Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas

WHO 2016 classified glioblastomas into IDH-mutant and IDH-wildtype with the former having a better prognosis but there was no study on IDH-mutant primary glioblastomas only, as previous series included secondary glioblastomas. We recruited a series of 67 IDH-mutant primary glioblastomas/astrocytoma...

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Veröffentlicht in:	Modern pathology 2021-07, Vol.34 (7), p.1245-1260
Hauptverfasser:	Wong, Queenie Hoi-Wing, Li, Kay Ka-Wai, Wang, Wei-Wei, Malta, Tathiane M., Noushmehr, Houtan, Grabovska, Yura, Jones, Chris, Chan, Aden Ka-Yin, Kwan, Johnny Sheung-Him, Huang, Queenie Jun-Qi, Wong, Gabriel Chun-Hei, Li, Wen-Cai, Liu, Xian-Zhi, Chen, Hong, Chan, Danny Tat-Ming, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 631/67/1922 631/67/69 Adult Astrocytoma Astrocytoma - genetics Astrocytoma - mortality Astrocytoma - pathology Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Chromatin Deoxyribonucleic acid DNA DNA fingerprinting DNA methylation DNA Mutational Analysis DNA sequencing Female Gene deletion Glioblastoma - genetics Glioblastoma - mortality Glioblastoma - pathology Humans Isocitrate Dehydrogenase - genetics Laboratory Medicine Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mismatch repair Mutants Mutation p53 Protein Pathology Prognosis Telomeres
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