Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia

Summary B‐cell acute lymphoblastic leukaemia (B‐ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia‐supportive niche. To elucidate the contribution of immune cells to the leukaemic microenvironment, we investigated the involvement of monocyte/macrophage compartments, as wel...

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Veröffentlicht in:	British journal of haematology 2021-06, Vol.193 (6), p.1157-1171
Hauptverfasser:	Dander, Erica, Fallati, Alessandra, Gulić, Tamara, Pagni, Fabio, Gaspari, Stefania, Silvestri, Daniela, Cricrì, Giulia, Bedini, Gloria, Portale, Federica, Buracchi, Chiara, Starace, Rita, Pasqualini, Fabio, D'Angiò, Mariella, Brizzolara, Lisa, Maglia, Oscar, Mantovani, Alberto, Garlanda, Cecilia, Valsecchi, Maria Grazia, Locatelli, Franco, Biondi, Andrea, Bottazzi, Barbara, Allavena, Paola, D'Amico, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukaemia Acute lymphoblastic leukemia Bone marrow bone marrow microenvironment CD14 antigen CD16 antigen CD163 antigen Cell activation Chemokines Chemotherapy Complement activation Complement component C5a CX3CR1 protein Hematology Immunohistochemistry Inflammation Leukemia Macrophages Mesenchymal stem cells mesenchymal stromal cells Mesenchyme Microenvironments Monocyte chemoattractant protein 1 Monocytes Peripheral blood Stromal cells Tumor microenvironment Tumors
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