion channels Ion Channels - genetics Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - genetics Physiological aspects Research Highlight
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