The soluble guanylate cyclase stimulator, 1-nitro-2-phenylethane, reverses monocrotaline-induced pulmonary arterial hypertension in rats

We examined the effects of treatment with 1-nitro-2-phenylethane (NP), a novel soluble guanylate cyclase stimulator, on monocrotaline (MCT)-induced PAH in rats. At day 0, male adult rats were injected with a single subcutaneous (s.c.) dose of monocrotaline (60 mg/kg). Control (CNT) rats received an...

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Veröffentlicht in:	Life sciences (1973) 2021-06, Vol.275, p.119334-119334, Article 119334
Hauptverfasser:	Gonzaga-Costa, Karoline, Roque, Cássia Rodrigues, Vasconcelos-Silva, Alfredo Augusto, Sousa-Brito, Hellida Larissa, Martins, Conceição Silva, Caetano-Souza, Marta Maria, Duarte, Glória Pinto, da Silva, Joyce Kelly Rosário, Borges, Rosivaldo Santos, dos Santos, Armênio Aguiar, Magalhães, Pedro Jorge Caldas, Lahlou, Saad
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Nitro-2-phenylethane Acceleration Acetylcholine Animals Aorta Arterioles Benzene Derivatives - pharmacology Blood pressure Diameters Echocardiography Endothelial dysfunction Endothelium, Vascular - drug effects Enlargement Flow velocity Guanylate cyclase Hemodynamics Hemodynamics - drug effects Hypertension Hypertrophy Male Monocrotaline Monocrotaline - antagonists & inhibitors Monocrotaline - pharmacology Nitric oxide Pulmonary arterial hypertension Pulmonary Arterial Hypertension - chemically induced Pulmonary Arterial Hypertension - diagnostic imaging Pulmonary Arterial Hypertension - drug therapy Pulmonary arteries Pulmonary artery Pulmonary Artery - drug effects Pulmonary vascular remodeling Rats Rats, Wistar Right ventricle hypertrophy Soluble Guanylyl Cyclase - drug effects Stiffness Stimulators Vascular Remodeling - drug effects Veins & arteries Ventricle Wall thickness
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