Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients

High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive traj...

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Veröffentlicht in:CNS spectrums 2022-10, Vol.27 (5), p.598-603
Hauptverfasser: Chang, Hui Hua, Tseng, Huai-Hsuan, Chang, Wei Hung, Huang, Kuan-Chung, Lu, Tsung-Hua, Yang, Yen Kuang, Chen, Po See
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container_end_page 603
container_issue 5
container_start_page 598
container_title CNS spectrums
container_volume 27
creator Chang, Hui Hua
Tseng, Huai-Hsuan
Chang, Wei Hung
Huang, Kuan-Chung
Lu, Tsung-Hua
Yang, Yen Kuang
Chen, Po See
description High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive trajectory in euthymic BD. We aimed to examine differences in insulin sensitivity and executive function between BD patients and controls. Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors. The results indicated that the HOMA-IR (  = .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (  
doi_str_mv 10.1017/S1092852921000158
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Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive trajectory in euthymic BD. We aimed to examine differences in insulin sensitivity and executive function between BD patients and controls. Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors. The results indicated that the HOMA-IR (  = .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (  &lt; .05). Moreover, the interaction effect between BD diagnosis and HOMA-IR value on the WCST-preservation errors was significant (  = .01), and analyses showed that the cognitive abilities were worse in the BD patients with a higher IR than in the others groups. Insulin sensitivity is associated with the neurocognitive performance in euthymic BD patients. 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subjects Antipsychotics
Bipolar disorder
Bipolar Disorder - complications
Bipolar Disorder - diagnosis
Bipolar Disorder - drug therapy
Body mass index
Cerebrovascular disease
Chronic illnesses
Cognition
Cognitive ability
Cyclothymic Disorder
Diabetes
Disease prevention
Electroconvulsive therapy
Emotional disorders
Executive Function
Glucose
Humans
Hyperglycemia
Insulin Resistance
Laboratories
Metabolic syndrome
Mood disorders
Neurodegeneration
Neuropsychological Tests
Original Research
Patients
Psychopathology
Psychotropic drugs
title Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients
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