Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients
High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive traj...
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Veröffentlicht in: | CNS spectrums 2022-10, Vol.27 (5), p.598-603 |
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description | High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive trajectory in euthymic BD. We aimed to examine differences in insulin sensitivity and executive function between BD patients and controls.
Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors.
The results indicated that the HOMA-IR (
= .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (
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doi_str_mv | 10.1017/S1092852921000158 |
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Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors.
The results indicated that the HOMA-IR (
= .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (
< .05). Moreover, the interaction effect between BD diagnosis and HOMA-IR value on the WCST-preservation errors was significant (
= .01), and
analyses showed that the cognitive abilities were worse in the BD patients with a higher IR than in the others groups.
Insulin sensitivity is associated with the neurocognitive performance in euthymic BD patients. Although the underlying mechanisms remain unclear, interventions to improve insulin sensitivity could potentially improve the functional outcome of BD.</description><identifier>ISSN: 1092-8529</identifier><identifier>EISSN: 2165-6509</identifier><identifier>DOI: 10.1017/S1092852921000158</identifier><identifier>PMID: 33691827</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Antipsychotics ; Bipolar disorder ; Bipolar Disorder - complications ; Bipolar Disorder - diagnosis ; Bipolar Disorder - drug therapy ; Body mass index ; Cerebrovascular disease ; Chronic illnesses ; Cognition ; Cognitive ability ; Cyclothymic Disorder ; Diabetes ; Disease prevention ; Electroconvulsive therapy ; Emotional disorders ; Executive Function ; Glucose ; Humans ; Hyperglycemia ; Insulin Resistance ; Laboratories ; Metabolic syndrome ; Mood disorders ; Neurodegeneration ; Neuropsychological Tests ; Original Research ; Patients ; Psychopathology ; Psychotropic drugs</subject><ispartof>CNS spectrums, 2022-10, Vol.27 (5), p.598-603</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press</rights><rights>The Author(s), 2021. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-52bb60553aeca82bef393bb662deaabe68f2dd24fef8ad1484a95198c43621c33</citedby><cites>FETCH-LOGICAL-c416t-52bb60553aeca82bef393bb662deaabe68f2dd24fef8ad1484a95198c43621c33</cites><orcidid>0000-0003-4963-578X ; 0000-0001-9355-9636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1092852921000158/type/journal_article$$EHTML$$P50$$Gcambridge$$Hfree_for_read</linktohtml><link.rule.ids>164,314,777,781,27905,27906,55609</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33691827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Hui Hua</creatorcontrib><creatorcontrib>Tseng, Huai-Hsuan</creatorcontrib><creatorcontrib>Chang, Wei Hung</creatorcontrib><creatorcontrib>Huang, Kuan-Chung</creatorcontrib><creatorcontrib>Lu, Tsung-Hua</creatorcontrib><creatorcontrib>Yang, Yen Kuang</creatorcontrib><creatorcontrib>Chen, Po See</creatorcontrib><title>Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients</title><title>CNS spectrums</title><addtitle>CNS Spectr</addtitle><description>High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive trajectory in euthymic BD. We aimed to examine differences in insulin sensitivity and executive function between BD patients and controls.
Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors.
The results indicated that the HOMA-IR (
= .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (
< .05). Moreover, the interaction effect between BD diagnosis and HOMA-IR value on the WCST-preservation errors was significant (
= .01), and
analyses showed that the cognitive abilities were worse in the BD patients with a higher IR than in the others groups.
Insulin sensitivity is associated with the neurocognitive performance in euthymic BD patients. Although the underlying mechanisms remain unclear, interventions to improve insulin sensitivity could potentially improve the functional outcome of BD.</description><subject>Antipsychotics</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - complications</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Body mass index</subject><subject>Cerebrovascular disease</subject><subject>Chronic illnesses</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cyclothymic Disorder</subject><subject>Diabetes</subject><subject>Disease prevention</subject><subject>Electroconvulsive therapy</subject><subject>Emotional disorders</subject><subject>Executive Function</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin Resistance</subject><subject>Laboratories</subject><subject>Metabolic syndrome</subject><subject>Mood disorders</subject><subject>Neurodegeneration</subject><subject>Neuropsychological Tests</subject><subject>Original Research</subject><subject>Patients</subject><subject>Psychopathology</subject><subject>Psychotropic