Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress

Acetyl-L-carnitine has been shown to exert neuroprotection against neurodegenerative diseases. The present study was performed to evaluate neuroprotection effects of acetyl-L-carnitine against lipopolysaccharide (LPS) -induced neuroinflammation and clarify possible mechanisms. A single dose (500 µg/...

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Veröffentlicht in:	Metabolic brain disease 2021-08, Vol.36 (6), p.1391-1401
Hauptverfasser:	Jamali-Raeufy, Nida, Alizadeh, Fahimeh, Mehrabi, Zhila, Mehrabi, Soraya, Goudarzi, Mina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-L-carnitine Acetylcarnitine - pharmacology Animals Anti-Inflammatory Agents - pharmacology Autophagy Autophagy - drug effects Beclin-1 - antagonists & inhibitors Biochemistry Biomedical and Life Sciences Biomedicine Carnitine Enzyme-linked immunosorbent assay Inflammation Injections, Intraperitoneal Lipopolysaccharides Male Markers Metabolic Diseases Microtubule-Associated Proteins - antagonists & inhibitors Neurodegenerative diseases Neuroinflammatory Diseases - chemically induced Neuroinflammatory Diseases - prevention & control Neuroinflammatory Diseases - psychology Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosciences NF-kappa B - drug effects NF-κB protein Object recognition Oncology Original Article Oxidation Oxidative stress Oxidative Stress - drug effects Pattern recognition Phagocytosis Psychomotor Performance - drug effects Rats Rats, Wistar TLR4 protein Toll-Like Receptor 4 - drug effects Toll-like receptors
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