Contamination of lenalidomide on blister packages after administration and its exposure countermeasures
Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine fa...
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| Veröffentlicht in: | Current problems in cancer 2021-10, Vol.45 (5), p.100727-100727, Article 100727 |
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| creator | Komuro, Masato Furuya, Takahito Ohashi, Yasukata Watabe, Daisuke Nomura, Hisanaga Komuro, Ayumi Tabei, Akira Sawamura, Seigo Hyakutake, Hiroshi Kusu, Hiroko Kita, Yuri Terakado, Hiroyuki |
| description | Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine facilities involved with the RevMate program (the Japanese REMS program) participated in this study. Blister packages (10 capsules/ sheet, no cuts) were collected from each institution after the administration of 5-mg Revlimid capsules. Additionally, the safety performance of different gloves was tested. Results: A total of 18 samples were analyzed and the results revealed that all samples were contaminated with lenalidomide. Our questionnaire revealed that all pharmacists handled the blister packages with their bare hands when they were checking the remaining capsules of lenalidomide. We analyzed gloves made from four different materials (nitrile, polyvinyl chloride, latex, and polyethylene) and found no permeability in any glove type. Conclusion: We conclude that the spent blister package is a potential source of exposure to lenalidomide. All medical staff and caregivers should wear gloves when they handle lenalidomide. |
| doi_str_mv | 10.1016/j.currproblcancer.2021.100727 |
| format | Article |
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However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine facilities involved with the RevMate program (the Japanese REMS program) participated in this study. Blister packages (10 capsules/ sheet, no cuts) were collected from each institution after the administration of 5-mg Revlimid capsules. Additionally, the safety performance of different gloves was tested. Results: A total of 18 samples were analyzed and the results revealed that all samples were contaminated with lenalidomide. Our questionnaire revealed that all pharmacists handled the blister packages with their bare hands when they were checking the remaining capsules of lenalidomide. We analyzed gloves made from four different materials (nitrile, polyvinyl chloride, latex, and polyethylene) and found no permeability in any glove type. Conclusion: We conclude that the spent blister package is a potential source of exposure to lenalidomide. All medical staff and caregivers should wear gloves when they handle lenalidomide.</description><identifier>ISSN: 0147-0272</identifier><identifier>EISSN: 1535-6345</identifier><identifier>DOI: 10.1016/j.currproblcancer.2021.100727</identifier><identifier>PMID: 33714590</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blister package sheet ; Contamination ; Exposure ; Gloves, Protective ; Humans ; Japan ; Lenalidomide ; Lenalidomide - adverse effects ; Lenalidomide - analysis ; Occupational Exposure - analysis ; Occupational Exposure - prevention & control ; Pharmacists ; Product Packaging ; Surveys and Questionnaires</subject><ispartof>Current problems in cancer, 2021-10, Vol.45 (5), p.100727-100727, Article 100727</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-9dfd9e4512db056a42aaeb2022be4877e0937a28d3547cfa27f7774cf109ba483</citedby><cites>FETCH-LOGICAL-c444t-9dfd9e4512db056a42aaeb2022be4877e0937a28d3547cfa27f7774cf109ba483</cites><orcidid>0000-0002-3445-9595</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.currproblcancer.2021.100727$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33714590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komuro, Masato</creatorcontrib><creatorcontrib>Furuya, Takahito</creatorcontrib><creatorcontrib>Ohashi, Yasukata</creatorcontrib><creatorcontrib>Watabe, Daisuke</creatorcontrib><creatorcontrib>Nomura, Hisanaga</creatorcontrib><creatorcontrib>Komuro, Ayumi</creatorcontrib><creatorcontrib>Tabei, Akira</creatorcontrib><creatorcontrib>Sawamura, Seigo</creatorcontrib><creatorcontrib>Hyakutake, Hiroshi</creatorcontrib><creatorcontrib>Kusu, Hiroko</creatorcontrib><creatorcontrib>Kita, Yuri</creatorcontrib><creatorcontrib>Terakado, Hiroyuki</creatorcontrib><title>Contamination of lenalidomide on blister packages after administration and its exposure countermeasures</title><title>Current problems in cancer</title><addtitle>Curr Probl Cancer</addtitle><description>Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine facilities involved with the RevMate program (the Japanese REMS program) participated in this study. Blister packages (10 capsules/ sheet, no cuts) were collected from each institution after the administration of 5-mg Revlimid capsules. Additionally, the safety performance of different gloves was tested. Results: A total of 18 samples were analyzed and the results revealed that all samples were contaminated with lenalidomide. Our questionnaire revealed that all pharmacists handled the blister packages with their bare hands when they were checking the remaining capsules of lenalidomide. We analyzed gloves made from four different materials (nitrile, polyvinyl chloride, latex, and polyethylene) and found no permeability in any glove type. Conclusion: We conclude that the spent blister package is a potential source of exposure to lenalidomide. All medical staff and caregivers should wear gloves when they handle lenalidomide.