Dose-related morphological changes in the epididymal region of sexually active adult male Japanese quail treated with di-n-butyl phthalate (DBP) commencing during the pre-pubertal stage
•Di-n-butyl phthalate (DBP) induces dose-dependent toxicity in quail’s epididymis.•The proximal efferent ductule is more sensitive to the effects of the DBP.•Oligospermia was observed in the lumen of epididymal duct of adult Japanese quails.•Pre-pubertal exposure to DBP could cause infertility in th...
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| Veröffentlicht in: | Animal reproduction science 2021-04, Vol.227, p.106733-106733, Article 106733 |
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| creator | Ibrahim, Mohammed I.A. Williams, June Botha, Christo J. |
| description | •Di-n-butyl phthalate (DBP) induces dose-dependent toxicity in quail’s epididymis.•The proximal efferent ductule is more sensitive to the effects of the DBP.•Oligospermia was observed in the lumen of epididymal duct of adult Japanese quails.•Pre-pubertal exposure to DBP could cause infertility in the adult Japanese quails.
Di-n-butyl phthalate (DBP) is widely used as a plasticizer in personal care and medical products and is known to induce toxicity in the male reproductive organs in both mammals and birds. In this study, there was investigation of the effects of DBP on the epithelium of the rete testis, proximal, and distal efferent ductules and epididymal duct of adult Japanese quail (Coturnix japonica) following treatment with varying doses during the pre-pubertal and peri-pubertal periods. Pre-pubertal quail (n = 25) 4 weeks post-hatching were dosed orally with 10, 50, 200 and 400 mg DBP/kg/d, for 30 days and control birds were administered corn-oil only (n = 5 per group). Histo-metrically, there was lesser (P |
| doi_str_mv | 10.1016/j.anireprosci.2021.106733 |
| format | Article |
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Di-n-butyl phthalate (DBP) is widely used as a plasticizer in personal care and medical products and is known to induce toxicity in the male reproductive organs in both mammals and birds. In this study, there was investigation of the effects of DBP on the epithelium of the rete testis, proximal, and distal efferent ductules and epididymal duct of adult Japanese quail (Coturnix japonica) following treatment with varying doses during the pre-pubertal and peri-pubertal periods. Pre-pubertal quail (n = 25) 4 weeks post-hatching were dosed orally with 10, 50, 200 and 400 mg DBP/kg/d, for 30 days and control birds were administered corn-oil only (n = 5 per group). Histo-metrically, there was lesser (P < 0.001) epithelial heights of the rete testis and efferent ductules in all quail DBP-treated groups, but not in the epididymal duct epithelium. There were no morphological change effects as a result of DBP treatments in the rete testis epithelium, while there were epithelial cytoplasmic vacuoles detected in the distal efferent ductule and epididymal duct of birds treated with 50, 200 and 400 mg DPB/kg/d. There were several lesions, including degenerative changes, cytoplasmic vacuoles, apoptosis and autophagy in the epithelium of the proximal efferent ductule in quail treated with 200 and 400 mg DBP/kg/d. Overall, the results indicate that treatment with DBP during the pre-pubertal period induced dose-dependent histometric and morphological changes in the epithelium of the epididymal region. It is concluded that the proximal efferent ductule was a highly sensitive component of the epididymal tissues of Japanese quail following treatment with DBP during the pre-pubertal period.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/j.anireprosci.2021.106733</identifier><identifier>PMID: 33713912</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Di-n-butyl phthalate ; Efferent ductules ; Epididymal duct ; Japanese quail ; Morphology ; Rete testis</subject><ispartof>Animal reproduction science, 2021-04, Vol.227, p.106733-106733, Article 106733</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-33d880321f7fb22c3caddbc4b148c33a78629a858f69c3e52da8b67cd56e411e3</citedby><cites>FETCH-LOGICAL-c377t-33d880321f7fb22c3caddbc4b148c33a78629a858f69c3e52da8b67cd56e411e3</cites><orcidid>0000-0003-1535-9270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anireprosci.2021.106733$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33713912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibrahim, Mohammed I.A.</creatorcontrib><creatorcontrib>Williams, June</creatorcontrib><creatorcontrib>Botha, Christo J.</creatorcontrib><title>Dose-related morphological changes in the epididymal region of sexually active adult male Japanese quail treated with di-n-butyl phthalate (DBP) commencing during the pre-pubertal stage</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>•Di-n-butyl phthalate (DBP) induces dose-dependent toxicity in quail’s epididymis.•The proximal efferent ductule is more sensitive to the effects of the DBP.•Oligospermia was observed in the lumen of epididymal duct of adult Japanese quails.•Pre-pubertal exposure to DBP could cause infertility in the adult Japanese quails.
