Cytoskeletal control of the secretory immune synapse
The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the im...
Gespeichert in:
| Veröffentlicht in: | Current opinion in cell biology 2021-08, Vol.71, p.87-94 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 94 |
|---|---|
| container_issue | |
| container_start_page | 87 |
| container_title | Current opinion in cell biology |
| container_volume | 71 |
| creator | Douanne, Tiphaine Griffiths, Gillian M. |
| description | The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells. |
| doi_str_mv | 10.1016/j.ceb.2021.02.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2501266627</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0955067421000296</els_id><sourcerecordid>2501266627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-c8d4c7fd6bdab0f12193972ed7bf246fc7898bcacce8b2066290e6a971cee90c3</originalsourceid><addsrcrecordid>eNp9kE1LxDAURYMoOo7-ADfSpZvWl7STNLiSwS8YcKPr0L6-Yse2GZOM0H9vhhldunpwOffCO4xdccg4cHm7zpDqTIDgGYgMoDxiM14qnULB4ZjNQC8WKUhVnLFz79cAIEHoU3aW54pzVRYzViynYP0n9RSqPkE7Bmf7xLZJ-KDEEzoK1k1JNwzbMQbTWG08XbCTtuo9XR7unL0_Prwtn9PV69PL8n6VYq5lSLFsClRtI-umqqHlgutcK0GNqltRyBZVqcsaK0QqawFSCg0kK604EmnAfM5u9rsbZ7-25IMZOo_U99VIduuNWAAXMvZURPkeRWe9d9SajeuGyk2Gg9nJMmsTZZmdLAPCRFmxc32Y39YDNX-NXzsRuNsDFJ_87sgZjx2NSE3nCINpbPfP_A_aCHpC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501266627</pqid></control><display><type>article</type><title>Cytoskeletal control of the secretory immune synapse</title><source>Elsevier ScienceDirect Journals</source><creator>Douanne, Tiphaine ; Griffiths, Gillian M.</creator><creatorcontrib>Douanne, Tiphaine ; Griffiths, Gillian M.</creatorcontrib><description>The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/j.ceb.2021.02.008</identifier><identifier>PMID: 33711784</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Actin ; Centrosome ; Immune synapse ; Immunodeficiencies ; Secretion</subject><ispartof>Current opinion in cell biology, 2021-08, Vol.71, p.87-94</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c8d4c7fd6bdab0f12193972ed7bf246fc7898bcacce8b2066290e6a971cee90c3</citedby><cites>FETCH-LOGICAL-c396t-c8d4c7fd6bdab0f12193972ed7bf246fc7898bcacce8b2066290e6a971cee90c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0955067421000296$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33711784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Douanne, Tiphaine</creatorcontrib><creatorcontrib>Griffiths, Gillian M.</creatorcontrib><title>Cytoskeletal control of the secretory immune synapse</title><title>Current opinion in cell biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.</description><subject>Actin</subject><subject>Centrosome</subject><subject>Immune synapse</subject><subject>Immunodeficiencies</subject><subject>Secretion</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAURYMoOo7-ADfSpZvWl7STNLiSwS8YcKPr0L6-Yse2GZOM0H9vhhldunpwOffCO4xdccg4cHm7zpDqTIDgGYgMoDxiM14qnULB4ZjNQC8WKUhVnLFz79cAIEHoU3aW54pzVRYzViynYP0n9RSqPkE7Bmf7xLZJ-KDEEzoK1k1JNwzbMQbTWG08XbCTtuo9XR7unL0_Prwtn9PV69PL8n6VYq5lSLFsClRtI-umqqHlgutcK0GNqltRyBZVqcsaK0QqawFSCg0kK604EmnAfM5u9rsbZ7-25IMZOo_U99VIduuNWAAXMvZURPkeRWe9d9SajeuGyk2Gg9nJMmsTZZmdLAPCRFmxc32Y39YDNX-NXzsRuNsDFJ_87sgZjx2NSE3nCINpbPfP_A_aCHpC</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Douanne, Tiphaine</creator><creator>Griffiths, Gillian M.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Cytoskeletal control of the secretory immune synapse</title><author>Douanne, Tiphaine ; Griffiths, Gillian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c8d4c7fd6bdab0f12193972ed7bf246fc7898bcacce8b2066290e6a971cee90c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Actin</topic><topic>Centrosome</topic><topic>Immune synapse</topic><topic>Immunodeficiencies</topic><topic>Secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Douanne, Tiphaine</creatorcontrib><creatorcontrib>Griffiths, Gillian M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Douanne, Tiphaine</au><au>Griffiths, Gillian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytoskeletal control of the secretory immune synapse</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>71</volume><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33711784</pmid><doi>10.1016/j.ceb.2021.02.008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-0674 |
| ispartof | Current opinion in cell biology, 2021-08, Vol.71, p.87-94 |
| issn | 0955-0674 1879-0410 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2501266627 |
| source | Elsevier ScienceDirect Journals |
| subjects | Actin Centrosome Immune synapse Immunodeficiencies Secretion |
| title | Cytoskeletal control of the secretory immune synapse |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T23%3A30%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytoskeletal%20control%20of%20the%20secretory%20immune%20synapse&rft.jtitle=Current%20opinion%20in%20cell%20biology&rft.au=Douanne,%20Tiphaine&rft.date=2021-08-01&rft.volume=71&rft.spage=87&rft.epage=94&rft.pages=87-94&rft.issn=0955-0674&rft.eissn=1879-0410&rft_id=info:doi/10.1016/j.ceb.2021.02.008&rft_dat=%3Cproquest_cross%3E2501266627%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2501266627&rft_id=info:pmid/33711784&rft_els_id=S0955067421000296&rfr_iscdi=true |