Aging and β3-adrenergic stimulation alter mitochondrial lipidome of adipose tissue

Mitochondrial abundance and thermogenic capacity are two imperative components that distinguish brown, beige and white adipose tissues. Most importantly, the lipid composition is vital for maintaining the quantity, quality and function of mitochondria. Therefore, we employed quantitative lipidomics...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2021-07, Vol.1866 (7), p.158922, Article 158922
Hauptverfasser:	Rajakumari, Sona, Srivastava, Simran
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl chain desaturation Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue, Beige - drug effects Adipose Tissue, Beige - metabolism Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Adrenergic beta-3 Receptor Agonists - pharmacology Aging Aging - metabolism Animals Dioxoles - pharmacology Lipid Metabolism - drug effects Lipidomics - methods Male Mice Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Mitochondrial lipidome Phosphatidylcholines - metabolism Phosphatidylethanolamines - metabolism Receptors, Adrenergic, beta-3 - metabolism Thermogenesis Thermogenesis - drug effects β3-adrenergic stimulation
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