Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations
Summary Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present...
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| Veröffentlicht in: | Clinical and experimental dermatology 2021-08, Vol.46 (6), p.1097-1101 |
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| container_title | Clinical and experimental dermatology |
| container_volume | 46 |
| creator | Moya‐Martínez, C. Núñez‐Hipólito, L. Barrio‐González, S. Santonja, C. Jo‐Velasco, M. Lorda‐Sánchez, I. Fariña‐Sabaris, M. C. Requena, L. |
| description | Summary
Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of AHS, as continuance or reintroduction of the drug can led to multiorgan failure and cardiovascular collapse. |
| doi_str_mv | 10.1111/ced.14643 |
| format | Article |
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Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of AHS, as continuance or reintroduction of the drug can led to multiorgan failure and cardiovascular collapse.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.14643</identifier><identifier>PMID: 33713349</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Azathioprine ; Fever ; Hypersensitivity ; Immunosuppressive agents ; Methyltransferase ; Reintroduction ; Thiopurine S-methyltransferase</subject><ispartof>Clinical and experimental dermatology, 2021-08, Vol.46 (6), p.1097-1101</ispartof><rights>2021 British Association of Dermatologists</rights><rights>2021 British Association of Dermatologists.</rights><rights>Copyright © 2021 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-ad9514f9b9ea34186f7c58946897664829ab0e59586953ea7d33e46be7e3cc583</citedby><cites>FETCH-LOGICAL-c3533-ad9514f9b9ea34186f7c58946897664829ab0e59586953ea7d33e46be7e3cc583</cites><orcidid>0000-0002-0394-1282 ; 0000-0002-1045-4810</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33713349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moya‐Martínez, C.</creatorcontrib><creatorcontrib>Núñez‐Hipólito, L.</creatorcontrib><creatorcontrib>Barrio‐González, S.</creatorcontrib><creatorcontrib>Santonja, C.</creatorcontrib><creatorcontrib>Jo‐Velasco, M.</creatorcontrib><creatorcontrib>Lorda‐Sánchez, I.</creatorcontrib><creatorcontrib>Fariña‐Sabaris, M. C.</creatorcontrib><creatorcontrib>Requena, L.</creatorcontrib><title>Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of AHS, as continuance or reintroduction of the drug can led to multiorgan failure and cardiovascular collapse.</description><subject>Azathioprine</subject><subject>Fever</subject><subject>Hypersensitivity</subject><subject>Immunosuppressive agents</subject><subject>Methyltransferase</subject><subject>Reintroduction</subject><subject>Thiopurine S-methyltransferase</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10E1rGzEQBmBRGmrH7aF_oAh6aQ6bSDv6WPUWnE8I5JIeelrk9SyW8a5cSVuz-fVRus6lkLkIhodXw0vIV87OeZ6LBtfnXCgBH8icg5JFWQL7SOYMmC6UgWpGTmPcMsaBa_mJzAA0BxBmTn5fPtu0cX4fXI90M-4xROyjS-6vSyONY78OvsOfNODeh0R9S9PB08ZGjPTg0oY2Q7I9-iHSzvauxZhscr6Pn8lJa3cRvxzfBfl1c_20vCseHm_vl5cPRQMSoLBrI7lozcqgBcEr1epGVkaoymilRFUau2IojayUkYBWrwFQqBVqhCZLWJAfU-4--D9D_r7uXGxwt5uuqkvJeKmUFjLT7__RrR9Cn6_LSoJQmimV1dmkmuBjDNjWuZzOhrHmrH7tu8591__6zvbbMXFYdXn7Jt8KzuBiAge3w_H9pHp5fTVFvgDG0Ym8</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Moya‐Martínez, C.</creator><creator>Núñez‐Hipólito, L.</creator><creator>Barrio‐González, S.</creator><creator>Santonja, C.</creator><creator>Jo‐Velasco, M.</creator><creator>Lorda‐Sánchez, I.</creator><creator>Fariña‐Sabaris, M. C.</creator><creator>Requena, L.</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0394-1282</orcidid><orcidid>https://orcid.org/0000-0002-1045-4810</orcidid></search><sort><creationdate>202108</creationdate><title>Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations</title><author>Moya‐Martínez, C. ; Núñez‐Hipólito, L. ; Barrio‐González, S. ; Santonja, C. ; Jo‐Velasco, M. ; Lorda‐Sánchez, I. ; Fariña‐Sabaris, M. C. ; Requena, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-ad9514f9b9ea34186f7c58946897664829ab0e59586953ea7d33e46be7e3cc583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Azathioprine</topic><topic>Fever</topic><topic>Hypersensitivity</topic><topic>Immunosuppressive agents</topic><topic>Methyltransferase</topic><topic>Reintroduction</topic><topic>Thiopurine S-methyltransferase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moya‐Martínez, C.</creatorcontrib><creatorcontrib>Núñez‐Hipólito, L.</creatorcontrib><creatorcontrib>Barrio‐González, S.</creatorcontrib><creatorcontrib>Santonja, C.</creatorcontrib><creatorcontrib>Jo‐Velasco, M.</creatorcontrib><creatorcontrib>Lorda‐Sánchez, I.</creatorcontrib><creatorcontrib>Fariña‐Sabaris, M. C.</creatorcontrib><creatorcontrib>Requena, L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moya‐Martínez, C.</au><au>Núñez‐Hipólito, L.</au><au>Barrio‐González, S.</au><au>Santonja, C.</au><au>Jo‐Velasco, M.</au><au>Lorda‐Sánchez, I.</au><au>Fariña‐Sabaris, M. C.</au><au>Requena, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>46</volume><issue>6</issue><spage>1097</spage><epage>1101</epage><pages>1097-1101</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Azathioprine is an immunosuppressant drug used in many dermatological and nondermatological pathologies. Azathioprine hypersensitivity syndrome (AHS) is a rare idiosyncratic reaction that is not related to dose or thiopurine methyltransferase activity. Up to half of cases of AHS can present with variable cutaneous manifestations besides fever, malaise and other systemic symptoms. It is important to be aware of AHS, as continuance or reintroduction of the drug can led to multiorgan failure and cardiovascular collapse.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33713349</pmid><doi>10.1111/ced.14643</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0394-1282</orcidid><orcidid>https://orcid.org/0000-0002-1045-4810</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2021-08, Vol.46 (6), p.1097-1101 |
| issn | 0307-6938 1365-2230 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Azathioprine Fever Hypersensitivity Immunosuppressive agents Methyltransferase Reintroduction Thiopurine S-methyltransferase |
| title | Azathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestations |
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