Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers
To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients. The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment grou...
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Veröffentlicht in: | Diabetes research and clinical practice 2021-04, Vol.174, p.108743-108743, Article 108743 |
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container_title | Diabetes research and clinical practice |
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creator | He, Shumin Liang, Caiyi Yi, Cailan Wu, Miaoli |
description | To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients.
The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment groups (n = 40 each group). The moist dressing was used in the MWD group while a micro-oxygen supply device was used in the CDO group. The combination treatment group was given both MWD and CDO. All patients were treated for 8 weeks. The wound healing, amputation rate, and inflammatory control were evaluated.
Compared with MWD and CDO groups, the combination group showed a higher wound healing rate (P |
doi_str_mv | 10.1016/j.diabres.2021.108743 |
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The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment groups (n = 40 each group). The moist dressing was used in the MWD group while a micro-oxygen supply device was used in the CDO group. The combination treatment group was given both MWD and CDO. All patients were treated for 8 weeks. The wound healing, amputation rate, and inflammatory control were evaluated.
Compared with MWD and CDO groups, the combination group showed a higher wound healing rate (P < 0.05), lower white blood cell count (P < 0.05) and lower high-sensitivity C-reactive protein level (P < 0.05). During 1-year follow-up, the amputation rate was 0% in combination group, which was significantly lower than that in other two groups (P < 0.05).
The combination of MWD and CDO was effective in promoting healing and preventing infection of DFUs, which holds a potential to be a new strategy for the treatment of this critical clinical condition.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2021.108743</identifier><identifier>PMID: 33713718</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Diabetic foot ulcer ; Moist wound dressing ; Oxygen therapy ; Wound closure</subject><ispartof>Diabetes research and clinical practice, 2021-04, Vol.174, p.108743-108743, Article 108743</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-d3e55df3b0547960d9fc55d1fdd89d73cfcb024cece15fe75e81156868a0e8823</citedby><cites>FETCH-LOGICAL-c412t-d3e55df3b0547960d9fc55d1fdd89d73cfcb024cece15fe75e81156868a0e8823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2021.108743$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33713718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Shumin</creatorcontrib><creatorcontrib>Liang, Caiyi</creatorcontrib><creatorcontrib>Yi, Cailan</creatorcontrib><creatorcontrib>Wu, Miaoli</creatorcontrib><title>Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients.
The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment groups (n = 40 each group). The moist dressing was used in the MWD group while a micro-oxygen supply device was used in the CDO group. The combination treatment group was given both MWD and CDO. All patients were treated for 8 weeks. The wound healing, amputation rate, and inflammatory control were evaluated.
Compared with MWD and CDO groups, the combination group showed a higher wound healing rate (P < 0.05), lower white blood cell count (P < 0.05) and lower high-sensitivity C-reactive protein level (P < 0.05). During 1-year follow-up, the amputation rate was 0% in combination group, which was significantly lower than that in other two groups (P < 0.05).
The combination of MWD and CDO was effective in promoting healing and preventing infection of DFUs, which holds a potential to be a new strategy for the treatment of this critical clinical condition.</description><subject>Diabetic foot ulcer</subject><subject>Moist wound dressing</subject><subject>Oxygen therapy</subject><subject>Wound closure</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkcFuEzEQhi0EomnhEUA-ckmwvetd54RQBRSpEpdytrz2uJ1o1w62lzbvwsPiTUKvSJZsjb5__hn_hLzjbMMZ7z7uNg7NkCBvBBO81lTfNi_IiqterJUQ_Uuyqpw6vi_IZc47xljXtPI1uWiantejVuTP3QMks4e5oKXgPdhCo6c2hoJhjnOmDr2fM8aw1OPT4R4CLUfRoWLTgAEcfcTyQEsyDkslzUiniLnQxzgHR12dMmO4f5bhsUPlwZQJwtFx2QaWIXyMhc6jhZTfkFfejBnenu8r8vPrl7vrm_Xtj2_frz_frm3LRVm7BqR0vhmYbPttx9zW21rg3jm1dX1jvR2YaC1Y4NJDL0FxLjvVKcNAKdFckQ-nvvsUf82Qi54wWxhHE6B-gRaScdF1rZQVlSfUpphzAq_3CSeTDpozvQSjd_ocjF6C0adgqu792WIeJnDPqn9JVODTCYC66G-EpLNFCBYcphqKdhH_Y_EXDmumPQ</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>He, Shumin</creator><creator>Liang, Caiyi</creator><creator>Yi, Cailan</creator><creator>Wu, Miaoli</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202104</creationdate><title>Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers</title><author>He, Shumin ; Liang, Caiyi ; Yi, Cailan ; Wu, Miaoli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-d3e55df3b0547960d9fc55d1fdd89d73cfcb024cece15fe75e81156868a0e8823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetic foot ulcer</topic><topic>Moist wound dressing</topic><topic>Oxygen therapy</topic><topic>Wound closure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Shumin</creatorcontrib><creatorcontrib>Liang, Caiyi</creatorcontrib><creatorcontrib>Yi, Cailan</creatorcontrib><creatorcontrib>Wu, Miaoli</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Shumin</au><au>Liang, Caiyi</au><au>Yi, Cailan</au><au>Wu, Miaoli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2021-04</date><risdate>2021</risdate><volume>174</volume><spage>108743</spage><epage>108743</epage><pages>108743-108743</pages><artnum>108743</artnum><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients.
The inpatients from May 2016 to April 2018 were enrolled and randomly divided into MWD, CDO and combination treatment groups (n = 40 each group). The moist dressing was used in the MWD group while a micro-oxygen supply device was used in the CDO group. The combination treatment group was given both MWD and CDO. All patients were treated for 8 weeks. The wound healing, amputation rate, and inflammatory control were evaluated.
Compared with MWD and CDO groups, the combination group showed a higher wound healing rate (P < 0.05), lower white blood cell count (P < 0.05) and lower high-sensitivity C-reactive protein level (P < 0.05). During 1-year follow-up, the amputation rate was 0% in combination group, which was significantly lower than that in other two groups (P < 0.05).
The combination of MWD and CDO was effective in promoting healing and preventing infection of DFUs, which holds a potential to be a new strategy for the treatment of this critical clinical condition.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33713718</pmid><doi>10.1016/j.diabres.2021.108743</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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language | eng |
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source | Access via ScienceDirect (Elsevier) |
subjects | Diabetic foot ulcer Moist wound dressing Oxygen therapy Wound closure |
title | Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers |
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