drugs</subject><issn>1092-8529</issn><issn>2165-6509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1LxDAQhoMo7rr6A7xIwIuXaj6aND3K4hcICuq5pMl0N0ub1qQV9t_bZVcFxdPAO8_7zjCD0Ckll5TQ7OqFkpwpwXJGCSFUqD00ZVSKRAqS76Pppp1s-hN0FOOKkJRnih-iCecyp4plU1Q-Q3DdEoKusfNxqJ3HEXx0vftw_Rp3AawzvfMLbNqF38iAq8GPUutHB4ahX64bZ3DpurbWAVsX22Ah4E73Dnwfj9FBpesIJ7s6Q2-3N6_z--Tx6e5hfv2YmJTKPhGsLCURgmswWrESKp7zUZLMgtYlSFUxa1laQaW0palKdS5orkzKJaOG8xm62OZ2oX0fIPZF46KButYe2iEWTBDCFUtzMqLnv9BVOwQ_blewjCnCUimzkaJbyoQ2xgBV0QXX6LAuKCk2Dyj-PGD0nO2Sh7IB--34uvgI8F2obsrg7AJ-Zv8f-wkEAZGy</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Chang, Hui Hua</creator><creator>Tseng, Huai-Hsuan</creator><creator>Chang, Wei Hung</creator><creator>Huang, Kuan-Chung</creator><creator>Lu, Tsung-Hua</creator><creator>Yang, Yen Kuang</creator><creator>Chen, Po See</creator><general>Cambridge University Press</general><scope>IKXGN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4963-578X</orcidid><orcidid>https://orcid.org/0000-0001-9355-9636</orcidid></search><sort><creationdate>20221001</creationdate><title>Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients</title><author>Chang, Hui Hua ; Tseng, Huai-Hsuan ; Chang, Wei Hung ; Huang, Kuan-Chung ; Lu, Tsung-Hua ; Yang, Yen Kuang ; Chen, Po See</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-52bb60553aeca82bef393bb662deaabe68f2dd24fef8ad1484a95198c43621c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antipsychotics</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - complications</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Body mass index</topic><topic>Cerebrovascular disease</topic><topic>Chronic illnesses</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cyclothymic Disorder</topic><topic>Diabetes</topic><topic>Disease prevention</topic><topic>Electroconvulsive therapy</topic><topic>Emotional disorders</topic><topic>Executive Function</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin Resistance</topic><topic>Laboratories</topic><topic>Metabolic syndrome</topic><topic>Mood disorders</topic><topic>Neurodegeneration</topic><topic>Neuropsychological Tests</topic><topic>Original Research</topic><topic>Patients</topic><topic>Psychopathology</topic><topic>Psychotropic drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Hui Hua</creatorcontrib><creatorcontrib>Tseng, Huai-Hsuan</creatorcontrib><creatorcontrib>Chang, Wei Hung</creatorcontrib><creatorcontrib>Huang, Kuan-Chung</creatorcontrib><creatorcontrib>Lu, Tsung-Hua</creatorcontrib><creatorcontrib>Yang, Yen Kuang</creatorcontrib><creatorcontrib>Chen, Po See</creatorcontrib><collection>Cambridge Journals Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>CNS spectrums</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Hui Hua</au><au>Tseng, Huai-Hsuan</au><au>Chang, Wei Hung</au><au>Huang, Kuan-Chung</au><au>Lu, Tsung-Hua</au><au>Yang, Yen Kuang</au><au>Chen, Po See</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients</atitle><jtitle>CNS spectrums</jtitle><addtitle>CNS Spectr</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>27</volume><issue>5</issue><spage>598</spage><epage>603</epage><pages>598-603</pages><issn>1092-8529</issn><eissn>2165-6509</eissn><abstract>High prevalence of insulin resistance (IR) has been reported in bipolar disorder (BD) patients. Importantly, impaired insulin sensitivity could modulate the course and treatment outcome in BD. Here, we hypothesized that insulin sensitivity could be potentially associated with the neurocognitive trajectory in euthymic BD. We aimed to examine differences in insulin sensitivity and executive function between BD patients and controls.
Sixty-two patients with BD receiving mood stabilizer treatment and 62 controls, matching age, sex, and body mass index, were recruited in this study. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The Wisconsin card-sorting test (WCST) was applied to test participants' ability to shift cognitive set. Group differences were measured and multivariate regression analysis was performed to examine relationships among factors.
The results indicated that the HOMA-IR (
= .048) value in the patients with BD were significantly higher than those in controls. With regards to executive function, the BD patients performed significantly poorer than the control subjects (
< .05). Moreover, the interaction effect between BD diagnosis and HOMA-IR value on the WCST-preservation errors was significant (
= .01), and
analyses showed that the cognitive abilities were worse in the BD patients with a higher IR than in the others groups.
Insulin sensitivity is associated with the neurocognitive performance in euthymic BD patients. Although the underlying mechanisms remain unclear, interventions to improve insulin sensitivity could potentially improve the functional outcome of BD.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>33691827</pmid><doi>10.1017/S1092852921000158</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4963-578X</orcidid><orcidid>https://orcid.org/0000-0001-9355-9636</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antipsychotics Bipolar disorder Bipolar Disorder - complications Bipolar Disorder - diagnosis Bipolar Disorder - drug therapy Body mass index Cerebrovascular disease Chronic illnesses Cognition Cognitive ability Cyclothymic Disorder Diabetes Disease prevention Electroconvulsive therapy Emotional disorders Executive Function Glucose Humans Hyperglycemia Insulin Resistance Laboratories Metabolic syndrome Mood disorders Neurodegeneration Neuropsychological Tests Original Research Patients Psychopathology Psychotropic drugs |
title | Peripheral insulin sensitivity predicting cognitive function in euthymic bipolar disorder patients |
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