</description><subject>Blister package sheet</subject><subject>Contamination</subject><subject>Exposure</subject><subject>Gloves, Protective</subject><subject>Humans</subject><subject>Japan</subject><subject>Lenalidomide</subject><subject>Lenalidomide - adverse effects</subject><subject>Lenalidomide - analysis</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational Exposure - prevention & control</subject><subject>Pharmacists</subject><subject>Product Packaging</subject><subject>Surveys and Questionnaires</subject><issn>0147-0272</issn><issn>1535-6345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAQhi0EglL4CygLEkuK7dh1MzCgii8JiQVm62JfKpckLnaC4N_jKMDAxGSd73nvdA8h54wuGGXLy-3CDCHsgq8aA53BsOCUs9Sjiqs9MmOykPmyEHKfzCgTKqdc8SNyHOOWUsZLJg_JUVEoJmRJZ2Sz9l0Preugd77LfJ012EHjrG-dxSx9VY2LPYZsB-YVNhgzqMcSbAqlTpiC0NnM9THDj52PQ8DM-KFLXIswlvGEHNTQRDz9fufk5fbmeX2fPz7dPayvH3MjhOjz0ta2RCEZtxWVSxAcAKt0Ia9QrJRCWhYK-MoWUihTA1e1UkqYmtGyArEq5uRimpsMvQ0Ye926aLBpoEM_RM3lKEUWXCX0akJN8DEGrPUuuBbCp2ZUj671Vv9xrUfXenKd8mffq4aqRfub_pGbgLsJwHTwu0vxaBymOdYFNL223v1z1RcF2pw5</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Komuro, Masato</creator><creator>Furuya, Takahito</creator><creator>Ohashi, Yasukata</creator><creator>Watabe, Daisuke</creator><creator>Nomura, Hisanaga</creator><creator>Komuro, Ayumi</creator><creator>Tabei, Akira</creator><creator>Sawamura, Seigo</creator><creator>Hyakutake, Hiroshi</creator><creator>Kusu, Hiroko</creator><creator>Kita, Yuri</creator><creator>Terakado, Hiroyuki</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3445-9595</orcidid></search><sort><creationdate>202110</creationdate><title>Contamination of lenalidomide on blister packages after administration and its exposure countermeasures</title><author>Komuro, Masato ; Furuya, Takahito ; Ohashi, Yasukata ; Watabe, Daisuke ; Nomura, Hisanaga ; Komuro, Ayumi ; Tabei, Akira ; Sawamura, Seigo ; Hyakutake, Hiroshi ; Kusu, Hiroko ; Kita, Yuri ; Terakado, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-9dfd9e4512db056a42aaeb2022be4877e0937a28d3547cfa27f7774cf109ba483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blister package sheet</topic><topic>Contamination</topic><topic>Exposure</topic><topic>Gloves, Protective</topic><topic>Humans</topic><topic>Japan</topic><topic>Lenalidomide</topic><topic>Lenalidomide - adverse effects</topic><topic>Lenalidomide - analysis</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational Exposure - prevention & control</topic><topic>Pharmacists</topic><topic>Product Packaging</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komuro, Masato</creatorcontrib><creatorcontrib>Furuya, Takahito</creatorcontrib><creatorcontrib>Ohashi, Yasukata</creatorcontrib><creatorcontrib>Watabe, Daisuke</creatorcontrib><creatorcontrib>Nomura, Hisanaga</creatorcontrib><creatorcontrib>Komuro, Ayumi</creatorcontrib><creatorcontrib>Tabei, Akira</creatorcontrib><creatorcontrib>Sawamura, Seigo</creatorcontrib><creatorcontrib>Hyakutake, Hiroshi</creatorcontrib><creatorcontrib>Kusu, Hiroko</creatorcontrib><creatorcontrib>Kita, Yuri</creatorcontrib><creatorcontrib>Terakado, Hiroyuki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current problems in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komuro, Masato</au><au>Furuya, Takahito</au><au>Ohashi, Yasukata</au><au>Watabe, Daisuke</au><au>Nomura, Hisanaga</au><au>Komuro, Ayumi</au><au>Tabei, Akira</au><au>Sawamura, Seigo</au><au>Hyakutake, Hiroshi</au><au>Kusu, Hiroko</au><au>Kita, Yuri</au><au>Terakado, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contamination of lenalidomide on blister packages after administration and its exposure countermeasures</atitle><jtitle>Current problems in cancer</jtitle><addtitle>Curr Probl Cancer</addtitle><date>2021-10</date><risdate>2021</risdate><volume>45</volume><issue>5</issue><spage>100727</spage><epage>100727</epage><pages>100727-100727</pages><artnum>100727</artnum><issn>0147-0272</issn><eissn>1535-6345</eissn><abstract>Background: Reliable exposure control measures are needed to avoid occupational exposures from hazardous drugs. However, there is little information on blister packages concerning exposure. We investigated the contamination and exposure control methods of lenalidomide. Materials and Methods: Nine facilities involved with the RevMate program (the Japanese REMS program) participated in this study. Blister packages (10 capsules/ sheet, no cuts) were collected from each institution after the administration of 5-mg Revlimid capsules. Additionally, the safety performance of different gloves was tested. Results: A total of 18 samples were analyzed and the results revealed that all samples were contaminated with lenalidomide. Our questionnaire revealed that all pharmacists handled the blister packages with their bare hands when they were checking the remaining capsules of lenalidomide. We analyzed gloves made from four different materials (nitrile, polyvinyl chloride, latex, and polyethylene) and found no permeability in any glove type. Conclusion: We conclude that the spent blister package is a potential source of exposure to lenalidomide. All medical staff and caregivers should wear gloves when they handle lenalidomide.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33714590</pmid><doi>10.1016/j.currproblcancer.2021.100727</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3445-9595</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blister package sheet Contamination Exposure Gloves, Protective Humans Japan Lenalidomide Lenalidomide - adverse effects Lenalidomide - analysis Occupational Exposure - analysis Occupational Exposure - prevention & control Pharmacists Product Packaging Surveys and Questionnaires |
| title | Contamination of lenalidomide on blister packages after administration and its exposure countermeasures |
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