Cytosolic Delivery of Thiolated Mn‐cGAMP Nanovaccine to Enhance the Antitumor Immune Responses

As a stimulator of interferon gene (STING), cyclic dinucleotide activates a broad cellular immune response for anti‐cancer immunotherapy (CIT). However, the inherent of instability of 2′ 3′‐cyclic‐GMP‐AMP (cGAMP) with poor cellular targeting, rapid clearance, and inefficient transport to the cytopla...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-04, Vol.17 (17), p.e2006970-n/a
Hauptverfasser:	Chen, Chengyun, Tong, Yuhong, Zheng, Youshi, Shi, Yingjun, Chen, Zhaowei, Li, Juan, Liu, Xiaolong, Zhang, Da, Yang, Huanghao
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer immunotherapy cGAMP Cytokines Cytoplasm cytosolic delivery Immune system Interferon Lymphocytes manganese Manganese ions Monoclonal antibodies Nanotechnology Stimulators STING pathway
Online-Zugang:	Volltext
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