Di-n-butyl phthalate (DBP) is widely used as a plasticizer in personal care and medical products and is known to induce toxicity in the male reproductive organs in both mammals and birds. In this study, there was investigation of the effects of DBP on the epithelium of the rete testis, proximal, and distal efferent ductules and epididymal duct of adult Japanese quail (Coturnix japonica) following treatment with varying doses during the pre-pubertal and peri-pubertal periods. Pre-pubertal quail (n = 25) 4 weeks post-hatching were dosed orally with 10, 50, 200 and 400 mg DBP/kg/d, for 30 days and control birds were administered corn-oil only (n = 5 per group). Histo-metrically, there was lesser (P < 0.001) epithelial heights of the rete testis and efferent ductules in all quail DBP-treated groups, but not in the epididymal duct epithelium. There were no morphological change effects as a result of DBP treatments in the rete testis epithelium, while there were epithelial cytoplasmic vacuoles detected in the distal efferent ductule and epididymal duct of birds treated with 50, 200 and 400 mg DPB/kg/d. There were several lesions, including degenerative changes, cytoplasmic vacuoles, apoptosis and autophagy in the epithelium of the proximal efferent ductule in quail treated with 200 and 400 mg DBP/kg/d. Overall, the results indicate that treatment with DBP during the pre-pubertal period induced dose-dependent histometric and morphological changes in the epithelium of the epididymal region. It is concluded that the proximal efferent ductule was a highly sensitive component of the epididymal tissues of Japanese quail following treatment with DBP during the pre-pubertal period.</description><subject>Di-n-butyl phthalate</subject><subject>Efferent ductules</subject><subject>Epididymal duct</subject><subject>Japanese quail</subject><subject>Morphology</subject><subject>Rete testis</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhi1ERZfCX0DmVg7Z-mMTJ0fY8lVVggOcLceeJF45cWo7hf1p_DsctqAeOY1kvzOPZh6EXlOypYRWV4etmmyAOfio7ZYRRvN7JTh_gja0FrxgjLOnaEO4qIsdZ-QcPY_xQAgRVdU8Q-ecC8obyjbo17WPUARwKoHBow_z4J3vrVYO60FNPURsJ5wGwDBbY81xzD8Beusn7Dsc4eeinDtipZO9B6zM4hLOGcA3alYTRMB3i7IOpwB_GD9sGrCxxVS0Szo6PA9pUCseX16_-_oGaz-OMGk79dgsYS0rfA5QzEsLIWV8TKqHF-isUy7Cy4d6gb5_eP9t_6m4_fLx8_7tbaG5EKng3NQ14Yx2omsZ01wrY1q9a-mu1pwrUVesUXVZd1WjOZTMqLqthDZlBTtKgV-gy9PcfO67BWKSo40anMvL-SVKVhLKSkErnqPNKaqzmRigk3OwowpHSYlczcmDfGROrubkyVzuffWAWdoRzL_Ov6pyYH8KQF723kKQeUQ-FJg8UCdpvP0PzG_Ky7RL</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Ibrahim, Mohammed I.A.</creator><creator>Williams, June</creator><creator>Botha, Christo J.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1535-9270</orcidid></search><sort><creationdate>202104</creationdate><title>Dose-related morphological changes in the epididymal region of sexually active adult male Japanese quail treated with di-n-butyl phthalate (DBP) commencing during the pre-pubertal stage</title><author>Ibrahim, Mohammed I.A. ; Williams, June ; Botha, Christo J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-33d880321f7fb22c3caddbc4b148c33a78629a858f69c3e52da8b67cd56e411e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Di-n-butyl phthalate</topic><topic>Efferent ductules</topic><topic>Epididymal duct</topic><topic>Japanese quail</topic><topic>Morphology</topic><topic>Rete testis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibrahim, Mohammed I.A.</creatorcontrib><creatorcontrib>Williams, June</creatorcontrib><creatorcontrib>Botha, Christo J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibrahim, Mohammed I.A.</au><au>Williams, June</au><au>Botha, Christo J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-related morphological changes in the epididymal region of sexually active adult male Japanese quail treated with di-n-butyl phthalate (DBP) commencing during the pre-pubertal stage</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>2021-04</date><risdate>2021</risdate><volume>227</volume><spage>106733</spage><epage>106733</epage><pages>106733-106733</pages><artnum>106733</artnum><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>•Di-n-butyl phthalate (DBP) induces dose-dependent toxicity in quail’s epididymis.•The proximal efferent ductule is more sensitive to the effects of the DBP.•Oligospermia was observed in the lumen of epididymal duct of adult Japanese quails.•Pre-pubertal exposure to DBP could cause infertility in the adult Japanese quails.
Di-n-butyl phthalate (DBP) is widely used as a plasticizer in personal care and medical products and is known to induce toxicity in the male reproductive organs in both mammals and birds. In this study, there was investigation of the effects of DBP on the epithelium of the rete testis, proximal, and distal efferent ductules and epididymal duct of adult Japanese quail (Coturnix japonica) following treatment with varying doses during the pre-pubertal and peri-pubertal periods. Pre-pubertal quail (n = 25) 4 weeks post-hatching were dosed orally with 10, 50, 200 and 400 mg DBP/kg/d, for 30 days and control birds were administered corn-oil only (n = 5 per group). Histo-metrically, there was lesser (P < 0.001) epithelial heights of the rete testis and efferent ductules in all quail DBP-treated groups, but not in the epididymal duct epithelium. There were no morphological change effects as a result of DBP treatments in the rete testis epithelium, while there were epithelial cytoplasmic vacuoles detected in the distal efferent ductule and epididymal duct of birds treated with 50, 200 and 400 mg DPB/kg/d. There were several lesions, including degenerative changes, cytoplasmic vacuoles, apoptosis and autophagy in the epithelium of the proximal efferent ductule in quail treated with 200 and 400 mg DBP/kg/d. Overall, the results indicate that treatment with DBP during the pre-pubertal period induced dose-dependent histometric and morphological changes in the epithelium of the epididymal region. It is concluded that the proximal efferent ductule was a highly sensitive component of the epididymal tissues of Japanese quail following treatment with DBP during the pre-pubertal period.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33713912</pmid><doi>10.1016/j.anireprosci.2021.106733</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1535-9270</orcidid></addata></record> |
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| subjects | Di-n-butyl phthalate Efferent ductules Epididymal duct Japanese quail Morphology Rete testis |
| title | Dose-related morphological changes in the epididymal region of sexually active adult male Japanese quail treated with di-n-butyl phthalate (DBP) commencing during the pre-pubertal stage |
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